公开(公告)号：US09284550B2

公开(公告)日：2016-03-15

申请号：US14446651

申请日：2014-07-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Byoung Chan Kim ,  Yeon Seok Kim ,  Jin Yang Chung ,  Jong Soo Jurng ,  Min Young Song

IPC: C07H21/02 ,  C07H21/04 ,  C12Q1/68 ,  G01N33/50 ,  C12N15/11 ,  G01N33/53 ,  G01N33/569 ,  C12N15/115

CPC classification number: C12N15/11 ,  C12N15/115 ,  C12N2310/16 ,  C12N2310/3181 ,  C12N2320/11 ,  G01N33/5308 ,  G01N33/56916 ,  G01N2333/26

Abstract: Provided is a single-stranded nucleic acid aptamer specifically binding to Klebsiella pneumoniae, and a method for detecting Klebsiella pneumoniae by using the same. The aptamer of the present disclosure, and a method, a composition, a kit or a sensor of using the same may be used to specifically detect Klebsiella pneumoniae present in an aqueous environment, foods, and medical samples and also be applied in fields such as sanitary conditions of foods and medical diagnosis.

Abstract translation: 本发明提供了特异性结合肺炎克雷伯氏杆菌的单链核酸适体和通过使用该克隆氏杆菌检测肺炎克雷伯氏杆菌的方法。 本公开的适体，以及使用其的方法，组合物，试剂盒或传感器可以用于特异性检测存在于水性环境，食品和医用样品中的肺炎克雷伯杆菌，并且也可以应用于例如 食品卫生条件和医疗诊断。

公开(公告)号：US10920266B2

公开(公告)日：2021-02-16

申请号：US16221585

申请日：2018-12-17

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Byoung Chan Kim ,  Jae Hee Jung ,  Hye Ri Kim ,  Yusung Cho ,  Kang Bong Lee

IPC: C12Q1/66 ,  G01N21/76 ,  C12Q1/04 ,  G01N33/573

Abstract: Provided is a device for real-time measurement of bacteria. The device for real-time measurement of bacteria includes reaction portions, a support portion configured to support the reaction portions, a rotational shaft configured to transfer the support portion, and a sample supply portion configured to supply a sample to each of the reaction portions, and according to the device for real-time measurement of bacteria, bacteria may be measured in real time through the detection of ATP.

公开(公告)号：US09034254B2

公开(公告)日：2015-05-19

申请号：US13672399

申请日：2012-11-08

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Byoung Chan Kim ,  Jong Soo Jurng ,  Min Young Song

IPC: A61L2/00 ,  C09K3/00 ,  A61L9/00 ,  G01N33/53 ,  A61L2/10 ,  A61L2/08

CPC classification number: A61L2/10 ,  A61L2/088

Abstract: Disclosed is an antibacterial composition comprising titanium oxide particles immobilized with an antibody having affinity and cognitive power to a microorganism of interest, and a method for sterilizing the microorganism by using the same. In particular, the present invention relates to a method for preparing functional titanium oxide particles capable of recognizing a microorganism or a virus of interest, and a method for selectively and efficiently sterilizing the same by using the functional titanium oxide particles, and not for randomly sterilizing microorganisms or viruses by using conventional titanium oxide particles having no recognition power to a microorganism or a virus of interest.

Abstract translation: 公开了一种抗菌组合物，其包含固定有对感兴趣的微生物具有亲和力和认知能力的抗体的氧化钛颗粒，以及使用该微生物的方法。 特别地，本发明涉及一种能够识别感兴趣的微生物或感兴趣的病毒的功能性氧化钛粒子的方法，以及通过使用所述功能性氧化钛粒子选择性且有效地对其消毒的方法，而不是用于随机灭菌 通过使用对感兴趣的微生物或感兴趣的病毒不具有识别能力的常规氧化钛颗粒的微生物或病毒。

