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公开(公告)号：US20080207638A1
公开(公告)日：2008-08-28
申请号：US11995927
申请日：2006-07-17
申请人： Rachael Ann Ancliff , Mark James Bamford , Simon Teanby Hodgson , Christopher Allan Parr , Panayiotis Alexandrou Procopiou , David Matthew Wilson , Michael Woodrow
发明人： Rachael Ann Ancliff , Mark James Bamford , Simon Teanby Hodgson , Christopher Allan Parr , Panayiotis Alexandrou Procopiou , David Matthew Wilson , Michael Woodrow
IPC分类号： A61K31/4965 , C07D241/02 , A61P11/00
CPC分类号： C07D403/12
摘要： The present invention relates to compounds of formula (I), and salts thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders, such as allergic rhinitis.
摘要翻译： 本发明涉及式（I）化合物及其盐，其制备方法，含有它们的组合物及其在治疗各种疾病如过敏性鼻炎中的用途。
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公开(公告)号：US20110281909A1
公开(公告)日：2011-11-17
申请号：US12673027
申请日：2008-08-13
申请人： Paul Martin Gore , Ashley Paul Hancock , Simon Teanby Hodgson , Panayiotis Alexandrou Procopiou , Sadie Vile
发明人： Paul Martin Gore , Ashley Paul Hancock , Simon Teanby Hodgson , Panayiotis Alexandrou Procopiou , Sadie Vile
IPC分类号： A61K31/4709 , A61P37/08 , C07D215/26
CPC分类号： C07D409/14 , C07D401/12
摘要： The present invention relates to compounds of formula (I), and salts thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various diseases, such as allergic rhinitis.
摘要翻译： 本发明涉及式（I）化合物及其盐，其制备方法，含有它们的组合物及其在治疗各种疾病如过敏性鼻炎中的用途。
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![3- (4-{ [4- (4-{ [3-(3, 3-Dimethyl-1-Piperidinyl) Propyl] Oxy} Phenyl) -1-Piperidinyl] Carbonyl}-1-Naphthalenyl) Propanoic or Propenoic Acid as H1 and H3 Receptor Antagonists for the Treatment of Inflammatory and/or Allergic Disorders](/abs-image/US/2008/12/18/US20080312280A1/abs.jpg.150x150.jpg)
3.发明申请3- (4-{ [4- (4-{ [3-(3, 3-Dimethyl-1-Piperidinyl) Propyl] Oxy} Phenyl) -1-Piperidinyl] Carbonyl}-1-Naphthalenyl) Propanoic or Propenoic Acid as H1 and H3 Receptor Antagonists for the Treatment of Inflammatory and/or Allergic Disorders 失效3-（4 - {[4-（4 - {[3-（3,3-二甲基-1-哌啶基）丙基]氧基}苯基）-1-哌啶基]羰基} -1-萘基）丙酸或丙烯酸 H1和H3受体拮抗剂治疗炎性和/或过敏性疾病公开(公告)号：US20080312280A1
公开(公告)日：2008-12-18
申请号：US12158185
申请日：2006-12-19
IPC分类号： A61K31/4545 , C07D401/12
CPC分类号： C07D211/20
摘要： The present invention relates to a compound of formula (I), or a salt thereof wherein the naphthalene ring is substituted in the 2, 3, 4, 5, 6, 7 or 8 position by R1, and R1 represents —CH2CH2COOH or —CH═C(CH3)COOH, and to processes for their preparation, to compositions containing them and to their use in the treatment of various inflammatory and/or allergic diseases, such as diseases such as allergic rhinitis.
