公开(公告)号：US20190300936A1

公开(公告)日：2019-10-03

申请号：US16382294

申请日：2019-04-12

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Jacob K. FREUDENTHAL ,  Geoffrey DAHLHOFF ,  Kevin MAHER ,  Ming Song CHEN ,  Gary LIM ,  Ronald DANEHY ,  David FORTESCUE ,  Ming SHEN ,  Woon Liang Soh ,  Francis T. CHENG ,  Ruoyun WU ,  Thiam Chye LEE ,  Gary A. CHAPPELL ,  Chee Kiong LIM ,  Jeff DERE ,  Ted E. STRAUB ,  Jorge FONSECA ,  Kuan Moon BOO ,  Soo Yong LAU

IPC: C12Q1/686 ,  B01L3/00 ,  B01L7/00

Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lends can be a bi-convex lens.

公开(公告)号：US20230417676A1

公开(公告)日：2023-12-28

申请号：US18308177

申请日：2023-04-27

Applicant: LIFE TECHNOLOGIES HOLDINGS PTE LIMITED ,  LIFE TECHNOLOGIES CORPORATION

Inventor： Ming Song CHEN ,  Chee Woei CHONG ,  Wuh Ken LOH ,  WERN YUH FOO ,  Kuan Moon BOO ,  Norbert LECLERC ,  Kristina UHLENDORF ,  Reiner KOELLNER ,  Torsten FUCHS ,  Stefan Breitfelder

IPC: G01N21/64

CPC classification number: G01N21/6452 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6478

Abstract: A biological analysis system can include an excitation module and an emission module. The excitation module can include a collimator element for receiving excitation light from the excitation light source and transmitting collimated excitation light in a first direction, and a plurality of excitation mirrors arrayed along the excitation light path, each excitation mirror disposed at an acute angle relative to the first direction and configured to reflect collimated excitation light along a second direction. The emission module can be positioned to receive excitation light transmitted along the second direction and can include a sample block comprising a plurality of sample receptacles positioned to receive a beam of collimated excitation light, and a plurality of photodetectors configured to receive emission light transmitted from a respective sample receptacle in a direction transverse to the second direction of the excitation light path.

公开(公告)号：US20220205915A1

公开(公告)日：2022-06-30

申请号：US17572926

申请日：2022-01-11

Applicant: LIFE TECHNOLOGIES HOLDINGS PTE LIMITED ,  LIFE TECHNOLOGIES CORPORATION

Inventor： Ming Song CHEN ,  Chee Woei CHONG ,  Wuh Ken LOH ,  WERN YUH FOO ,  Kuan Moon BOO ,  Norbert LECLERC ,  Kristina UHLENDORF ,  Reiner KOELLNER ,  Torsten FUCHS ,  Stefan BREITFELDER

IPC: G01N21/64

Abstract: A biological analysis system can include an excitation module and an emission module. The excitation module can include a collimator element for receiving excitation light from the excitation light source and transmitting collimated excitation light in a first direction, and a plurality of excitation mirrors arrayed along the excitation light path, each excitation mirror disposed at an acute angle relative to the first direction and configured to reflect collimated excitation light along a second direction. The emission module can be positioned to receive excitation light transmitted along the second direction and can include a sample block comprising a plurality of sample receptacles positioned to receive a beam of collimated excitation light, and a plurality of photodetectors configured to receive emission light transmitted from a respective sample receptacle in a direction transverse to the second direction of the excitation light path.