公开(公告)号：US09551709B2

公开(公告)日：2017-01-24

申请号：US14623082

申请日：2015-02-16

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Byoung Chan Kim ,  Min Young Song ,  Jin Yang Chung ,  Jong Soo Jurng

IPC: C07H21/02 ,  G01N33/569 ,  C12N15/10 ,  G01N33/53

CPC classification number: G01N33/56938 ,  C12N15/1048 ,  G01N33/5308 ,  G01N33/56916 ,  G01N2333/245 ,  G01N2333/26 ,  G01N2333/265 ,  G01N2333/31 ,  G01N2333/32

Abstract: Provided are a single-stranded nucleic acid aptamer simultaneously and specifically binding to various types of microorganisms, and a method of manufacturing the nucleic acid aptamer. For example, provided are a probe that is capable of simultaneously detecting or diagnosing a variety of microorganisms, and a method of manufacturing an aptamer having characteristics of such a probe.

Abstract translation: 提供同时且特异性结合各种微生物的单链核酸适体，以及制备核酸适体的方法。 例如，提供能够同时检测或诊断各种微生物的探针，以及制造具有这种探针特征的适体的方法。

公开(公告)号：US08969537B2

公开(公告)日：2015-03-03

申请号：US13752662

申请日：2013-01-29

Applicant: Korea Institute of Science and Technology

Inventor： Byoung Chan Kim ,  Yeon Seok Kim ,  Jong Soo Jurng

IPC: C07H21/02 ,  C12M1/34 ,  C12N15/115 ,  G01N33/569

CPC classification number: C12N15/115 ,  G01N33/56911 ,  G01N33/56916 ,  G01N2333/245

Abstract: Provided are a single-stranded nucleic acid aptamer specifically binding to E. coli and a method for detecting E. coli using the same. The method, kits or sensors of the present disclosure enable E. coli to be specifically detected among microorganisms existing in a water system, but also be applied in fields such as food sanitation or medical diagnosis.

Abstract translation: 提供特异性结合大肠杆菌的单链核酸适体和使用其的大肠杆菌检测方法。 本公开的方法，试剂盒或传感器使得大肠杆菌能够在存在于水系统中的微生物中被特异性检测，但也可应用于食品卫生或医学诊断领域。

公开(公告)号：US20140342467A1

公开(公告)日：2014-11-20

申请号：US13946656

申请日：2013-07-19

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Yeon Seok Kim ,  Jong Soo Jurng ,  Byoung Chan Kim ,  Hyoun Duk Jung ,  Jin Young Kim

IPC: G01N33/18

CPC classification number: G01N33/1813 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/85 ,  G01N2021/773 ,  G01N2021/7786

Abstract: The present invention relates to an apparatus and method for continuously monitoring subaqueous target harmful substances. More particularly, it relates to an apparatus and method for continuously monitoring subaqueous target harmful substances by continuously measuring the concentration of the subaqueous target harmful substances. The present invention provides an apparatus and method for continuously monitoring subaqueous target harmful substances, which can continuously measure the concentration of subaqueous target harmful substances using a receptor that can selectively recognize the target harmful substances, a porous membrane fixed with the receptor, and a sensing unit that continuously measures the intensity of fluorescent signals of the target harmful substance reacting with the receptor, and can be utilized as various apparatuses and methods for continuously sensing various harmful substances necessary to continuously monitor for the management of the water quality.

Abstract translation: 本发明涉及连续监测水中靶标有害物质的装置和方法。 更具体地，涉及通过连续测量水中靶标有害物质的浓度来连续监测水中靶标有害物质的装置和方法。 本发明提供一种用于连续监测水中靶标有害物质的装置和方法，其可以使用能够选择性地识别目标有害物质的受体，用受体固定的多孔膜，连续地测量水中靶标有害物质的浓度，以及感测 能够连续地测量与受体反应的目标有害物质的荧光信号的强度的单位，并且可以用作连续检测持续监测水质管理所需的各种有害物质的各种装置和方法。