摘要翻译： 本发明涉及式（I）化合物或其盐，其中萘环在取代的2,3,4,5,6,7或8位，R1表示-CH2CH2COOH或-CH -C（CH 3）COOH，并且其制备方法，含有它们的组合物及其在治疗各种炎性和/或过敏性疾病例如过敏性鼻炎等疾病中的用途。
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公开(公告)号：US08357716B2
公开(公告)日：2013-01-22
申请号：US13202139
申请日：2010-02-24
申请人： Heather Hobbs , Simon Teanby Hodgson , Yannick Maurice LaCroix , Deborah Needham , Nigel James Parr , Panayiotis Alexandrou Procopiou , Timothy John Ritchie , Michael David Woodrow
发明人： Heather Hobbs , Simon Teanby Hodgson , Yannick Maurice LaCroix , Deborah Needham , Nigel James Parr , Panayiotis Alexandrou Procopiou , Timothy John Ritchie , Michael David Woodrow
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： C07D409/12 , C07D409/14 , C07D413/14
摘要： Indazole compounds, processes for their preparation, intermediates usable in these processes, pharmaceutical compositions containing such compounds and their use in therapy.
摘要翻译： 吲唑化合物，其制备方法，可用于这些方法的中间体，含有这些化合物的药物组合物及其在治疗中的用途。
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5.发明申请公开(公告)号：US20100222349A1
公开(公告)日：2010-09-02
申请号：US12681968
申请日：2008-10-15
申请人： Paul Martin Gore , Ashley Paul Hancock , Simon Teanby Hodgson , Michael Joachim Kranz , Panayiotis Alexandrou Procopiou , Sadie Vile
发明人： Paul Martin Gore , Ashley Paul Hancock , Simon Teanby Hodgson , Michael Joachim Kranz , Panayiotis Alexandrou Procopiou , Sadie Vile
IPC分类号： A61K31/5377 , C07D401/14 , A61K31/4709 , C07D413/14 , A61P37/08 , A61P11/06
CPC分类号： C07D401/12 , C07D401/14 , C07D413/14
摘要： The present invention relates to compounds of formula (I) and salts thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various diseases, such as allergic rhinitis.
摘要翻译： 本发明涉及式（I）化合物及其盐，其制备方法，含有它们的组合物及其在治疗各种疾病如过敏性鼻炎中的用途。
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公开(公告)号：US20120015932A1
公开(公告)日：2012-01-19
申请号：US13202139
申请日：2010-02-24
申请人： Heather Hobbs , Simon Teanby Hodgson , Yannick Maurice LaCroix , Deborah Needham , Nigel James Parr , Panayiotis Alexandrou Procopiou , Timothy John Ritchie , Michael David Woodrow
发明人： Heather Hobbs , Simon Teanby Hodgson , Yannick Maurice LaCroix , Deborah Needham , Nigel James Parr , Panayiotis Alexandrou Procopiou , Timothy John Ritchie , Michael David Woodrow
IPC分类号： A61K31/416 , C07D413/14 , C07D409/14 , A61K31/5377 , A61P29/00 , A61K31/496 , A61K31/422 , A61K31/4178 , A61P37/00 , C07D409/12 , A61K31/454
CPC分类号： C07D409/12 , C07D409/14 , C07D413/14
摘要： Indazole compounds, processes for their preparation, intermediates usable in these processes, pharmaceutical compositions containing such compounds and their use in therapy.
摘要翻译： 吲唑化合物，其制备方法，可用于这些方法的中间体，含有这些化合物的药物组合物及其在治疗中的用途。
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公开(公告)号：US08507543B2
公开(公告)日：2013-08-13
申请号：US13633382
申请日：2012-10-02
IPC分类号： A61K31/415
CPC分类号： C07D409/12 , C07D409/14 , C07D413/14
摘要： Indazole compounds, processes for their preparation, intermediates usable in these processes, pharmaceutical compositions containing such compounds and their use in therapy.
