公开(公告)号：US4705782A

公开(公告)日：1987-11-10

申请号：US844146

申请日：1986-03-26

申请人： Robert T. Logan ,  James Redpath ,  Robert G. Roy

发明人： Robert T. Logan ,  James Redpath ,  Robert G. Roy

IPC分类号： A61K31/16 ,  A61K31/175 ,  A61K31/335 ,  A61K31/357 ,  A61P9/04 ,  C07C67/00 ,  C07C239/00 ,  C07C257/10 ,  C07C259/06 ,  C07C259/18 ,  C07C281/16 ,  C07C281/18 ,  C07D317/70 ,  C07C93/10 ,  A61K31/05 ,  A61K31/155 ,  C07C131/00

CPC分类号： C07C259/18 ,  C07C281/18

摘要： The invention relates to compounds of the general formula I ##STR1## wherein R.sub.1 represents one up to and including four, the same or different substituents selected from alkyl(1-6 C), alkoxy(1-6 C), hydroxy, halogen, NO.sub.2, CF.sub.3 or the group --NR.sub.5 R.sub.6,whereby two substituents taken together may also represent a methylene-dioxy group,X represents a member selected from ##STR2## --CH.sub.2 --CH.sub.2 -- and --CH.dbd.CH--, n has the value 0, 1 or 2,R.sub.3 represents one of the moieties: ##STR3## and R.sub.2, R.sub.4, R.sub.5 and R.sub.6 represent hydrogen or alkyl(1-6 C),and pharmaceutically acceptable salts thereof, suitable in the treatment of heartfailure.

摘要翻译： 本发明涉及通式Ⅰ的化合物，其中R 1代表一个至多并包括四个相同或不同的选自烷基（1-6C），烷氧基（1-6C），羟基，卤素， NO 2，CF 3或基团-NR 5 R 6，其中两个取代基一起也可以表示亚甲基 - 二氧基，X表示选自R4CH，+ RF-CH2-CH2-和-CH = CH-的成员，n的值为0 ，1或2，R 3表示下列部分之一：其中R2，R4，R5和R6代表氢或烷基（1-6C）及其药学上可接受的盐，适用于治疗心脏衰竭。

公开(公告)号：US4248796A

公开(公告)日：1981-02-03

申请号：US963607

申请日：1978-11-24

申请人： Patrick M. Quinlan

发明人： Patrick M. Quinlan

IPC分类号： C23F11/04 ,  C23F11/14 ,  C23G1/06 ,  C07C93/10 ,  A01N33/02 ,  C07C93/12

CPC分类号： C23G1/068 ,  C23F11/04 ,  C23F11/142

摘要： This invention relates to quaternaries of alkynoxymethyl amines and uses thereof. These may be summarized by the following formulae: ##STR1## where R and R' are substituted groups such as alkyl, aryl, etc.; R'" is an acetylenic group; and X is an anion; and ##STR2## where R and R'" having the same meaning as in (1) and Z is a bridging group, preferably hydrocarbon such as alkylene, alkinylene, alkenylene, arylene, etc.

摘要翻译： 本发明涉及炔氧基甲胺的季胺及其用途。 这些可以由下列公式总结：其中R和R'是取代基如烷基，芳基等; R“'是炔基; X为阴离子; （2）其中R和R“具有与（1）中相同的含义，Z为桥连基团，优选烃如亚烷基，亚炔基，亚烯基，亚芳基等。

公开(公告)号：US3658902A

公开(公告)日：1972-04-25

申请号：US3658902D

申请日：1969-08-21

申请人： SCM CORP

发明人： BORDENCA CARL

IPC分类号： A01N33/08 ,  C07C93/10 ,  C07C93/12

CPC分类号： A01N33/08

摘要： COMPOUNDS OF THE FORMULA:

A-N(-A'')-(R-O)N-Z-(O-R)N-N(-A)-A''

WHERE THE GROUPS REPRESENTED BY A AND A'' ARE LIKE OR DISSIMILAR ALKYL, R IS LOWER ALKYLENE, Z IS AN ALKYNYIENE GROUP CONTAINING FROM 4 TO 16 CARBON ATOMS AND N IS A NUMBER OF FROM 1 TO 15 AND STABLE SALTS THEREOF. ALSO DESCRIBED ARE STABLE SALTS OF THE ABOVE COMPOUNDS AND COMPOSITIONS CONTAINING THE COMPOUNDS AND SALTS, AS WELL AS PROCESSES FOR CONTROLLING ARACHNIDS. COMPOUNDS, COMPOSITIONS, AND PROCESSES ARE ADVANTAGEOUS IN THAT THEY PROVIDE EFFECTIVE MEANS OF CONTROLLING ARACHNIDS SUCH AS, FOR EXAMPLE, MITES, SPIDERS, TICKS, AND THE LIKE WITHOUT HARMING HUMAN BEINGS OR ANIMAL WILDLIFE.

