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Patent Agency Ranking
1.发明授权公开(公告)号：US11181531B2
公开(公告)日：2021-11-23
申请号：US16078333
申请日：2017-12-15
Applicant: Korea Basic Science Institute
Inventor： Gun Wook Park , Jong Shin Yoo , Jin Young Kim , Ju Yeon Lee , Hyun Kyoung Lee
Abstract: The present invention relates to a bioinformation processing analysis method for the identification and quantification of O-linked glycopeptide using high resolution mass spectrum. Particularly, according to the bioinformation processing analysis method of the present invention, the quantitative changes of O-linked glycopeptide containing non-informed sugar chains included in various samples can be efficiently and accurately analyzed; the prediction or diagnosis of disease including cancer can be made easy by using a high resolution mass spectrometer; or the investigation of O-linked glycopeptide structure of a therapeutic glycoprotein can be efficiently achieved.
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2.发明申请公开(公告)号：US20200018759A1
公开(公告)日：2020-01-16
申请号：US15545552
申请日：2017-04-27
Applicant: KOREA BASIC SCIENCE INSTITUTE
Inventor： Jong Shin Yoo , Kwang Hoe Kim , Jin Young Kim , Ju Yeon Lee
IPC: G01N33/574 , G01N33/68
Abstract: The present invention relates to a diagnosis method of liver cancer using mass spectrometry of α-fetoprotein derived glycopeptide. Particularly, according to the AFP glycopeptide analysis method of the invention, fucosylation rate of the glycopeptide having the sequence composed of Val-Asn-Phe-Thr-Glu-Ile-Gln-Lys is analyzed to diagnose liver cancer in the early developmental grade. In particular, fucosylation rate is higher in the liver cancer patients than in other liver disease patients, so that the comparison of the fucosylation rate can be useful to diagnose or distinguish liver cancer from other liver diseases in the early HCC patients.
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3.发明授权公开(公告)号：US10697971B2
公开(公告)日：2020-06-30
申请号：US15545552
申请日：2017-04-27
Applicant: KOREA BASIC SCIENCE INSTITUTE
Inventor： Jong Shin Yoo , Kwang Hoe Kim , Jin Young Kim , Ju Yeon Lee
IPC: G01N33/574 , G01N33/68
Abstract: The present invention relates to a diagnosis method of liver cancer using mass spectrometry of α-fetoprotein derived glycopeptide. Particularly, according to the AFP glycopeptide analysis method of the invention, fucosylation rate of the glycopeptide having the sequence composed of Val-Asn-Phe-Thr-Glu-Ile-Gln-Lys is analyzed to diagnose liver cancer in the early developmental grade. In particular, fucosylation rate is higher in the liver cancer patients than in other liver disease patients, so that the comparison of the fucosylation rate can be useful to diagnose or distinguish liver cancer from other liver diseases in the early HCC patients.
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4.发明授权Bioinformatics platform for high-throughput identification and quantification of N—glycopeptide 有权用于高通量鉴定和定量的N-糖肽的生物信息学平台公开(公告)号：US09436797B2
公开(公告)日：2016-09-06
申请号：US13884233
申请日：2013-01-22
Applicant: Korea Basic Science Institute
Inventor： Gun Wook Park , Jong Shin Yoo , Jin Young Kim , Ju Yeon Lee , Hyun Kyoung Lee , Hyun Joo An , Jae-Han Kim
CPC classification number: G06F19/16 , C12Q1/37 , G01N30/86 , G01N33/6848 , G01N2030/8813 , G01N2030/8831 , G01N2400/00 , G01N2440/38 , G01N2560/00 , G01N2570/00 , H01J49/0027 , H01J49/0036 , H01J49/004
Abstract: The present invention relates to a more efficient and accurate method for the identification and quantification of comparatively low abundant glycopeptides, compared with general peptides, using mass spectrum obtained by using high resolution mass spectrometer. Therefore, the method of the present invention can be effectively used for the techniques for identification of biotherapeutics and diagnosis of cancer or disease by screening glycopeptide, the disease marker (Biomarker), from various samples.
Abstract translation: 本发明涉及使用通过使用高分辨率质谱仪获得的质谱，与一般肽相比，用于鉴定和定量相对低丰度糖肽的更有效和准确的方法。 因此，通过从各种样品中筛选糖肽（疾病标记物（Biomarker）），本发明的方法可以有效地用于识别生物治疗剂和癌症或疾病的诊断技术。
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5.发明申请Bioinformatics Platform for High-Throughput Identification and Quantification of N--Glycopeptide 有权用于高通量鉴定和定量的N-糖肽的生物信息学平台公开(公告)号：US20150186595A1
公开(公告)日：2015-07-02
申请号：US13884233
申请日：2013-01-22
Applicant: Korea Basic Science Institute
Inventor： Gun Wook Park , Jong Shin Yoo , Jin Young Kim , Ju Yeon Lee , Hyun Kyoung Lee , Hyun Joo An , Jae-Han Kim
CPC classification number: G06F19/16 , C12Q1/37 , G01N30/86 , G01N33/6848 , G01N2030/8813 , G01N2030/8831 , G01N2400/00 , G01N2440/38 , G01N2560/00 , G01N2570/00 , H01J49/0027 , H01J49/0036 , H01J49/004
Abstract: The present invention relates to a more efficient and accurate method for the identification and quantification of comparatively low abundant glycopeptides, compared with general peptides, using mass spectrum obtained by using high resolution mass spectrometer. Therefore, the method of the present invention can be effectively used for the techniques for identification of biotherapeutics and diagnosis of cancer or disease by screening glycopeptide, the disease marker (Biomarker), from various samples.
Abstract translation: 本发明涉及使用通过使用高分辨率质谱仪获得的质谱，与一般肽相比，用于鉴定和定量相对低丰度糖肽的更有效和准确的方法。 因此，通过从各种样品中筛选糖肽（疾病标记物（Biomarker）），本发明的方法可以有效地用于识别生物治疗剂和癌症或疾病的诊断技术。
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