- Patent Title: Nanohelix-substrate complex for controlling macrophage behavior, preparation method thereof, and method of controlling adhesion and polarization of macrophage by using the same
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Application No.: US18203222Application Date: 2023-05-30
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Publication No.: US12161762B2Publication Date: 2024-12-10
- Inventor: Young-Keun Kim , Heemin Kang , Min-Jun Ko , Gunhyu Bae
- Applicant: Korea University Research and Business Foundation
- Applicant Address: KR Seoul
- Assignee: Korea University Research and Business Foundation
- Current Assignee: Korea University Research and Business Foundation
- Current Assignee Address: KR Seoul
- Agency: NSIP Law
- Priority: KR10-2020-0131888 20201013
- Main IPC: C12N5/0786
- IPC: C12N5/0786 ; A61K9/51 ; A61K47/69 ; A61N2/00 ; C12N13/00
Abstract:
The present invention relates to a nanohelix-substrate complex for controlling adhesion and polarization of macrophages, a manufacturing method thereof, and a method of controlling adhesion and polarization of macrophages by using the nanohelix-substrate complex, and the method of controlling adhesion and polarization of macrophages may temporally and reversibly control adhesion and phenotypic polarization of macrophages in vivo and ex vivo by controlling application/non-application of a magnetic field to the nanohelix-substrate complex.
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