公开(公告)号：US20090298700A1

公开(公告)日：2009-12-03

申请号：US11910313

申请日：2006-03-31

申请人： Kazuyasu Sakaguchi ,  Yoshiro Chuman ,  Yasuo Akebiyama ,  Miho Matsukizono ,  Maki Watanabe ,  Junichi Tsutumi

发明人： Kazuyasu Sakaguchi ,  Yoshiro Chuman ,  Yasuo Akebiyama ,  Miho Matsukizono ,  Maki Watanabe ,  Junichi Tsutumi

IPC分类号： C40B30/00 ,  C07K16/00 ,  C12N5/06 ,  C40B40/10

CPC分类号： C07K16/18 ,  C07K7/06 ,  C07K7/08 ,  G01N33/5748 ,  G01N2333/4748

摘要： The present invention provides a monoclonal antibody recognizing modification after translation of p53 in a manner specific to a modification site, an antibody microarray comprising the antibody immobilized on a substrate, etc. Disclosed is a monoclonal antibody which reacts specifically with a peptide consisting of an amino acid sequence of at least 6 consecutive amino acids containing a predetermined amino acid residue of the amino acid sequence represented by SEQ ID NO: 1, wherein the amino acid residue is phosphorylated or acetylated, or with a peptide having one to several arbitrary amino acids added to the above peptide, but does not react with the above peptide which is not phosphorylated or acetylated.

摘要翻译： 本发明提供了以对修饰位点特异性的方式翻译p53后的单克隆抗体，包含固定在底物上的抗体的抗体微阵列等。公开了与由氨基组成的肽特异性反应的单克隆抗体 含有由SEQ ID NO：1表示的氨基酸序列的预定氨基酸残基的至少6个连续氨基酸的酸序列，其中所述氨基酸残基被磷酸化或乙酰化，或者与具有一至几个任意氨基酸的肽相加 但不与未被磷酸化或乙酰化的上述肽反应。

公开(公告)号：US08062887B2

公开(公告)日：2011-11-22

申请号：US11910313

申请日：2006-03-31

申请人： Kazuyasu Sakaguchi ,  Yoshiro Chuman ,  Yasuo Akebiyama ,  Miho Matsukizono ,  Maki Watanabe ,  Junichi Tsutsumi

发明人： Kazuyasu Sakaguchi ,  Yoshiro Chuman ,  Yasuo Akebiyama ,  Miho Matsukizono ,  Maki Watanabe ,  Junichi Tsutsumi

IPC分类号： C12N5/12 ,  C07K16/18

CPC分类号： C07K16/18 ,  C07K7/06 ,  C07K7/08 ,  G01N33/5748 ,  G01N2333/4748

摘要： The present invention provides a monoclonal antibody recognizing modification after translation of p53 in a manner specific to a modification site, an antibody microarray comprising the antibody immobilized on a substrate, etc. Disclosed is a monoclonal antibody which reacts specifically with a peptide consisting of an amino acid sequence of at least 6 consecutive amino acids containing a predetermined amino acid residue of the amino acid sequence represented by SEQ ID NO: 1, wherein the amino acid residue is phosphorylated or acetylated, or with a peptide having one to several arbitrary amino acids added to the above peptide, but does not react with the above peptide which is not phosphorylated or acetylated.

摘要翻译： 本发明提供了以对修饰位点特异性的方式翻译p53后的单克隆抗体，包含固定在底物上的抗体的抗体微阵列等。公开了与由氨基组成的肽特异性反应的单克隆抗体 含有由SEQ ID NO：1表示的氨基酸序列的预定氨基酸残基的至少6个连续氨基酸的酸序列，其中所述氨基酸残基被磷酸化或乙酰化，或者与具有一至几个任意氨基酸的肽相加 但不与未被磷酸化或乙酰化的上述肽反应。

公开(公告)号：US06530091B2

公开(公告)日：2003-03-11

申请号：US10013900

申请日：2001-10-30

申请人： Hisashi Takai ,  Miou Suzuki ,  Kaori Yamauchi ,  Maki Watanabe ,  Sachiyo Suzuki

发明人： Hisashi Takai ,  Miou Suzuki ,  Kaori Yamauchi ,  Maki Watanabe ,  Sachiyo Suzuki

IPC分类号： A61F1315

CPC分类号： A61F13/505 ,  A61F13/56 ,  A61F13/5611

摘要： Support for attaching an absorbent article such as a sanitary napkin to an undergarment and disposed between a sanitary napkin and an inner surface of a crotch region of the undergarment. The support is formed by a first sheet and a second sheet overlying the first sheet. The first sheet 6 is elastically flexible and stretchable in its longitudinal direction and the second sheet has its longitudinally opposite end portions bonded to longitudinally opposite end portions of the first sheet and elastically stretchable at least in the longitudinal direction. The inner surface of the second sheet is formed so that the outer surface of the napkin may be fixed thereon.

