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公开(公告)号：US20240201191A1
公开(公告)日：2024-06-20
申请号：US18285205
申请日：2022-03-30
发明人： Samir HANASH , Hiroyuki KATAYAMA
IPC分类号： G01N33/574 , G01N33/68
CPC分类号： G01N33/57484 , G01N33/6848 , G01N2333/988 , G01N2440/18
摘要： Provided herein are methods of detecting cancer, diagnosing a subject with cancer, treating a subject with cancer, and reducing the risk of or preventing cancer in a subject. The methods are based in part on the discovery of dysregulated protein citrullination by protein arginine deaminase enzymes in cancer. Also provided are citrullinated peptides and kits that are expressed at a higher level in cancer cells than in corresponding normal cells. Kits and systems relating to these methods are also provided.
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2.发明授权公开(公告)号：US12007395B2
公开(公告)日：2024-06-11
申请号：US16433106
申请日：2019-06-06
CPC分类号： G01N33/6848 , G01N33/5306 , G01N33/6842 , H01J49/0027 , H01J49/0077 , G01N2440/18 , G01N2800/28
摘要： The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injury or neurodegeneration. In one embodiment, a method for diagnosing brain injury in a patient comprises the steps of (a) obtaining a sample from the patient; (b) determining the ratio of citrullinated to unmodified arginine residues at one or more arginine residues of one or more brain injury biomarker proteins; and (c) correlating the ratio to a patient having brain injury or to a patient not having brain injury, thereby providing the diagnosis.
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3.发明授权公开(公告)号：US11913950B2
公开(公告)日：2024-02-27
申请号：US16195582
申请日：2018-11-19
发明人： Anthony Marotta
IPC分类号： G01N33/53 , G01N33/564 , G01N33/68 , C07K14/47 , G01N33/543
CPC分类号： G01N33/564 , C07K14/47 , C07K14/4713 , G01N33/54306 , G01N33/6893 , G01N2440/18 , G01N2800/105
摘要： The present invention provides citrullinated 14-3-3η peptides and antibodies thereto and methods of using same to evaluate arthritic conditions such as rheumatoid arthritis.
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公开(公告)号：US20150148259A1
公开(公告)日：2015-05-28
申请号：US14405467
申请日：2013-06-04
IPC分类号： G01N33/68 , C07D311/90 , G01N33/92 , C07D495/04 , C07C45/61 , G01N33/58 , C07C49/86 , C07D311/86
CPC分类号： G01N33/581 , C07B59/00 , C07B2200/05 , C07C45/61 , C07C49/86 , C07C247/04 , C07D311/86 , C07D311/90 , C07D493/10 , C07D495/04 , C12Q1/34 , G01N33/532 , G01N33/582 , G01N33/583 , G01N33/68 , G01N33/6803 , G01N33/6893 , G01N33/92 , G01N2333/775 , G01N2333/978 , G01N2440/18 , G01N2458/15 , G01N2500/00 , G01N2570/00
摘要： Novel phenyl-glyoxal based anti-citrulline probes and methods of synthesis are provided. Methods of use, such as, the development of methods for monitoring substrate citrullination over time; for identifying citrullinated proteins from cells are described.
摘要翻译： 提供了新的苯基乙二醛基抗瓜氨酸探针和合成方法。 使用方法，例如开发用于随时间监测底物瓜氨酸化的方法; 用于鉴定来自细胞的瓜氨酸化蛋白质。
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5.发明申请CITRULLINATED PROTEINS: A POST-TRANSLATED MODIFICATION OF MYOCARDIAL PROTEINS AS MARKER OF PHYSIOLOGICAL AND PATHOLOGICAL DISEASE 审中-公开CITRULLINATED蛋白质：作为生理和病理疾病标记的肌肉蛋白质的翻译后修饰公开(公告)号：US20140308676A1
公开(公告)日：2014-10-16
申请号：US13885146
申请日：2011-11-14
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , C12Q1/34 , G01N33/564 , G01N33/6812 , G01N33/6848 , G01N2440/18 , G01N2800/32 , G01N2800/50
摘要： Disclosed herein are methods for diagnosing cardiovascular disease. The methods comprise detection of citrullinated proteins.
