公开(公告)号：US20180195089A1

公开(公告)日：2018-07-12

申请号：US15842664

申请日：2017-12-14

Applicant: LIFE TECHNOLOGIES CORPORATION ,  THERMO FISHER SCIENTIFIC GENEART GMBH

Inventor： Namritha RAVINDER ,  Korbinian HEIL ,  Yizhu GUO ,  Xiquan LIANG ,  Robert POTTER ,  Sanjay KUMAR

IPC: C12N15/90 ,  C12N15/10 ,  C12Q1/686 ,  C12P19/34 ,  C12N15/11

CPC classification number: C12N15/907 ,  C12N15/102 ,  C12N15/11 ,  C12N2310/3519 ,  C12P19/34 ,  C12Q1/686 ,  C12Q2525/143

Abstract: The present disclosure generally relates to compositions and methods for the genetic modification of cells. In particular, the disclosure relates to CRISPR reagents and the use of such reagents.

公开(公告)号：US20180327738A1

公开(公告)日：2018-11-15

申请号：US15777182

申请日：2016-11-18

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Namritha RAVINDER ,  Robert Jason POTTER ,  Jason CARTE

IPC: C12N15/10 ,  C12N9/22

CPC classification number: C12N15/1003 ,  C07K2319/80 ,  C07K2319/81 ,  C12N9/22

Abstract: The present disclosure generally relates to compositions and methods for genetic modification of cells. In particular, the disclosure relates to stabilized reagents for genome alteration (e.g., site specific nucleases), as well as stabilized reagents for non-genetic code altering modification (e.g., DNA methylation). Stabilization methods include storage of reagents at suitable temperatures, conversion to dry forms, and chemical modifications.

公开(公告)号：US20220033858A1

公开(公告)日：2022-02-03

申请号：US17327002

申请日：2021-05-21

Applicant: LIFE TECHNOLOGIES CORPORATION ,  THERMO FISHER SCIENTIFIC GENEART GMBH

Inventor： Namritha RAVINDER ,  Korbinian HEIL ,  Yizhu GUO ,  Xiquan LIANG ,  Robert POTTER ,  Sanjay KUMAR

IPC: C12N15/90 ,  C12Q1/686 ,  C12N15/10 ,  C12N15/11 ,  C12P19/34

Abstract: The present disclosure generally relates to compositions and methods for the genetic modification of cells. In particular, the disclosure relates to CRISPR reagents and the use of such reagents.

公开(公告)号：US20200080077A1

公开(公告)日：2020-03-12

申请号：US16536983

申请日：2019-08-09

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Xiquan LIANG ,  Robert POTTER ,  Namritha RAVINDER ,  Shantanu KUMAR

IPC: C12N15/10 ,  C12N15/113 ,  C12N15/90

Abstract: The present disclosure generally relates to compositions and methods for improving the efficiency of homologous recombination. In particular, the disclosure relates to reagents and the use of such reagents.

公开(公告)号：US20180023075A1

公开(公告)日：2018-01-25

申请号：US15605586

申请日：2017-05-25

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Xiquan LIANG ,  Robert POTTER ,  Namritha RAVINDER ,  Shantanu KUMAR

IPC: C12N15/10 ,  C12N15/113

CPC classification number: C12N15/1082 ,  A01K2217/07 ,  C12N15/102 ,  C12N15/1024 ,  C12N15/1034 ,  C12N15/113 ,  C12N15/907 ,  C12N2310/152 ,  C12N2310/153 ,  C12N2310/20 ,  C12N2310/533 ,  C12Q2600/156

Abstract: The present disclosure generally relates to compositions and methods for improving the efficiency of homologous recombination. In particular, the disclosure relates to reagents and the use of such reagents.