公开(公告)号：US4419354A

公开(公告)日：1983-12-06

申请号：US384461

申请日：1982-06-03

申请人： Ralph G. Child ,  Stanley A. Lang, Jr.

发明人： Ralph G. Child ,  Stanley A. Lang, Jr.

IPC分类号： C07D295/092 ,  A61K31/13 ,  A61K31/535 ,  C07C93/10 ,  C07D265/30

CPC分类号： C07D295/088 ,  Y10S514/885

摘要： This disclosure describes certain substituted 9,10-bis(2-aminoethoxy)anthracenes which are useful as modulators of the immune response system in warm-blooded animals and for inducing the regression of tumors in such animals.

摘要翻译： 本公开内容描述了某些取代的9,10-双（2-氨基乙氧基）蒽，其可用作温血动物中的免疫应答系统的调节剂，并用于诱导这些动物中肿瘤的消退。

公开(公告)号：US4026946A

公开(公告)日：1977-05-31

申请号：US556332

申请日：1975-03-07

申请人： Patrick M. Quinlan

发明人： Patrick M. Quinlan

IPC分类号： C02F1/50 ,  C09K8/60 ,  C23F11/04 ,  C23G1/06 ,  C07C93/10 ,  C07C93/08 ,  C07C93/12 ,  C23F11/00

CPC分类号： C09K8/605 ,  C02F1/50 ,  C23F11/04 ,  C23G1/068 ,  Y10S507/934 ,  Y10S507/939

摘要： This invention relates to halogen derivatives of alkynoxymethylamines and to uses thereof. The present invention may be ideally illustrated by the following equation:RN(CH.sub.2 OR'C.tbd.CH).sub.2 + 2NaOX .fwdarw. RN(CH.sub.2 OR'C.tbd.CX).sub.2 + 2NaOHwhere R is a substituted group, preferably hydrocarbon, such as alkyl, cycloalkyl, aryl, etc., R' is hydrocarbon, preferably alkylene, and where X is halogen.

摘要翻译： 本发明涉及炔氧基甲胺的卤素衍生物及其用途。 本发明可以通过以下等式理想地说明：

公开(公告)号：US3891709A

公开(公告)日：1975-06-24

申请号：US36946973

申请日：1973-06-13

申请人： DAICEL LTD

发明人： HIGUCHI MASARU ,  OHNAKA KOUICHI

IPC分类号： C08K5/00 ,  C08J7/04 ,  C08J7/06 ,  C08K5/17 ,  C08L1/00 ,  C08L23/00 ,  C08L27/00 ,  C08L67/00 ,  C08L77/00 ,  C08L101/00 ,  C09K3/16 ,  C07C93/10

CPC分类号： C08J7/065 ,  C08K5/17 ,  C08L27/06

摘要： An antistatic agent for plastics comprising a compound of the formula

WHEREIN R1 is alkyl having 7 to 29 carbon atoms, R2 is hydrogen or alkyl having 1 or 2 carbon atoms, R3 is lower alkyl having 1 to 4 carbon atoms or a hydroxyalkyl group of the formula

(IN WHICH R5 is hydrogen or alkyl having 1 or 2 carbon atoms and y is an integer of from 1 to 3), R4 is lower alkyl having 1 to 4 carbon atoms or a hydroxyalkyl group of the formula

(IN WHICH R6 is hydrogen or alkyl having 1 or 2 carbon atoms and z is an integer of from 1 to 3), and x is an integer of from 1 to 3. The agent can be mixed in molding compositions and it also can be applied as a coating on molded articles.

摘要翻译： 一种用于塑料的抗静电剂，其包含下式的化合物，其中R 1是具有7至29个碳原子的烷基，R 2是氢或具有1或2个碳原子的烷基，R 3是具有1至4个碳原子的低级烷基或 式（其中R5是氢或具有1或2个碳原子且y是1至3的整数的烷基），R4是具有1至4个碳原子的低级烷基或式（其中R6是氢）的羟烷基 或具有1或2个碳原子的烷基，z是1至3的整数），x是1至3的整数。

公开(公告)号：US3681462A

公开(公告)日：1972-08-01

申请号：US3681462D

申请日：1969-07-31

申请人： SCM CORP

发明人： BORDENCA CARL

IPC分类号： C07C91/24 ,  C07C93/10

CPC分类号： C07C217/08

摘要： Compounds of the formula: WHERE Z is selected from the group consisting of alkynyl and hydroxy substituted alkynyl groups having from five to 10 carbon atoms, R1 is lower alkylene containing from one to six carbon atoms in the alkylene group and R2 and R3 are like or dissimilar lower alkyl and stable salts thereof. Also described are compositions containing the compounds as well as processes for controlling arachnids. The compounds, compositions, and processes are advantageous in that they provide effective means of controlling arachnids, such as mites, spiders, and ticks without harming human beings and animal wildlife.