摘要翻译： 本文公开了用于诊断心血管疾病的方法。 该方法包括检测瓜氨酸化蛋白质。
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公开(公告)号：US20230213527A1
公开(公告)日：2023-07-06
申请号：US18145815
申请日：2022-12-22
发明人： Brian Reed , Manjula Pandey , David Kamber , Kenneth Skinner
IPC分类号： G01N33/68
CPC分类号： G01N33/6818 , G01N33/6893 , G01N2440/12 , G01N2440/18 , G01N2440/10 , G01N2440/14 , G01N2800/102 , G01N2800/2821 , G01N2800/32
摘要： Aspects of the application relate to methods and systems for obtaining information regarding multiple amino acids in a polypeptide based on binding interactions between the polypeptide and one or more amino acid recognizers. Kinetic signature information may be obtained from a series of signal pulses indicative of a series of binding events between one or more amino acid recognizers and an amino acid of a polypeptide (e.g., a terminal amino acid, an internal amino acid). The kinetic signature information (e.g., pulse duration, interpulse duration, recognition segment (RS) duration, intersegment duration) may be used to determine one or more chemical characteristics (e.g., identity, modification) of multiple amino acids of the polypeptide.
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公开(公告)号：US20180346537A1
公开(公告)日：2018-12-06
申请号：US16007944
申请日：2018-06-13
申请人： SCANCELL LIMITED
IPC分类号： C07K14/47 , G01N33/574 , C07K7/06 , C07K7/08 , A61K39/00
CPC分类号： C07K14/4748 , A61K39/0011 , C07K7/06 , C07K7/08 , G01N33/57419 , G01N33/57449 , G01N33/57496 , G01N2333/47 , G01N2333/978 , G01N2440/18 , G01N2800/52
摘要： Anti-tumour immune responses to modified self-epitopes. The present invention relates to the use of tumour-associated epitopes in medicine and in particular in the treatment of cancer. The epitopes stimulate an immune reaction against the tumour and have a modification selected from deimination of arginine to citrulline, nitration of tyrosine, oxidation of tryptophan and deamination of glutamine or asparagine. The invention also relates to nucleic acids comprising sequences that encode such epitopes for use in the treatment of cancer.
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公开(公告)号：US09921225B2
公开(公告)日：2018-03-20
申请号：US15160079
申请日：2016-05-20
IPC分类号： C07C45/00 , C07C49/00 , C07D311/00 , C07B59/00 , G01N33/58 , C12Q1/34 , G01N33/532 , G01N33/68 , C07C49/86 , C07C247/04 , C07C45/61 , C07D311/86 , C07D311/90 , C07D495/04 , G01N33/92 , C07D493/10
CPC分类号： G01N33/581 , C07B59/00 , C07B2200/05 , C07C45/61 , C07C49/86 , C07C247/04 , C07D311/86 , C07D311/90 , C07D493/10 , C07D495/04 , C12Q1/34 , G01N33/532 , G01N33/582 , G01N33/583 , G01N33/68 , G01N33/6803 , G01N33/6893 , G01N33/92 , G01N2333/775 , G01N2333/978 , G01N2440/18 , G01N2458/15 , G01N2500/00 , G01N2570/00
摘要： Novel phenyl-glyoxal based anti-citrulline probes and methods of synthesis are provided. Methods of use, such as, the development of methods for monitoring substrate citrullination over time; for identifying citrullinated proteins from cells are described.
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9.发明授权公开(公告)号：US09709573B2
公开(公告)日：2017-07-18
申请号：US14384848
申请日：2013-03-13
IPC分类号： C12Q1/00 , G01N33/53 , G01N33/542 , G01N33/68 , H01J49/00
CPC分类号： G01N33/6848 , G01N33/5306 , G01N33/6842 , G01N2440/18 , G01N2800/28 , H01J49/0027 , H01J49/0077
摘要： The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injury or neurodegeneration. In one embodiment, a method for diagnosing brain injury in a patient comprises the steps of (a) obtaining a sample from the patient; (b) determining the ratio of citrullinated to unmodified arginine residues at one or more arginine residues of one or more brain injury biomarker proteins; and (c) correlating the ratio to a patient having brain injury or to a patient not having brain injury, thereby providing the diagnosis.
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公开(公告)号：US20140057829A1
公开(公告)日：2014-02-27
申请号：US13981032
申请日：2012-02-01
申请人： Hasan B. Alam , Yongqing Li
发明人： Hasan B. Alam , Yongqing Li
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/6875 , G01N2440/18 , G01N2800/26 , G01N2800/32 , G01N2800/52 , G01N2800/56
摘要： Methods of diagnosing sepsis, severe sepsis, or septic shock and predicting prognosis in subjects with septic shock, based on levels of citrullinated histone H3 (Cit H3) in the subject, e.g., in a sample comprising serum (e.g., whole blood, serum, or plasma), cerebrospinal fluid, urine, saliva, or peritoneal fluid from the subject.
摘要翻译： 基于受试者的瓜氨酸化组蛋白H3（Cit H3）的水平，例如在含有血清（例如全血，血清，血清，血清，血清， 或血浆），脑脊液，尿液，唾液或腹膜液。
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