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公开(公告)号：US20110020926A1
公开(公告)日：2011-01-27
申请号：US12896676
申请日：2010-10-01
申请人： Keiko ABE , Tomiko Asakura , Hiroyuki Sorimachi , Tazuko Uenoyama , Kenichiro Nakajima , Katsuhiko Kitamoto , Junichi Maruyama , Mikiya Kishi
发明人： Keiko ABE , Tomiko Asakura , Hiroyuki Sorimachi , Tazuko Uenoyama , Kenichiro Nakajima , Katsuhiko Kitamoto , Junichi Maruyama , Mikiya Kishi
摘要： Disclosed is a polypeptide shown below in (A) or (B), a protein dimer neoculin comprising the polypeptide Neoculin Acidic Subunit (NAS) and the polypeptide Neoculin Basic Subunit (NBS) and having a taste-modifying activity: (A) a polypeptide comprising an amino acid sequence shown in SEQ ID NO.2 in the sequence listing; (B) a polypeptide comprising an amino acid sequence with the substitution, deletion, insertion, addition or inversion of one or several amino acids in the amino acid sequence shown in SEQ ID NO. 2 in the sequence listing, which polypeptide can form the neoculin dimer having a taste-modifying activity together with the polypeptide NBS.
摘要翻译： 公开了下述（A）或（B）所示的多肽，其包含多肽新霉素酸性亚基（NAS）和多肽新霉素碱基亚基（NBS）并具有调味活性的蛋白质二聚体新霉素：（A）多肽 包含序列表中SEQ ID NO：2所示的氨基酸序列; （B）包含SEQ ID NO：1所示的氨基酸序列中的一个或几个氨基酸的取代，缺失，插入，添加或倒位的氨基酸序列的多肽。 2，该多肽可以与多肽NBS一起形成具有调味活性的新霉素二聚体。
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公开(公告)号：US08043851B2
公开(公告)日：2011-10-25
申请号：US12896676
申请日：2010-10-01
申请人： Keiko Abe , Tomiko Asakura , Hiroyuki Sorimachi , Tazuko Uenoyama , Kenichiro Nakajima , Katsuhiko Kitamoto , Junichi Maruyama , Mikiya Kishi
发明人： Keiko Abe , Tomiko Asakura , Hiroyuki Sorimachi , Tazuko Uenoyama , Kenichiro Nakajima , Katsuhiko Kitamoto , Junichi Maruyama , Mikiya Kishi
摘要： Disclosed is a polypeptide shown in the following in (A), and a protein dimer neoculin comprising the polypeptide Neoculin Acidic Subunit (NAS) and the polypeptide Neoculin Basic Subunit (NBS) and having a taste-modifying activity: (A) a polypeptide comprising an amino acid sequence shown in SEQ ID NO.2 in the sequence listing.
摘要翻译： 公开了以下（A）中所示的多肽和包含多肽新霉素酸性亚基（NAS）和多肽新霉素基础亚基（NBS）并具有调味活性的蛋白质二聚体新霉素：（A）包含 序列表中SEQ ID NO：2所示的氨基酸序列。
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3.发明申请公开(公告)号：US20080305522A1
公开(公告)日：2008-12-11
申请号：US10587539
申请日：2005-01-27
申请人： Keiko Abe , Tomiko Asakura , Hiroyuki Sorimachi , Tazuko Uenoyama , Kenichiro Nakajima , Katsuhiko Kitamoto , Junichi Maruyama , Mikiya Kishi
发明人： Keiko Abe , Tomiko Asakura , Hiroyuki Sorimachi , Tazuko Uenoyama , Kenichiro Nakajima , Katsuhiko Kitamoto , Junichi Maruyama , Mikiya Kishi
摘要： It is an object of the invention to find a substance with a better taste-modifying function and determine the structure of the taste-modifying substance, as well as to elucidate the structure thereof at a gene level and determine the primary structure of the substance and obtain the gene encoding the substance. Additionally, it is an object of the invention to provide a novel taste-modifying composition characteristically containing the taste-modifying substance.Specifically, the invention provides the polypeptide shown below in (A) or (B), a protein dimer neoculin comprising the polypeptide NAS and the polypeptide NBS and having a taste-modifying activity:(A) a polypeptide comprising an amino acid sequence shown in SEQ ID NO.2 in the sequence listing; (B) a polypeptide comprising an amino acid sequence with the substitution, deletion, insertion, addition or inversion of one or several amino acids in the amino acid sequence shown in SEQ ID NO.2 in the sequence listing, which polypeptide can form the neoculin dimer having a taste-modifying activity together with the polypeptide NBS.
摘要翻译： 本发明的目的是找到具有更好的味觉调节功能的物质并确定调味物质的结构，以及阐明其在基因水平上的结构并确定该物质的一级结构和 获得编码该物质的基因。 此外，本发明的目的是提供一种特征性地含有味道调节物质的新颖的味道改良组合物。 具体而言，本发明提供下述（A）或（B）所示的多肽，包含多肽NAS和多肽NBS并具有调味活性的蛋白质二聚体新霉素：（A）包含氨基酸序列 序列表中SEQ ID NO：2; （B）包含在序列表中SEQ ID NO.2所示的氨基酸序列中的一个或几个氨基酸的取代，缺失，插入，添加或倒位的氨基酸序列的多肽，该多肽可以形成新霉素 二聚体与多肽NBS一起具有调味活性。
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