公开(公告)号：US12161762B2

公开(公告)日：2024-12-10

申请号：US18203222

申请日：2023-05-30

Applicant: Korea University Research and Business Foundation

Inventor： Young-Keun Kim ,  Heemin Kang ,  Min-Jun Ko ,  Gunhyu Bae

IPC: C12N5/0786 ,  A61K9/51 ,  A61K47/69 ,  A61N2/00 ,  C12N13/00

Abstract: The present invention relates to a nanohelix-substrate complex for controlling adhesion and polarization of macrophages, a manufacturing method thereof, and a method of controlling adhesion and polarization of macrophages by using the nanohelix-substrate complex, and the method of controlling adhesion and polarization of macrophages may temporally and reversibly control adhesion and phenotypic polarization of macrophages in vivo and ex vivo by controlling application/non-application of a magnetic field to the nanohelix-substrate complex.

公开(公告)号：US12138352B2

公开(公告)日：2024-11-12

申请号：US17368883

申请日：2021-07-07

Applicant: Korea University Research and Business Foundation

Inventor： Young-Keun Kim ,  Heemin Kang ,  Min-Jun Ko ,  Gunhyu Bae

IPC: A61K9/51 ,  A61K47/69 ,  A61N2/00 ,  C12N5/0786 ,  C12N13/00

Abstract: The present invention relates to a nanohelix-substrate complex for controlling adhesion and polarization of macrophages, a manufacturing method thereof, and a method of controlling adhesion and polarization of macrophages by using the nanohelix-substrate complex, and the method of controlling adhesion and polarization of macrophages may temporally and reversibly control adhesion and phenotypic polarization of macrophages in vivo and ex vivo by controlling application/non-application of a magnetic field to the nanohelix-substrate complex.