公开(公告)号：US20230190712A1

公开(公告)日：2023-06-22

申请号：US18172855

申请日：2023-02-22

Applicant: KOWA COMPANY, LTD.

Inventor： Shin SUGIMOTO ,  Akito MINAMIZONO

IPC: A61K31/423 ,  A61K47/02 ,  A61K47/10 ,  A61K47/20 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38

CPC classification number: A61K31/423 ,  A61K47/02 ,  A61K47/10 ,  A61K47/20 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38 ,  A61K9/16

Abstract: Provided is a pharmaceutical composition containing pemafibrate, a salt thereof or a solvate thereof and having excellent homogeneity. The pharmaceutical composition is provided to contain the following components (A) and (B): (A) pemafibrate, a salt thereof or a solvate thereof; and (B) one or more selected from the group consisting of the following components (B-1) to (B-6): (B-1) a cellulose ether species; (B-2) a starch species; (B-3) a povidone species; (B-4) a silicic acid compound; (B-5) a polyhydric alcohol; and (B-6) an alkyl sulfate ester.

公开(公告)号：US20200222370A1

公开(公告)日：2020-07-16

申请号：US16627061

申请日：2018-06-29

Applicant: KOWA COMPANY, LTD.

Inventor： Yuki KUROIWA ,  Akito MINAMIZONO

IPC: A61K31/423

Abstract: Provided is a pharmaceutical composition containing pemafibrate, a salt thereof or a solvate thereof and having excellent storage stability. The pharmaceutical composition is provided to contain pemafibrate, a salt thereof or a solvate thereof, wherein a pH value of a solution produced by dissolving or dispersing the pharmaceutical composition in water is 7 or more.

公开(公告)号：US20220151996A1

公开(公告)日：2022-05-19

申请号：US17591108

申请日：2022-02-02

Applicant: KOWA COMPANY, LTD.

Inventor： Shin SUGIMOTO ,  Akito MINAMIZONO

IPC: A61K31/423

Abstract: Provided is a pharmaceutical composition which contains pemafibrate, a salt thereof or a solvate thereof and has excellent stability. A pharmaceutical composition is provided containing pemafibrate, a salt thereof or a solvate thereof and having a moisture content of 2.4 mass % or less.

公开(公告)号：US20200155514A1

公开(公告)日：2020-05-21

申请号：US16627141

申请日：2018-06-29

Applicant: KOWA COMPANY, LTD.

Inventor： Shin SUGIMOTO ,  Akito MINAMIZONO

IPC: A61K31/423 ,  A61K47/26 ,  A61K47/38

Abstract: Provided is a pharmaceutical composition containing pemafibrate, a salt thereof or a solvate thereof and having excellent homogeneity. The pharmaceutical composition is provided containing the following components (A) and (B): (A) pemafibrate, a salt thereof or a solvate thereof; and (B) a disaccharide species.

公开(公告)号：US20230414578A1

公开(公告)日：2023-12-28

申请号：US18244628

申请日：2023-09-11

Applicant: KOWA COMPANY, LTD.

Inventor： Akito MINAMIZONO

IPC: A61K31/423 ,  A61K9/28

CPC classification number: A61K31/423 ,  A61K9/2813 ,  A61K9/282

Abstract: Provided is a pharmaceutical composition which contains pemafibrate, a salt thereof or a solvate thereof and one or more selected from the group consisting of a metal oxide, a dihydric alcohol, an ester species and a silicic acid compound and which has excellent storage stability. The pharmaceutical composition includes the following components (A) and (B): (A) pemafibrate, a salt thereof or a solvate thereof; and (B) one or more selected from the group consisting of the following components (B-1) to (B-4): (B-1) a metal oxide; (B-2) a dihydric alcohol; (B-3) an ester species; and (B-4) a silicic acid compound, with component (A) and component (B) being substantially in non-contact with each other.

公开(公告)号：US20220096443A1

公开(公告)日：2022-03-31

申请号：US17418518

申请日：2019-12-27

Applicant: KOWA COMPANY, LTD.

Inventor： Shin SUGIMOTO ,  Akito MINAMIZONO ,  Chisa NISHIDA

IPC: A61K31/423 ,  A61K47/32 ,  A61K47/38

Abstract: Provided is a pharmaceutical composition containing pemafibrate, a salt thereof or a solvate thereof and having excellent homogeneity. The pharmaceutical composition is provided to contain the following components (A) and (B): (A) pemafibrate, a salt thereof or a solvate thereof; and (B) one or more selected from the group consisting of the following components (B-1) and (B-7): (B-1) an alkylcellulose and a salt thereof; and a (meth)acrylic acid-based polymer.

公开(公告)号：US20200179346A1

公开(公告)日：2020-06-11

申请号：US16627128

申请日：2018-06-29

Applicant: KOWA COMPANY, LTD.

Inventor： Shin SUGIMOTO ,  Akito MINAMIZONO

IPC: A61K31/423 ,  A61K9/20 ,  A61K47/38 ,  A61K47/20 ,  A61K47/32 ,  A61K47/26 ,  A61K47/02

Abstract: Provided is a pharmaceutical composition containing pemafibrate, a salt thereof or a solvate thereof and having excellent homogeneity. The pharmaceutical composition contains pemafibrate, a salt thereof or a solvate thereof in an amount of 0.017 to 4.2 mass % in terms of a free form of pemafibrate with respect to the total mass of the pharmaceutical composition.