公开(公告)号：US20240159677A1

公开(公告)日：2024-05-16

申请号：US18388470

申请日：2023-11-09

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Kevin MAHER ,  Mingsong CHEN ,  Jacob K. FREUDENTHAL ,  Kuan Moon BOO ,  Soo Yong LAU ,  David FORTESCUE ,  Ming SHEN ,  Woon Liang Terence SOH

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2201/062

Abstract: An instrument for processing and/or measuring a biological process comprises a plurality of filter assemblies configured to be interchangeably located along at least one of the optical paths. The plurality of filter components includes a first filter assembly characterized by a first optical power and a first filter having a first filter function, the first filter function characterized by at least one of a first low-pass wavelength or a first high-pass wavelength. The second filter assembly is characterized by a second optical power and a second filter having a second filter function, the second filter function comprising at least one of a second low-pass wavelength that is different than the first low-pass wavelength or a second high-pass wavelength that is different than the first high-pass wavelength.

公开(公告)号：US20170307529A1

公开(公告)日：2017-10-26

申请号：US15643626

申请日：2017-07-07

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Kevin MAHER ,  Mingsong CHEN ,  Jacob K. FREUDENTHAL ,  Kuan Moon BOO ,  Soo Yong LAU ,  David FORTESCUE ,  Ming SHEN ,  Woon Liang Terence SOH

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2201/062

Abstract: An instrument for processing and/or measuring a biological process contains an excitation source, a sample holder, an optical sensor, an excitation optical system, and an emission optical system. The sample holder is configured to receive a plurality of biological samples. The optical sensor is configured to receive an emission from the biological samples. The excitation optical system is disposed along an excitation optical path and is configured to direct the electromagnetic radiation from the excitation source to the biological samples. The emission optical system is disposed along an emission optical path and is configured to direct electromagnetic emissions from the biological samples to the optical sensor. The instrument further contains a plurality of filter assemblies configured to be interchangeably located along at least one of the optical paths. The plurality of filter components includes a first filter assembly characterized by a first optical power and a first filter having a first filter function, the first filter function characterized by at least one of a first low-pass wavelength or a first high-pass wavelength. The second filter assembly is characterized by a second optical power and a second filter having a second filter function, the second filter function comprising at least one of a second low-pass wavelength that is different than the first low-pass wavelength or a second high-pass wavelength that is different than the first high-pass wavelength.

公开(公告)号：US20220412890A1

公开(公告)日：2022-12-29

申请号：US17825222

申请日：2022-05-26

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Kevin MAHER ,  Mingsong CHEN ,  Jacob K. FREUDENTHAL ,  Kuan Moon BOO ,  Soo Yong LAU ,  David FORTESCUE ,  Ming SHEN ,  Woon Liang Terence SOH

IPC: G01N21/64

Abstract: An instrument for processing and/or measuring a biological process comprises a plurality of filter assemblies configured to be interchangeably located along at least one of the optical paths. The plurality of filter components includes a first filter assembly characterized by a first optical power and a first filter having a first filter function, the first filter function characterized by at least one of a first low-pass wavelength or a first high-pass wavelength. The second filter assembly is characterized by a second optical power and a second filter having a second filter function, the second filter function comprising at least one of a second low-pass wavelength that is different than the first low-pass wavelength or a second high-pass wavelength that is different than the first high-pass wavelength.

公开(公告)号：US20190300936A1

公开(公告)日：2019-10-03

申请号：US16382294

申请日：2019-04-12

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Jacob K. FREUDENTHAL ,  Geoffrey DAHLHOFF ,  Kevin MAHER ,  Ming Song CHEN ,  Gary LIM ,  Ronald DANEHY ,  David FORTESCUE ,  Ming SHEN ,  Woon Liang Soh ,  Francis T. CHENG ,  Ruoyun WU ,  Thiam Chye LEE ,  Gary A. CHAPPELL ,  Chee Kiong LIM ,  Jeff DERE ,  Ted E. STRAUB ,  Jorge FONSECA ,  Kuan Moon BOO ,  Soo Yong LAU

IPC: C12Q1/686 ,  B01L3/00 ,  B01L7/00

Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lends can be a bi-convex lens.

公开(公告)号：US20160011115A1

公开(公告)日：2016-01-14

申请号：US14766725

申请日：2014-02-24

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Mingsong CHEN ,  Mauro AGUANNO ,  Kuan Moon BOO ,  Woon Liang Terence SOH ,  Jacob K. FREUDENTHAL ,  Jeffrey A. MARKS

IPC: G01N21/64 ,  G01N21/03

Abstract: An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.

Abstract translation: 用于处理和/或测量生物过程的仪器包括样品处理系统，激发源，激发光学系统，光学传感器和发射光学系统。 样品处理系统被配置为保持第一样品保持器和第二样品保持器，其中样品池的数量对于每个样品保持器是不同的，或者第一样品池的特征尺寸与第二样品保持器的特征尺寸不同。 仪器还包括激发源温度控制器，其包括耦合到激发源的温度传感器。 温度控制器被配置为当第一样本保持器被仪器保持时产生第一目标温度，并且当第二样本保持器被仪器保持时产生第二目标温度。