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    Acoustically settled liquid-liquid sample purification system
    2.
    发明授权
    Acoustically settled liquid-liquid sample purification system 有权

    公开(公告)号：US11173417B2

    公开(公告)日：2021-11-16

    申请号：US16819951

    申请日：2020-03-16

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Scott P. Collins ,  Christopher D. Brau ,  Nephi D. Jones

    IPC: B01D11/04 ,  B01F11/00 ,  B01F13/10 ,  G01N1/34 ,  G01N1/40

    Abstract: A sample purification system includes a container assembly bounding a sample purification compartment and having an upper end and an opposing lower end, the sample purification compartment comprising mixing zones and settling zones. A plurality of shielding elements are positioned within the sample purification compartment so as to at least partially separate adjacent mixing zones and settling zones or separate adjacent mixing zones, the mixing zones being in fluid communication with the settling zones. A mixing element is disposed within each mixing zone. An acoustic wave settler is aligned with a portion of the container assembly, the acoustic wave settler being configured to emit an acoustic wave through the portion of the container assembly and a mixture disposed therein, the acoustic wave coalescing fluid phase droplets disposed in the mixture to increase the buoyancy or density of the fluid phase droplets.

    Continuous Sample Purification Systems and Methods
    4.
    发明申请
    Continuous Sample Purification Systems and Methods 审中-公开

    公开(公告)号：US20190001237A1

    公开(公告)日：2019-01-03

    申请号：US16067509

    申请日：2016-12-21

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Scott P. Collins ,  Federico Carlos Rodriguez Peralta ,  Nephi D. Jones ,  Christopher D. Brau

    IPC: B01D11/04 ,  B01D15/36 ,  B01D15/38

    Abstract: Sample purification systems include a particle extraction assembly having a mixing compartment and a settling compartment. A biological sample is mixed with two liquid phases formulated to effectuate transfer of a biological molecule into a first phase and particulate contaminants into a second phase. The first phase includes a solubilizing salt, the second phase includes an organic molecule, and the mixture can have little or no monoatomic salt or dextran. The molecule-containing first phase can be optionally concentrated without also concentrating the particulate contaminants and introduced into a multi-stage liquid-liquid extractor, by which the biological molecule or molecular contaminants are extracted from the first phase into a third phase, thereby purifying the molecule away from contaminants. The extracted sample can be further purified through a series of processing steps. The system can be run in continuously mode to maintain sterility of the sample.

    Continuous Sample Purification Systems and Methods
    5.
    发明申请
    Continuous Sample Purification Systems and Methods 有权

    公开(公告)号：US20220339554A1

    公开(公告)日：2022-10-27

    申请号：US17861638

    申请日：2022-07-11

    Applicant: Life Technologies Corporation

    Inventor： Scott P. Collins ,  Federico Carlos Rodriguez Peralta ,  Nephi D. Jones ,  Christopher D. Brau

    IPC: B01D11/04 ,  B01D11/02 ,  B01D15/36 ,  B01D15/38

    Abstract: Sample purification systems include a particle extraction assembly having a mixing compartment and a settling compartment. A biological sample is mixed with two liquid phases formulated to effectuate transfer of a biological molecule into a first phase and particulate contaminants into a second phase. The first phase includes a solubilizing salt, the second phase includes an organic molecule, and the mixture can have little or no monoatomic salt or dextran. The molecule-containing first phase can be optionally concentrated without also concentrating the particulate contaminants and introduced into a multi-stage liquid-liquid extractor, by which the biological molecule or molecular contaminants are extracted from the first phase into a third phase, thereby purifying the molecule away from contaminants. The extracted sample can be further purified through a series of processing steps. The system can be run in continuously mode to maintain sterility of the sample.

    Continuous sample purification systems and methods
    6.
    发明授权
    Continuous sample purification systems and methods 有权

    公开(公告)号：US11426679B2

    公开(公告)日：2022-08-30

    申请号：US16067509

    申请日：2016-12-21

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Scott P. Collins ,  Federico Carlos Rodriguez Peralta ,  Nephi D. Jones ,  Christopher D. Brau

    IPC: B01D11/04 ,  B01D15/36 ,  B01D15/38 ,  B01D11/02

    Abstract: Sample purification systems include a particle extraction assembly having a mixing compartment and a settling compartment. A biological sample is mixed with two liquid phases formulated to effectuate transfer of a biological molecule into a first phase and particulate contaminants into a second phase. The first phase includes a solubilizing salt, the second phase includes an organic molecule, and the mixture can have little or no monoatomic salt or dextran. The molecule-containing first phase can be optionally concentrated without also concentrating the particulate contaminants and introduced into a multi-stage liquid-liquid extractor, by which the biological molecule or molecular contaminants are extracted from the first phase into a third phase, thereby purifying the molecule away from contaminants. The extracted sample can be further purified through a series of processing steps. The system can be run in continuously mode to maintain sterility of the sample.

    ACOUSTICALLY SETTLED LIQUID-LIQUID SAMPLE PURIFICATION SYSTEM
    7.
    发明申请
    ACOUSTICALLY SETTLED LIQUID-LIQUID SAMPLE PURIFICATION SYSTEM 审中-公开

    公开(公告)号：US20170354901A1

    公开(公告)日：2017-12-14

    申请号：US15521227

    申请日：2015-10-23

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Scott P. Collins ,  Christopher D Brau ,  Nephi D. Jones

    IPC: B01D11/04 ,  G01N1/34

    CPC classification number: B01D11/0423 ,  B01D11/043 ,  B01D11/0449 ,  B01D11/0457 ,  G01N1/34 ,  G01N2001/4061

    Abstract: A sample purification system includes a container assembly bounding a sample purification compartment and having an upper end and an opposing lower end, the sample purification compartment comprising mixing zones and settling zones. A plurality of shielding elements are positioned within the sample purification compartment so as to at least partially separate adjacent mixing zones and settling zones or separate adjacent mixing zones, the mixing zones being in fluid communication with the settling zones. A mixing element is disposed within each mixing zone. An acoustic wave settler is aligned with a portion of the container assembly, the acoustic wave settler being configured to emit an acoustic wave through the portion of the container assembly and a mixture disposed therein, the acoustic wave coalescing fluid phase droplets disposed in the mixture to increase the buoyancy or density of the fluid phase droplets.

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