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公开(公告)号：US11981751B2
公开(公告)日：2024-05-14
申请号：US17246403
申请日：2021-04-30
Inventor： Heemin Kang , Young Keun Kim , Sunhong Min , Yoo Sang Jeon , Hyojun Choi
IPC: C07K5/08 , C07K5/09 , C12N5/0786
CPC classification number: C07K5/0817 , C12N5/0645
Abstract: Disclosed are a nanobarcode for controlling adhesion and polarization of macrophages and a method of controlling adhesion and polarization of macrophages by using nanobarcodes. The method of controlling adhesion and polarization of macrophages of the present invention may efficiently control adhesion and phenotypic polarization of macrophages in vivo or in vitro by tuning periodicity and sequences of ligand peptide (RGD) of a nanobarcode.
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Patent Agency Ranking
公开(公告)号：US12180505B2
公开(公告)日：2024-12-31
申请号：US17246376
申请日：2021-04-30
Inventor： Heemin Kang , Young Keun Kim , Sunhong Min , Yoo Sang Jeon , Hyojun Choi
IPC: C12N5/0775 , C07K5/09
Abstract: Disclosed are a nanobarcode for controlling adhesion and differentiation of stem cells and a method of controlling adhesion and differentiation of stem cells by using nanobarcodes. The method of controlling adhesion and differentiation of stem cells of the present invention may efficiently control adhesion and differentiation of stem cells in vivo or in vitro by tuning periodicity and sequences of a ligand peptide (RGD) of a nanobarcode.
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公开(公告)号：US12161762B2
公开(公告)日：2024-12-10
申请号：US18203222
申请日：2023-05-30
Inventor： Young-Keun Kim , Heemin Kang , Min-Jun Ko , Gunhyu Bae
IPC: C12N5/0786 , A61K9/51 , A61K47/69 , A61N2/00 , C12N13/00
Abstract: The present invention relates to a nanohelix-substrate complex for controlling adhesion and polarization of macrophages, a manufacturing method thereof, and a method of controlling adhesion and polarization of macrophages by using the nanohelix-substrate complex, and the method of controlling adhesion and polarization of macrophages may temporally and reversibly control adhesion and phenotypic polarization of macrophages in vivo and ex vivo by controlling application/non-application of a magnetic field to the nanohelix-substrate complex.
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公开(公告)号：US12297456B2
公开(公告)日：2025-05-13
申请号：US18199013
申请日：2023-05-18
Inventor： Heemin Kang , Young Keun Kim , Sunhong Min , Yoo Sang Jeon , Hyojun Choi
IPC: C12N5/0775 , C07K5/09
Abstract: Disclosed are a nanobarcode for controlling adhesion and differentiation of stem cells and a method of controlling adhesion and differentiation of stem cells by using nanobarcodes. The method of controlling adhesion and differentiation of stem cells of the present invention may efficiently control adhesion and differentiation of stem cells in vivo or in vitro by tuning periodicity and sequences of a ligand peptide (RGD) of a nanobarcode.
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公开(公告)号：US12138352B2
公开(公告)日：2024-11-12
申请号：US17368883
申请日：2021-07-07
Inventor： Young-Keun Kim , Heemin Kang , Min-Jun Ko , Gunhyu Bae
IPC: A61K9/51 , A61K47/69 , A61N2/00 , C12N5/0786 , C12N13/00
Abstract: The present invention relates to a nanohelix-substrate complex for controlling adhesion and polarization of macrophages, a manufacturing method thereof, and a method of controlling adhesion and polarization of macrophages by using the nanohelix-substrate complex, and the method of controlling adhesion and polarization of macrophages may temporally and reversibly control adhesion and phenotypic polarization of macrophages in vivo and ex vivo by controlling application/non-application of a magnetic field to the nanohelix-substrate complex.
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公开(公告)号：US20230241214A1
公开(公告)日：2023-08-03
申请号：US17827190
申请日：2022-05-27
Inventor： Heemin Kang , Yuri Kim , Gun-Hyu Bae , Sung-Gue Lee , Na-Yeon Kang
CPC classification number: A61K41/00 , A61B10/0045 , A61K47/16 , A61K9/5192
Abstract: Discloses is a technology of collecting a biological sample, delivering a substance into a living body, and regulating macrophage adhesion and polarization, by controlling a self-assembled complex and a nanosystem including the same by irradiation with light.
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