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公开(公告)号：US08691747B2
公开(公告)日：2014-04-08
申请号：US13879635
申请日：2011-10-25
IPC分类号： A61K31/00
CPC分类号： A61K39/3955 , C12N9/14 , C12N15/1137 , C12N2310/14 , C12Y306/01 , G01N33/53
摘要： A method of treating autoimmune and inflammatory diseases or conditions in a mammal, such as a human, which comprises the administration of a inhibitor of the bromodomain-containing protein: ATAD2.
摘要翻译： 治疗哺乳动物（例如人）中的自身免疫性和炎性疾病或病症的方法，其包括施用含有溴结构域的蛋白质的抑制剂：ATAD2。
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公开(公告)号：US20130224204A1
公开(公告)日：2013-08-29
申请号：US13879635
申请日：2011-10-25
IPC分类号： A61K39/395 , G01N33/53
CPC分类号： A61K39/3955 , C12N9/14 , C12N15/1137 , C12N2310/14 , C12Y306/01 , G01N33/53
摘要： A method of treating autoimmune and inflammatory diseases or conditions in a mammal, such as a human, which comprises the administration of a inhibitor of the bromodomain-containing protein: ATAD2.
摘要翻译： 治疗哺乳动物（例如人）中的自身免疫性和炎性疾病或病症的方法，其包括施用含有溴结构域的蛋白质的抑制剂：ATAD2。
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公开(公告)号：US20120202875A1
公开(公告)日：2012-08-09
申请号：US13500408
申请日：2010-10-26
IPC分类号： A61K31/713 , C40B30/06 , C07H21/02 , A61P37/00 , A61P29/00
CPC分类号： G01N33/5008 , C12N15/1137 , C12N2310/14
摘要： The present invention relates to methods for treatment or prevention of autoimmune and inflammatory diseases and conditions by inhibiting or modifying histone demethylation. In a further aspect the invention relates to a method for identifying agents useful in said methods of treatment. The invention particularly describes the role of certain histone demethylase enzymes in these diseases and conditions and their use as therapeutic and screening targets.
摘要翻译： 本发明涉及通过抑制或修饰组蛋白去甲基化来治疗或预防自身免疫性和炎性疾病和病症的方法。 在另一方面，本发明涉及用于鉴定在所述治疗方法中有用的药剂的方法。 本发明特别描述了某些组蛋白脱甲基酶在这些疾病和病症中的作用及其作为治疗和筛选靶标的用途。
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公开(公告)号：US08697725B2
公开(公告)日：2014-04-15
申请号：US13501159
申请日：2010-11-03
申请人： Emmanuel Hubert Demont , Neil Stuart Garton , Romain Luc Marie Gosmini , Thomas George Christopher Hayhow , Jonathan Seal , David Matthew Wilson , Michael David Woodrow
发明人： Emmanuel Hubert Demont , Neil Stuart Garton , Romain Luc Marie Gosmini , Thomas George Christopher Hayhow , Jonathan Seal , David Matthew Wilson , Michael David Woodrow
IPC分类号： A61K31/04 , C07D215/38
CPC分类号： C07D215/42
摘要： Tetrahydroquinoline compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.
