公开(公告)号：US20170290841A1

公开(公告)日：2017-10-12

申请号：US15514259

申请日：2015-09-25

Applicant: KOWA COMPANY, LTD.

Inventor： Shin SUGIMOTO

IPC: A61K31/551 ,  A61K33/42 ,  A61K9/00 ,  A61K31/435

CPC classification number: A61K31/551 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/435 ,  A61K33/42 ,  A61K47/18

Abstract: An aqueous composition having an excellent antiseptic effect is provided. An aqueous composition comprising a compound represented by Formula (1), wherein X represents a halogen atom, or a salt thereof, or a solvate of the compound or the salt thereof, and a quaternary ammonium surfactant.

公开(公告)号：US20230190712A1

公开(公告)日：2023-06-22

申请号：US18172855

申请日：2023-02-22

Applicant: KOWA COMPANY, LTD.

Inventor： Shin SUGIMOTO ,  Akito MINAMIZONO

IPC: A61K31/423 ,  A61K47/02 ,  A61K47/10 ,  A61K47/20 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38

CPC classification number: A61K31/423 ,  A61K47/02 ,  A61K47/10 ,  A61K47/20 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38 ,  A61K9/16

Abstract: Provided is a pharmaceutical composition containing pemafibrate, a salt thereof or a solvate thereof and having excellent homogeneity. The pharmaceutical composition is provided to contain the following components (A) and (B): (A) pemafibrate, a salt thereof or a solvate thereof; and (B) one or more selected from the group consisting of the following components (B-1) to (B-6): (B-1) a cellulose ether species; (B-2) a starch species; (B-3) a povidone species; (B-4) a silicic acid compound; (B-5) a polyhydric alcohol; and (B-6) an alkyl sulfate ester.

公开(公告)号：US20170266080A1

公开(公告)日：2017-09-21

申请号：US15514020

申请日：2015-09-25

Applicant: KOWA COMPANY, LTD.

Inventor： Shin SUGIMOTO

IPC: A61J1/14 ,  A61K9/08 ,  A61K31/551

CPC classification number: A61J1/1468 ,  A61K9/08 ,  A61K31/551

Abstract: A technique is provided for suppressing discoloration of an aqueous composition containing a halogenated isoquinoline derivative during preservation at high temperature. A pharmaceutical preparation obtained by storing an aqueous composition comprising a compound represented by Formula (1), wherein X represents a halogen atom, or a salt thereof, or a solvate of the compound or the salt thereof, in a container made of polyolefin-based resin.

公开(公告)号：US20220096443A1

公开(公告)日：2022-03-31

申请号：US17418518

申请日：2019-12-27

Applicant: KOWA COMPANY, LTD.

Inventor： Shin SUGIMOTO ,  Akito MINAMIZONO ,  Chisa NISHIDA

IPC: A61K31/423 ,  A61K47/32 ,  A61K47/38

Abstract: Provided is a pharmaceutical composition containing pemafibrate, a salt thereof or a solvate thereof and having excellent homogeneity. The pharmaceutical composition is provided to contain the following components (A) and (B): (A) pemafibrate, a salt thereof or a solvate thereof; and (B) one or more selected from the group consisting of the following components (B-1) and (B-7): (B-1) an alkylcellulose and a salt thereof; and a (meth)acrylic acid-based polymer.

公开(公告)号：US20200179346A1

公开(公告)日：2020-06-11

申请号：US16627128

申请日：2018-06-29

Applicant: KOWA COMPANY, LTD.

Inventor： Shin SUGIMOTO ,  Akito MINAMIZONO

IPC: A61K31/423 ,  A61K9/20 ,  A61K47/38 ,  A61K47/20 ,  A61K47/32 ,  A61K47/26 ,  A61K47/02

Abstract: Provided is a pharmaceutical composition containing pemafibrate, a salt thereof or a solvate thereof and having excellent homogeneity. The pharmaceutical composition contains pemafibrate, a salt thereof or a solvate thereof in an amount of 0.017 to 4.2 mass % in terms of a free form of pemafibrate with respect to the total mass of the pharmaceutical composition.

公开(公告)号：US20220151996A1

公开(公告)日：2022-05-19

申请号：US17591108

申请日：2022-02-02

Applicant: KOWA COMPANY, LTD.

Inventor： Shin SUGIMOTO ,  Akito MINAMIZONO

IPC: A61K31/423

Abstract: Provided is a pharmaceutical composition which contains pemafibrate, a salt thereof or a solvate thereof and has excellent stability. A pharmaceutical composition is provided containing pemafibrate, a salt thereof or a solvate thereof and having a moisture content of 2.4 mass % or less.

公开(公告)号：US20200155514A1

公开(公告)日：2020-05-21

申请号：US16627141

申请日：2018-06-29

Applicant: KOWA COMPANY, LTD.

Inventor： Shin SUGIMOTO ,  Akito MINAMIZONO

IPC: A61K31/423 ,  A61K47/26 ,  A61K47/38

Abstract: Provided is a pharmaceutical composition containing pemafibrate, a salt thereof or a solvate thereof and having excellent homogeneity. The pharmaceutical composition is provided containing the following components (A) and (B): (A) pemafibrate, a salt thereof or a solvate thereof; and (B) a disaccharide species.