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1.发明申请MONOCLONAL ANTIBODY SPECIFICALLY RECOGNIZING MODIFICATION SITE AFTER TRANSLATION OF P53 AND KIT FOR ASSAYING MODIFICATION SITE CONTAINING THE SAME 有权单克隆抗体在翻译P53和试剂盒之后特别确认修饰位点，用于测定其同样的修饰位点公开(公告)号：US20090298700A1
公开(公告)日：2009-12-03
申请号：US11910313
申请日：2006-03-31
申请人： Kazuyasu Sakaguchi , Yoshiro Chuman , Yasuo Akebiyama , Miho Matsukizono , Maki Watanabe , Junichi Tsutumi
发明人： Kazuyasu Sakaguchi , Yoshiro Chuman , Yasuo Akebiyama , Miho Matsukizono , Maki Watanabe , Junichi Tsutumi
CPC分类号： C07K16/18 , C07K7/06 , C07K7/08 , G01N33/5748 , G01N2333/4748
摘要： The present invention provides a monoclonal antibody recognizing modification after translation of p53 in a manner specific to a modification site, an antibody microarray comprising the antibody immobilized on a substrate, etc. Disclosed is a monoclonal antibody which reacts specifically with a peptide consisting of an amino acid sequence of at least 6 consecutive amino acids containing a predetermined amino acid residue of the amino acid sequence represented by SEQ ID NO: 1, wherein the amino acid residue is phosphorylated or acetylated, or with a peptide having one to several arbitrary amino acids added to the above peptide, but does not react with the above peptide which is not phosphorylated or acetylated.
摘要翻译： 本发明提供了以对修饰位点特异性的方式翻译p53后的单克隆抗体，包含固定在底物上的抗体的抗体微阵列等。公开了与由氨基组成的肽特异性反应的单克隆抗体 含有由SEQ ID NO：1表示的氨基酸序列的预定氨基酸残基的至少6个连续氨基酸的酸序列，其中所述氨基酸残基被磷酸化或乙酰化，或者与具有一至几个任意氨基酸的肽相加 但不与未被磷酸化或乙酰化的上述肽反应。
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2.发明授权Monoclonal antibody specifically recognizing modification site after translation of p53 and kit for assaying modification site containing the same 有权特异性识别p53翻译后的修饰位点的单克隆抗体和用于测定含有该修饰位点的试剂盒公开(公告)号：US08062887B2
公开(公告)日：2011-11-22
申请号：US11910313
申请日：2006-03-31
申请人： Kazuyasu Sakaguchi , Yoshiro Chuman , Yasuo Akebiyama , Miho Matsukizono , Maki Watanabe , Junichi Tsutsumi
发明人： Kazuyasu Sakaguchi , Yoshiro Chuman , Yasuo Akebiyama , Miho Matsukizono , Maki Watanabe , Junichi Tsutsumi
CPC分类号： C07K16/18 , C07K7/06 , C07K7/08 , G01N33/5748 , G01N2333/4748
摘要： The present invention provides a monoclonal antibody recognizing modification after translation of p53 in a manner specific to a modification site, an antibody microarray comprising the antibody immobilized on a substrate, etc. Disclosed is a monoclonal antibody which reacts specifically with a peptide consisting of an amino acid sequence of at least 6 consecutive amino acids containing a predetermined amino acid residue of the amino acid sequence represented by SEQ ID NO: 1, wherein the amino acid residue is phosphorylated or acetylated, or with a peptide having one to several arbitrary amino acids added to the above peptide, but does not react with the above peptide which is not phosphorylated or acetylated.
摘要翻译： 本发明提供了以对修饰位点特异性的方式翻译p53后的单克隆抗体，包含固定在底物上的抗体的抗体微阵列等。公开了与由氨基组成的肽特异性反应的单克隆抗体 含有由SEQ ID NO：1表示的氨基酸序列的预定氨基酸残基的至少6个连续氨基酸的酸序列，其中所述氨基酸残基被磷酸化或乙酰化，或者与具有一至几个任意氨基酸的肽相加 但不与未被磷酸化或乙酰化的上述肽反应。
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公开(公告)号：US08759323B2
公开(公告)日：2014-06-24
申请号：US13123166
申请日：2009-10-02
IPC分类号： A01N55/00 , A61K31/695 , C07F7/04 , C07F7/08
CPC分类号： A61K31/695 , C07F7/1804
摘要： Provided is a novel protein phosphatase inhibitor. The protein phosphatase inhibitor contains, as an active ingredient, a silicon compound represented by the following general formula (1) or a salt thereof, wherein R1, R2 and R3 are the same or different and represent a hydrocarbon group having 1 to 12 carbon atoms; X represents an optionally substituted hydrocarbon group having 3 to 36 carbon atoms or an optionally substituted heterocyclic group; and n represents an integer of 0 or 1.
摘要翻译： 提供了一种新型蛋白磷酸酶抑制剂。 蛋白质磷酸酶抑制剂含有作为活性成分的由以下通式（1）表示的硅化合物或其盐，其中R1，R2和R3相同或不同，表示碳原子数1〜12的烃基 ; X表示具有3〜36个碳原子的任选取代的烃基或任选取代的杂环基; n表示0或1的整数。
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公开(公告)号：US20110288050A1
公开(公告)日：2011-11-24
申请号：US13123166
申请日：2009-10-02
IPC分类号： A61K31/695 , A61P35/00 , C07F7/18
CPC分类号： A61K31/695 , C07F7/1804
摘要： Provided is a novel protein phosphatase inhibitor. The protein phosphatase inhibitor contains, as an active ingredient, a silicon compound represented by the following general formula (1) or a salt thereof, wherein R1, R2 and R3 are the same or different and represent a hydrocarbon group having 1 to 12 carbon atoms; X represents an optionally substituted hydrocarbon group having 3 to 36 carbon atoms or an optionally substituted heterocyclic group; and n represents an integer of 0 or 1.
摘要翻译： 提供了一种新型蛋白磷酸酶抑制剂。 蛋白质磷酸酶抑制剂含有作为活性成分的由以下通式（1）表示的硅化合物或其盐，其中R1，R2和R3相同或不同，表示碳原子数1〜12的烃基 ; X表示具有3〜36个碳原子的任选取代的烃基或任选取代的杂环基; n表示0或1的整数。
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