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公开(公告)号：US20230123569A1
公开(公告)日：2023-04-20
申请号：US18073120
申请日：2022-12-01
Applicant: LegoChem Biosciences, Inc.
Inventor： Dae Yon Lee , Sang Eun Chae , Eun Mi Jung , Eun Hye Yang , Yoon Jeong Choi , Chul-Woong Chung , Ju Hyun Shin , Yun Ki Kim , Hyun Jin Kwon , Jeong Hee Ryu , Eun Hye Ban , Yong Zu Kim , Yeong Soo Oh , Jeiwook Chae
IPC: C07D413/14 , C07D239/42 , C07D401/14 , C07D413/12 , C07D471/04 , C07D471/10 , C07D498/10 , C07D519/00
Abstract: The present invention relates to novel compounds as autotoxin inhibitors for treatment and prophylaxis of conditions or a disorder caused by autotaxin activation or increased concentration of lysophosphatidic acid, and also a pharmaceutical composition containing the same.
The novel compounds of the present invention are autotoxin inhibitors, and by inhibiting the production of lysophosphatidic acid, they are useful for treatment or prophylaxis of cardiovascular disorder, cancer, metabolic disorder, kidney disorder, liver disorder, inflammatory disorder, nervous system disorder, respiratory system disorder, fibrotic disease, ocular disorder, cholestatic and other forms of chronic pruritus, or acute or chronic organ transplant rejection.-
公开(公告)号：US11548883B2
公开(公告)日：2023-01-10
申请号：US16098748
申请日：2018-05-15
Applicant: LegoChem Biosciences, Inc.
Inventor： Dae Yon Lee , Sang Eun Chae , Eun Mi Jung , Eun Hye Yang , Yoon Jeong Choi , Chul-Woong Chung , Ju Hyun Shin , Yun Ki Kim , Hyun Jin Kwon , Jeong Hee Ryu , Eun Hye Ban , Yong Zu Kim , Yeong Soo Oh , Jeiwook Chae
IPC: C07D413/14 , C07D239/42 , C07D401/14 , C07D413/12 , C07D471/04 , C07D471/10 , C07D498/10 , C07D519/00
Abstract: The present invention relates to novel compounds as autotoxin inhibitors for treatment and prophylaxis of conditions or a disorder caused by autotaxin activation or increased concentration of lysophosphatidic acid, and also a pharmaceutical composition containing the same.
The novel compounds of the present invention are autotoxin inhibitors, and by inhibiting the production of lysophosphatidic acid, they are useful for treatment or prophylaxis of cardiovascular disorder, cancer, metabolic disorder, kidney disorder, liver disorder, inflammatory disorder, nervous system disorder, respiratory system disorder, fibrotic disease, ocular disorder, cholestatic and other forms of chronic pruritus, or acute or chronic organ transplant rejection.-
公开(公告)号：US20170088614A1
公开(公告)日：2017-03-30
申请号：US15276209
申请日：2016-09-26
Applicant: LegoChem Biosciences, Inc.
Inventor： Yong Zu Kim , Yun Hee Park , Jeong Hee Ryu , Ho Young Song , Jeiwook Chae , Chul-Woong Chung , Ji Eun Jung , Hyo Jung Choi
CPC classification number: C07K16/2803 , A61K31/351 , A61K47/6803 , A61K47/6831 , A61K47/6849 , A61K47/6889 , A61K2039/505 , C07D301/10 , C07K2317/24 , C07K2317/73 , C07K2317/92 , C07K2317/94 , Y02A50/475
Abstract: In some aspects, the invention relates to an antibody-drug conjugate, comprising an anti-CD19 antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self-immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.
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公开(公告)号：US10383949B2
公开(公告)日：2019-08-20
申请号：US16005245
申请日：2018-06-11
Applicant: LegoChem Biosciences, Inc.
Inventor： Yong Zu Kim , Tae Kyo Park , Sung Ho Woo , Sun Young Kim , Jong Un Cho , Doo Hwan Jung , Ji Young Min , Hyang Sook Lee , Yun Hee Park , Jeong Hee Ryu , Kyu Man Oh , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung , Jeon Yang
IPC: A61K47/68 , C07D249/04 , C07K19/00 , C07K16/32 , A61K47/69 , C07D487/04 , C07D519/00 , A61K47/54 , A61K47/50 , A61K39/00
Abstract: Provided are compounds comprising a self-immolative group, and the compounds comprising a self-immolative group according to the present invention may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.
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公开(公告)号：US20170095576A1
公开(公告)日：2017-04-06
申请号：US14898932
申请日：2015-05-27
Applicant: LEGOCHEM BIOSCIENCES, INC.
Inventor： Yong Zu Kim , Tae Kyo Park , Sung Ho Woo , Sun Young Kim , Jong Un Cho , Doo Hwan Jung , Ji Young Min , Hyang Sook Lee , Yun Hee Park , Jeong Hee Ryu , Kyu Man Oh , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung , Jeon Yang
CPC classification number: A61K47/6871 , A61K47/549 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6855 , A61K47/6889 , A61K47/69 , A61K2039/505 , C07D249/04 , C07D487/04 , C07D519/00 , C07K16/32 , C07K19/00 , C07K2317/24
Abstract: Provided are methods of use of compounds comprising a self-immolative group, which compounds may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20200172542A1
公开(公告)日：2020-06-04
申请号：US16783893
申请日：2020-02-06
Applicant: LegoChem Biosciences, Inc.
