公开(公告)号：US20150374606A1

公开(公告)日：2015-12-31

申请号：US14315585

申请日：2014-06-26

Applicant: L'OREAL

Inventor： Jean-Marc SABATIER ,  Zhi Pan

IPC: A61K8/64 ,  A23L3/3544 ,  A61Q5/00 ,  C07K5/117 ,  A61Q19/00

CPC classification number: A61K8/64 ,  A23L3/3526 ,  A23L3/3544 ,  A23V2002/00 ,  A61K2800/10 ,  A61K2800/522 ,  A61Q5/00 ,  A61Q11/00 ,  A61Q19/00 ,  C07K5/0817 ,  C07K5/1024

Abstract: A tetrapeptide having antioxidant activity is provided. The tetrapeptide has a structure comprising, in amino acid sequence from N-terminus to C-terminus: tryptophan-X-tyrosine-X; wherein X is arginine, lysine, histidine or any positively-charged amino acid derivative such as 5-hydroxylysine, ornithine, 2,4-diamino-butyrate and 2,3-diamino-propionate. Each amino acid of the sequence or its Homo-amino acid derivative is independently of the D configuration (D-stereoisomer) or of the L configuration (L-stereoisomer), and the C-terminal comprises one selected from the group consisting of carboxyl (—COOH), and carboxamide (—CONH2). A composition stabilized to oxidation or having antioxidant activity and a method for attenuating effects of free radicals on a keratinous material are also provided.

Abstract translation: 提供了具有抗氧化活性的四肽。 四肽具有在N-末端至C末端的氨基酸序列中含有色氨酸-X-酪氨酸-X的结构; 其中X是精氨酸，赖氨酸，组氨酸或任何带正电荷的氨基酸衍生物如5-羟赖氨酸，鸟氨酸，2,4-二氨基丁酸酯和2,3-二氨基丙酸酯。 序列的每个氨基酸或其均聚氨基酸衍生物独立于D构型（D-立体异构体）或L构型（L-立体异构体），并且C-末端包括选自羧基（ -COOH）和羧酰胺（-CONH 2）。 还提供稳定化为氧化或具有抗氧化活性的组合物以及减少自由基对角质材料的影响的方法。