公开(公告)号：US20180327738A1

公开(公告)日：2018-11-15

申请号：US15777182

申请日：2016-11-18

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Namritha RAVINDER ,  Robert Jason POTTER ,  Jason CARTE

IPC: C12N15/10 ,  C12N9/22

CPC classification number: C12N15/1003 ,  C07K2319/80 ,  C07K2319/81 ,  C12N9/22

Abstract: The present disclosure generally relates to compositions and methods for genetic modification of cells. In particular, the disclosure relates to stabilized reagents for genome alteration (e.g., site specific nucleases), as well as stabilized reagents for non-genetic code altering modification (e.g., DNA methylation). Stabilization methods include storage of reagents at suitable temperatures, conversion to dry forms, and chemical modifications.