摘要翻译： 支撑用于将诸如卫生巾的吸收制品附接到内衣并且设置在卫生巾和内衣的裆部区域的内表面之间。 支撑体由覆盖第一片材的第一片材​​和第二片材形成。 第一片6在其纵向具有弹性柔性和可拉伸性，并且第二片的纵向相对的端部粘合到第一片的纵向相对端部并且至少在纵向上可弹性伸展。 第二片的内表面形成为可以将卫生巾的外表面固定在其上。

公开(公告)号：US07015370B2

公开(公告)日：2006-03-21

申请号：US10634081

申请日：2003-08-04

申请人： Maki Watanabe ,  Miou Suzuki ,  Masashi Nakashita

发明人： Maki Watanabe ,  Miou Suzuki ,  Masashi Nakashita

IPC分类号： A61F13/537 ,  A61F13/15

CPC分类号： A61F13/512 ,  A61F13/534 ,  A61F13/535 ,  A61F13/53747 ,  A61F2013/53734 ,  A61F2013/53778 ,  A61F2013/53782

摘要： A wearing article absorption of body fluids has an inner sheet, an outer sheet and a body fluid absorbent first panel underlying the inner sheet. The inner sheet and the first panel are formed in central regions thereof with a void to be filled with a hydrophobic second panel which is elastically compressible and liquid-pervious. A plurality of narrow strips, each comprising water-absorbent fibers compressed to a high density, and a hydrophobic and liquid-pervious spacer member underlying the narrow strips are interposed between the second panel and the outer sheet.

摘要翻译： 磨损物体吸收体液具有内片，外片和位于内片下面的体液吸收性第一片。 内片和第一片在其中央区域形成有空隙，填充有可弹性压缩且透液的疏水性第二片。 每个包含被压缩到高密度的吸水性纤维的多个窄带以及窄条下面的疏水性和透液性隔离构件设置在第二面板和外层之间。

公开(公告)号：US20050256491A1

公开(公告)日：2005-11-17

申请号：US11109694

申请日：2005-04-20

申请人： Maki Watanabe ,  Ichiro Wada

发明人： Maki Watanabe ,  Ichiro Wada

IPC分类号： A41B9/12 ,  A61F13/15 ,  A61F13/20 ,  A61F13/472 ,  A61F13/56 ,  A61F13/72 ,  A61F13/74 ,  A61F13/78

CPC分类号： A61F13/49473 ,  A61F13/495 ,  A61F13/505 ,  A61F13/72 ,  A61F13/78 ,  A61F2013/51429

摘要： A wearing article includes pants having a supporting sheet extending between front and rear waist regions and a body waste absorbing pad formed in its upper surface with a first opening and releasably attached to the inner side of the pants. The supporting sheet is formed with a slit through which a rear zone of the pad can be inserted. The pad is provided on its upper surface with a joined sheet having a second opening. A front zone and an intermediate zone of the pad are placed on the upper surface of the supporting sheet, the rear zone of the pad is inserted into the slit so as to be interposed between the pants and the supporting sheet, free front and rear zones are fastened to the upper surface of the supporting sheet and thereby the pad is attached to the pants by means of the supporting sheet.

