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14 条记录 (耗时 0.021 秒)

    3-Sulfonate ester of 2,3-dihydroxypropylamine
    1.
    发明授权
    3-Sulfonate ester of 2,3-dihydroxypropylamine 失效
    2,3-二羟基丙胺的3-磺酸酯

    公开(公告)号：US4031125A

    公开(公告)日：1977-06-21

    申请号：US625616

    申请日：1975-10-24

    申请人： Leonard M. Weinstock ,  Roger J. Tull ,  Dennis M. Mulvey

    发明人： Leonard M. Weinstock ,  Roger J. Tull ,  Dennis M. Mulvey

    IPC分类号： C07C309/63 ,  C07D285/10 ,  C07C143/68

    CPC分类号： C07D285/10 ,  C07C309/63

    摘要： Preparation of an optically active alkamine in the sinister configuration, or a derivative of said alkamine, which is reacted with an 3-X-4-chloro(or RO- where R is hydrogen or an alkali metal)-1,2,5-thiadiazole to prepare S-3-X-4-(3-substituted amino-2-hydroxypropoxy)-1,2,5-thiadiazole beta adrenergic blocking agents. Novel 3-morpholino-4-chloro(or RO-)-1,2,5-thiadiazoles and their preparation also are described.

    摘要翻译： 制备呈阴性构型的光学活性烷胺或所述烷胺的衍生物，其与3-X-4-氯（或RO-，其中R为氢或碱金属） 噻吩并制备S-3-X-4-（3-取代氨基-2-羟基丙氧基）-1,2,5-噻二唑β肾上腺素能阻断剂。 还描述了新的3-吗啉代-4-氯（或RO - ） - 1,2,5-噻二唑及其制备方法。

    Sinister-3,5-disubstituted oxozolidines their preparation and use
    3.
    发明授权
    Sinister-3,5-disubstituted oxozolidines their preparation and use 失效
    辛酯-3,5-二取代的氧代唑烷其制备和用途

    公开(公告)号：US4051144A

    公开(公告)日：1977-09-27

    申请号：US529314

    申请日：1974-12-04

    申请人： Leonard M. Weinstock ,  Roger J. Tull ,  Dennis M. Mulvey

    发明人： Leonard M. Weinstock ,  Roger J. Tull ,  Dennis M. Mulvey

    IPC分类号： C07C309/63 ,  C07D263/06 ,  C07D285/10 ,  C07D263/04

    CPC分类号： C07D285/10 ,  C07C309/63 ,  C07D263/06

    摘要： Preparation of S-3-X-4-(3-substituted amino-2-hydroxypropoxy)-1,2,5-thiadiazole beta adrenergic blocking agents using as starting material an optically active alkalmine in the sinister configuration, or a derivative of said alkamine, which is reacted with an 3-X-4-chloro(or RO-where R is hydrogen or an alkali metal)-1,2,5-thiadiazole. Certain3-morpholino-4-chloro(or RO-)-1,2,5-thiadiazoles and certain alkamines and their preparation also are described. Preferred alkamines are S-3,5-disubstituted oxazolidines.

    摘要翻译： 制备S-3-X-4-（3-取代氨基-2-羟基丙氧基）-1,2,5-噻二唑β肾上腺素能阻断剂，以阴性配置使用光学活性碱，或所述 烷基胺与3-X-4-氯（或RO-，其中R是氢或碱金属）-1,2,5-噻二唑反应。 还描述了某些3-吗啉代-4-氯（或RO - ） - 1,2,5-噻二唑和某些烷胺及其制备方法。 优选的烷胺是S-3,5-二取代的恶唑烷。

    Preparation of fluorinated anilines
    4.
    发明授权
    Preparation of fluorinated anilines 失效
    氟化物的制备

    公开(公告)号：US4145364A

    公开(公告)日：1979-03-20

    申请号：US855649

    申请日：1977-11-30

    申请人： Dennis M. Mulvey ,  Leonard M. Weinstock

    发明人： Dennis M. Mulvey ,  Leonard M. Weinstock

    IPC分类号： C07C85/11

    CPC分类号： C07C247/00

    摘要： Fluorinated anilines, especially p-fluoroaniline and 2,4-difluoroaniline, are prepared by treating aromatic azides with anhydrous hydrogen fluoride. The aromatic azides, in turn, are prepared from the corresponding anilines by treatment with nitrous acid or salt thereof and an alkali metal azide in the presence of a mineral acid, and in an aqueous-nonaqueous, two-phase environment.

    Preparation of salicylic acid and derivatives
    5.
    发明授权
    Preparation of salicylic acid and derivatives 失效
    水杨酸及其衍生物的制备

    公开(公告)号：US4131618A

    公开(公告)日：1978-12-26

    申请号：US865563

    申请日：1977-12-29

    申请人： Leonard M. Weinstock ,  Arthur S. Wildman ,  Dennis M. Mulvey

    发明人： Leonard M. Weinstock ,  Arthur S. Wildman ,  Dennis M. Mulvey

    IPC分类号： C07C65/01 ,  C07C51/00 ,  C07C51/15 ,  C07C65/21 ,  C07C67/00 ,  C07C65/14

    CPC分类号： C07C51/15

    摘要： The invention relates to an improved method of preparing salicylic acid and derivatives from phenyl esters which comprises the step of fusing acetoxyphenyl, or derivative suitable for preparing the desired salicylic acid derivative, with M.sub.2 CO.sub.3 where M is potassium or sodium in the presence of carbon dioxide, at a temperature of from 150.degree. to 250.degree. C., and at a pressure of from atmospheric to 500 p.s.i.g.

    摘要翻译： {PG，1本发明涉及一种制备水杨酸及其衍生物的改进方法，该方法包括将适合制备所需水杨酸衍生物的乙酰氧基苯基或衍生物与M（HD 2 {L CO {HD 3 {L，其中M为二氧化碳存在下的钾或钠，温度为150℃（20〜250℃，20〜20℃，压力为500psig）