摘要翻译： 式（I）的四氢喹啉化合物及其盐，含有这些化合物的药物组合物及其在治疗中的用途。
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公开(公告)号：US08207331B2
公开(公告)日：2012-06-26
申请号：US12707147
申请日：2010-02-17
申请人： Mark James Bamford , David Kenneth Dean , Sanjeet Singh Sehmi , David Matthew Wilson , Jason Witherington
发明人： Mark James Bamford , David Kenneth Dean , Sanjeet Singh Sehmi , David Matthew Wilson , Jason Witherington
IPC分类号： C07D223/16
CPC分类号： C07D223/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/04
摘要： The present invention relates to novel benzazepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
摘要翻译： 本发明涉及具有药理学活性的新的苯并氮杂衍生物，其制备方法，含有它们的组合物及其在治疗神经和精神疾病中的用途。
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![Pyrazolo [3,4-D]azepine derivatives as histamine H3 antagonists](/abs-image/US/2011/02/15/US07888347B2/abs.jpg.150x150.jpg)
6.发明授权公开(公告)号：US07888347B2
公开(公告)日：2011-02-15
申请号：US11994689
申请日：2006-07-04
IPC分类号： A61P25/28 , A61K31/55 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to novel pyrazole derivatives of formula I having pharmacological activity as H3 antagonists processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
摘要翻译： 本发明涉及具有药理学活性的式I的吡唑衍生物，其具有作为其制备的H3拮抗剂的方法，含有它们的组合物及其在治疗神经和精神疾病中的用途。
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公开(公告)号：US07696193B2
公开(公告)日：2010-04-13
申请号：US10539385
申请日：2003-12-18
IPC分类号： A61P7/00 , A61K31/55 , C07D223/16
CPC分类号： C07D223/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/04
摘要： The present invention relates to benzazepine derivatives of formula (I) wherein: R1 represents —C3-7 cycloalkyl optionally substituted by C1-3 alkyl; having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
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公开(公告)号：US20080207638A1
公开(公告)日：2008-08-28
申请号：US11995927
申请日：2006-07-17
申请人： Rachael Ann Ancliff , Mark James Bamford , Simon Teanby Hodgson , Christopher Allan Parr , Panayiotis Alexandrou Procopiou , David Matthew Wilson , Michael Woodrow
发明人： Rachael Ann Ancliff , Mark James Bamford , Simon Teanby Hodgson , Christopher Allan Parr , Panayiotis Alexandrou Procopiou , David Matthew Wilson , Michael Woodrow
IPC分类号： A61K31/4965 , C07D241/02 , A61P11/00
CPC分类号： C07D403/12
摘要： The present invention relates to compounds of formula (I), and salts thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders, such as allergic rhinitis.
摘要翻译： 本发明涉及式（I）化合物及其盐，其制备方法，含有它们的组合物及其在治疗各种疾病如过敏性鼻炎中的用途。
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公开(公告)号：US07199137B2
公开(公告)日：2007-04-03
申请号：US10380891
申请日：2001-09-19
IPC分类号： A61K31/4439 , C07D401/04
CPC分类号： C07D401/04 , A61K49/0021 , C07D401/14 , C07D405/14
摘要： Novel compounds (I) and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy wherein Ar is a group of formula a) or b).
摘要翻译： 新型化合物（I）及其作为药物特别用作治疗神经创伤性疾病，癌症，慢性神经变性，疼痛，偏头痛和心脏肥大的Raf激酶抑制剂的用途，其中Ar是式a）或b）的基团。
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10.发明授权7-(1H-pyrazol-4-yl)-1,6-naphthyridine compounds as Syk inhibitors 失效7-（1H-吡唑-4-基）-1,6-萘啶化合物作为Syk抑制剂公开(公告)号：US08633319B2
公开(公告)日：2014-01-21
申请号：US13642338
申请日：2011-04-27
申请人： Francis Louis Atkinson , Michael David Barker , Clement Douault , Neil Stuart Garton , John Liddle , Vipulkumar Kantibhai Patel , Alexander George Steven Preston , David Matthew Wilson
发明人： Francis Louis Atkinson , Michael David Barker , Clement Douault , Neil Stuart Garton , John Liddle , Vipulkumar Kantibhai Patel , Alexander George Steven Preston , David Matthew Wilson
IPC分类号： C07D471/04 , A61K31/4375
CPC分类号： C07D471/04
摘要： The present invention relates to a compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (Syk) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast and/or basophil cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory disease and/or allergic disorders, and in cancer therapy, specifically heme malignancies, chronic spontaneous urticaria and autoimmune conditions.
摘要翻译： 本发明涉及式（I）化合物或其盐; 其是脾脏酪氨酸激酶（Syk）的抑制剂，因此潜在地用于治疗由桅杆和/或嗜碱性粒细胞，巨噬细胞和B细胞的不适当活化引起的疾病以及相关的炎症反应和组织损伤，例如炎性疾病和 /或过敏性疾病，以及癌症治疗，特别是血红素恶性肿瘤，慢性自发性荨麻疹和自身免疫性疾病。
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