摘要翻译： 穿着物品包括具有在前腰围区域和后腰围区域之间延伸的支撑片材的裤子和在其上表面上形成有第一开口并且可释放地附接到裤子内侧的身体排泄物吸收垫。 支撑片形成有狭缝，垫的后区可以穿过该狭缝插入。 垫在其上表面上设置有具有第二开口的接合片。 垫的前部区域和中间区域被放置在支撑片材的上表面上，衬垫的后部区域插入狭缝中以便插入在裤子和支撑片材之间，自由的前后区域 被紧固到支撑片的上表面，从而通过支撑片将垫附接到裤子。

公开(公告)号：US07387620B2

公开(公告)日：2008-06-17

申请号：US11109694

申请日：2005-04-20

申请人： Maki Watanabe ,  Ichiro Wada

发明人： Maki Watanabe ,  Ichiro Wada

IPC分类号： A61F13/15

CPC分类号： A61F13/49473 ,  A61F13/495 ,  A61F13/505 ,  A61F13/72 ,  A61F13/78 ,  A61F2013/51429

摘要： A wearing article includes pants having a supporting sheet extending between front and rear waist regions and a body waste absorbing pad formed in its upper surface with a first opening and releasably attached to the inner side of the pants. The supporting sheet is formed with a slit through which a rear zone of the pad can be inserted. The pad is provided on its upper surface with a joined sheet having a second opening. A front zone and an intermediate zone of the pad are placed on the upper surface of the supporting sheet, the rear zone of the pad is inserted into the slit so as to be interposed between the pants and the supporting sheet, free front and rear zones are fastened to the upper surface of the supporting sheet and thereby the pad is attached to the pants by means of the supporting sheet.

摘要翻译： 穿着物品包括具有在前腰围区域和后腰围区域之间延伸的支撑片材的裤子和在其上表面上形成有第一开口并且可释放地附接到裤子内侧的身体排泄物吸收垫。 支撑片形成有狭缝，垫的后区可以穿过该狭缝插入。 垫在其上表面上设置有具有第二开口的接合片。 垫的前部区域和中间区域被放置在支撑片材的上表面上，衬垫的后部区域插入狭缝中以便插入在裤子和支撑片材之间，自由的前后区域 被紧固到支撑片的上表面，从而通过支撑片将垫附接到裤子。

公开(公告)号：US06168924A

公开(公告)日：2001-01-02

申请号：US08954792

申请日：1997-10-21

申请人： Hiroshi Tamura ,  Shigenori Tanaka ,  Maki Watanabe

发明人： Hiroshi Tamura ,  Shigenori Tanaka ,  Maki Watanabe

IPC分类号： G01N3353

CPC分类号： G01N33/579 ,  Y10S436/825 ,  Y10T436/25125

摘要： The presence of endotoxin in the outer membrane of cell wall of a Gram-negative bacteria is used to determine bacterial contamination in a biological product. The amount of endotoxin present in a biological product is accurately measured without influence of a limulus reaction-activating substance which causes a false-positive reaction, by a method including the steps of: inactivating the limulus reaction-activating substance, if any, in the biological product, by exposing the biological product to a surfactant at a temperature ranging from the surfactant's freezing point to 50° C.; and measuring the amount of endotoxin present in the biological product, using a limulus reagent.

摘要翻译： 使用革兰氏阴性细菌细胞壁外膜内毒素的存在来确定生物制品中的细菌污染。 存在于生物制品中的内毒素的量在不影响引起假阳性反应的鲎反应活化物质的情况下被精确测量，方法包括以下步骤：使鲎反应活化物质（如果有的话）灭活 通过在表面活性剂的凝固点至50℃​​的温度下将生物产物暴露于表面活性剂中来生物制品。 并使用鲎试剂测量生物制品中存在的内毒素的量。

公开(公告)号：US07125400B2

公开(公告)日：2006-10-24

申请号：US10849938

申请日：2004-05-21

申请人： Takamitsu Igaue ,  Maki Watanabe

发明人： Takamitsu Igaue ,  Maki Watanabe

IPC分类号： A61F13/62 ,  A44B18/00 ,  A41B9/00

CPC分类号： A61F13/49015 ,  A61F13/5633 ,  A61F13/625 ,  Y10T24/27

摘要： A wearing article such as a disposable diaper is provided in predetermined regions of the article with hook members. These predetermined regions are elastically stretchable at least in one direction. Each of the hook members includes a plurality of hook assemblies which are, in turn, attached to each of the predetermined regions so as to be spaced apart one from another in the one direction.

摘要翻译： 在具有钩构件的物品的预定区域中设置诸如一次性尿布的穿着物品。 这些预定区域至少在一个方向上是可弹性拉伸的。 每个钩构件包括多个钩组件，这些钩组件依次连接到每个预定区域，以便在一个方向上彼此间隔开。