Inventor： Dae Yon Lee , Sang Eun Chae , Eun Mi Jung , Eun Hye Yang , Yoon Jeong Choi , Chul-Woong Chung , Ju Hyun Shin , Yun Ki Kim , Hyun Jin Kwon , Jeong Hee Ryu , Eun Hye Ban , Yong Zu Kim , Yeong Soo Oh , Jeiwook Chae
IPC: C07D471/04 , C07D498/10 , C07D519/00 , C07D471/10 , C07D413/14 , C07D413/12 , C07D403/14 , C07D401/14 , C07D513/04
Abstract: The present invention relates to novel compounds as autotoxin inhibitors for treatment and prophylaxis of conditions or a disorder caused by autotaxin activation or increased concentration of lysophosphatidic acid, and also a pharmaceutical composition containing the same.The novel compounds of the present invention are autotoxin inhibitors, and by inhibiting the production of lysophosphatidic acid, they are useful for treatment or prophylaxis of cardiovascular disorder, cancer, metabolic disorder, kidney disorder, liver disorder, inflammatory disorder, nervous system disorder, respiratory system disorder, fibrotic disease, ocular disorder, cholestatic and other forms of chronic pruritus, or acute or chronic organ transplant rejection.
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公开(公告)号：US20180353611A1
公开(公告)日：2018-12-13
申请号：US16005245
申请日：2018-06-11
Applicant: LegoChem Biosciences, Inc.
Inventor： Yong Zu Kim , Tae Kyo Park , Sung Ho Woo , Sun Young Kim , Jung Un Cho , Doo Hwan Jung , Ji Young Min , Hyang Sook Lee , Yun Hee Park , Jeong Hee Ryu , Kyu Man Oh , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung , Jeon Yang
IPC: A61K47/68 , C07K19/00 , C07K16/32 , C07D519/00 , C07D487/04 , C07D249/04 , A61K47/54 , A61K47/69 , A61K39/00
CPC classification number: A61K47/6871 , A61K47/50 , A61K47/549 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6855 , A61K47/6889 , A61K47/69 , A61K2039/505 , C07D249/04 , C07D487/04 , C07D519/00 , C07K16/32 , C07K19/00 , C07K2317/24 , C07K2317/94
Abstract: Provided are compounds comprising a self-immolative group, and the compounds comprising a self-immolative group according to the present invention may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.
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公开(公告)号：US09919057B2
公开(公告)日：2018-03-20
申请号：US14865778
申请日：2015-09-25
Applicant: LegoChem Biosciences, Inc.
Inventor： Yong Zu Kim , Tae Kyo Park , Sung Ho Woo , Sun Young Kim , Jong Un Cho , Doo Hwan Jung , Jeon Yang , Ji Young Min , Hyang Sook Lee , Yun Hee Park , Jeong Hee Ryu , Kyu Man Oh , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung
IPC: C07D309/10 , A61K47/48 , C07D249/04 , C07K19/00
CPC classification number: A61K47/6871 , A61K47/549 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6855 , A61K47/6889 , A61K47/69 , A61K2039/505 , C07D249/04 , C07D487/04 , C07D519/00 , C07K16/32 , C07K19/00 , C07K2317/24
Abstract: Provided are compounds comprising a self-immolative group, and the compounds comprising a self-immolative group according to the present invention may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.
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公开(公告)号：US20160184451A1
公开(公告)日：2016-06-30
申请号：US14865778
申请日：2015-09-25
Applicant: LegoChem Biosciences, Inc.
Inventor： Yong Zu Kim , Tae Kyo Park , Sung Ho Woo , Sun Young Kim , Jong Un Cho , Doo Hwan Jung , Jeon Yang , Ji Young Min , Hyang Sook Lee , Yun Hee Park , Jeong Hee Ryu , Kyu Man Oh , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung
IPC: A61K47/48
CPC classification number: A61K47/6871 , A61K47/549 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6855 , A61K47/6889 , A61K47/69 , A61K2039/505 , C07D249/04 , C07D487/04 , C07D519/00 , C07K16/32 , C07K19/00 , C07K2317/24
Abstract: Provided are compounds comprising a self-immolative group, and the compounds comprising a self-immolative group according to the present invention may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.
Abstract translation: 本发明提供的是包含自褪色基团的化合物，并且包含本发明的自褪色组的化合物可以包括具有底物特异性的蛋白质（例如寡肽，多肽，抗体等） 具有特定功能或活性的靶和活性剂（例如药物，毒素，配体，检测探针等）。
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公开(公告)号：US10980890B2
公开(公告)日：2021-04-20
申请号：US16545869
申请日：2019-08-20
Applicant: LegoChem Biosciences, Inc.
Inventor： Yong Zu Kim , Tae Kyo Park , Sung Ho Woo , Sun Young Kim , Jong Un Cho , Doo Hwan Jung , Ji Young Min , Hyang Sook Lee , Yun Hee Park , Jeong Hee Ryu , Kyu Man Oh , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung , Jeon Yang
IPC: A61K47/54 , C07K19/00 , C07D487/04 , C07D519/00 , A61K47/68 , A61K47/50 , C07D249/04 , C07K16/32 , A61K47/69 , A61K39/00
Abstract: Provided herein are compounds comprising a self-immolative group, and the compounds comprising a self-immolative group according to the present invention may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.
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