摘要翻译： 吲唑化合物，其制备方法，可用于这些方法的中间体，含有这些化合物的药物组合物及其在治疗中的用途。
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![3-(4-{ [4-(4-{ [3-(3, 3-dimethyl-1-piperidinyl) propyl] oxy} phenyl)-1-piperidinyl] carbonyl}-1-naphthalenyl) propanoic or propenoic acid as H1 and H3 receptor antagonists for the treatment of inflammatory and/or allergic disorders](/abs-image/US/2011/08/02/US07989629B2/abs.jpg.150x150.jpg)
8.发明授权3-(4-{ [4-(4-{ [3-(3, 3-dimethyl-1-piperidinyl) propyl] oxy} phenyl)-1-piperidinyl] carbonyl}-1-naphthalenyl) propanoic or propenoic acid as H1 and H3 receptor antagonists for the treatment of inflammatory and/or allergic disorders 失效3-（4 - {[4-（4 - {[3-（3,3-二甲基-1-哌啶基）丙基]氧基}苯基）-1-哌啶基]羰基} -1-萘基）丙酸或丙烯酸 H1和H3受体拮抗剂用于治疗炎性和/或过敏性疾病公开(公告)号：US07989629B2
公开(公告)日：2011-08-02
申请号：US12158185
申请日：2006-12-19
IPC分类号： C07D211/20 , A61K31/451
CPC分类号： C07D211/20
摘要： The present invention relates to a compound of formula (I), or a salt thereof wherein the naphthalene ring is substituted in the 2, 3, 4, 5, 6, 7 or 8 position by R1, and R1 represents —CH2CH2COOH or —CH═C(CH3)COOH, and to processes for their preparation, to compositions containing them and to their use in the treatment of various inflammatory and/or allergic diseases, such as diseases such as allergic rhinitis.
摘要翻译： 本发明涉及式（I）化合物或其盐，其中萘环在取代的2,3,4,5,6,7或8位，R1表示-CH2CH2COOH或-CH （C 3）COOH，以及其制备方法，含有它们的组合物及其在治疗各种炎症和/或过敏性疾病例如过敏性鼻炎等疾病中的用途。
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公开(公告)号：US07884114B2
公开(公告)日：2011-02-08
申请号：US12190868
申请日：2008-08-13
申请人： Paul Martin Gore , Ashley Paul Hancock , Simon Teanby Hodgson , Panayiotis Alexandrou Procopiou , Sadie Vile
发明人： Paul Martin Gore , Ashley Paul Hancock , Simon Teanby Hodgson , Panayiotis Alexandrou Procopiou , Sadie Vile
IPC分类号： C07D215/38 , A61K31/04
CPC分类号： C07D409/14 , C07D401/12
摘要： The present invention relates to a compound which is N-(4-{4-[(6-butyl-8-quinolinyl)oxy]-1-piperidinyl}butyl)ethanesulfonamide and salts thereof, processes for its preparation, to compositions containing it and to its use in the treatment of various diseases, such as allergic rhinitis.
摘要翻译： 本发明涉及一种化合物，其是N-（4- {4 - [（6-丁基-8-喹啉基）氧基] -1-哌啶基}丁基）乙磺酰胺及其盐，其制备方法，含有它的组合物 并用于治疗各种疾病，如过敏性鼻炎。
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公开(公告)号：US20090270355A1
公开(公告)日：2009-10-29
申请号：US12190868
申请日：2008-08-13
申请人： Paul Martin Gore , Ashley Paul Hancock , Simon Teanby Hodgson , Panayiotis Alexandrou Procopiou , Sadie Vile
发明人： Paul Martin Gore , Ashley Paul Hancock , Simon Teanby Hodgson , Panayiotis Alexandrou Procopiou , Sadie Vile
IPC分类号： A61K31/4709 , C07D401/12 , A61K31/56 , A61P29/00 , A61P37/00
CPC分类号： C07D409/14 , C07D401/12
摘要： The present invention relates to a compound which is N-(4-{4-[(6-butyl-8-quinolinyl)oxy]-1-piperidinyl}butyl)ethanesulfonamide and salts thereof, processes for its preparation, to compositions containing it and to its use in the treatment of various diseases, such as allergic rhinitis.
摘要翻译： 本发明涉及一种化合物，其是N-（4- {4 - [（6-丁基-8-喹啉基）氧基] -1-哌啶基}丁基）乙磺酰胺及其盐，其制备方法，含有它的组合物 并用于治疗各种疾病，如过敏性鼻炎。
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