摘要翻译： 下式的化合物：

公开(公告)号：US4578462A

公开(公告)日：1986-03-25

申请号：US525529

申请日：1983-08-22

申请人： Hans-Jurgen Hansen ,  Rudolf Schmid ,  Max Schmid

发明人： Hans-Jurgen Hansen ,  Rudolf Schmid ,  Max Schmid

IPC分类号： C07C17/093 ,  C07D295/084 ,  C07F9/50 ,  C07F15/00 ,  C07C93/10 ,  C07D295/08

CPC分类号： C07D295/084 ,  C07C17/093 ,  C07F15/0006 ,  C07F15/0066 ,  C07F15/008 ,  C07F9/5027

摘要： The manufacture of optically active bifunctional compounds of the general formula ##STR1## wherein R represents protected hydroxymethyl, protected formyl or alkoxycarbonyl and R.sup.1 represents a group of the formula ##STR2## or --CH.sub.2 --CH.dbd.NR.sup.2 in which R.sup.2 and R.sup.3 represent lower alkyl or cycloalkyl or R.sup.2 and R.sup.3 together with the nitrogen atom represent a heterocyclic ring,by isomerizing compounds of the general formula ##STR3## wherein R, R.sup.2 and R.sup.3 have the above significance and R.sup.3 can additionally signify hydrogen,is described.The compounds of formula I are potential intermediates in the manufacture of, inter alia, natural vitamin E and natural vitamin K.sub.1.

摘要翻译： 制备通式为“IMAGE”I的光学活性双官能化合物，其中R表示被保护的羟甲基，受保护的甲酰基或烷氧基羰基，R 1表示下式的基团：其中R 2和R 3表示较低的式“IMAGE”或-CH 2 -CH = NR 2 烷基或环烷基或R 2和R 3与氮原子一起表示杂环，通过异构化通式为II，其中R，R 2和R 3具有上述含义并且R 3可以另外表示氢的化合物。 式I化合物是天然维生素E和天然维生素K1的制造中的潜在中间体。

公开(公告)号：US3962338A

公开(公告)日：1976-06-08

申请号：US417301

申请日：1973-11-19

申请人： Leonard M. Weinstock ,  Roger J. Tull ,  Dennis M. Mulvey

发明人： Leonard M. Weinstock ,  Roger J. Tull ,  Dennis M. Mulvey

IPC分类号： C07C309/63 ,  C07D263/06 ,  C07D285/10 ,  C07C91/02 ,  C07C93/02 ,  C07C93/10 ,  C07C95/02

CPC分类号： C07D285/10 ,  C07C309/63 ,  C07D263/06

摘要： Preparation of an optically active alkamine in the sinister configuration, or a derivative of said alkamine, which is reacted with an 3-X-4-chloro(or RO-- where R is hydrogen or an alkali metal)-1,2,5-thiadiazole to prepare S-3-X-4-(3-substituted amino-2-hydroxypropoxy)-1,2,5-thiadiazole beta adrenergic blocking agents. Novel 3-morpholino-4-chloro(or RO--)-1,2,5-thiadiazoles and their preparation also are described.

摘要翻译： 制备呈阴性构型的光学活性烷胺或所述烷胺的衍生物，其与3-X-4-氯（或RO-，其中R为氢或碱金属） 噻吩并制备S-3-X-4-（3-取代氨基-2-羟基丙氧基）-1,2,5-噻二唑β肾上腺素能阻断剂。 还描述了新的3-吗啉代-4-氯（或RO - ） - 1,2,5-噻二唑及其制备方法。

公开(公告)号：US3953512A

公开(公告)日：1976-04-27

申请号：US452372

申请日：1974-03-18

申请人： Czeslaw Belzecki ,  Witold Tomasik ,  Jerzy Trojnar

发明人： Czeslaw Belzecki ,  Witold Tomasik ,  Jerzy Trojnar

IPC分类号： C07C67/00 ,  C07C213/00 ,  C07C213/04 ,  C07C215/08 ,  C07D203/08 ,  C07C91/02 ,  C07C93/02 ,  C07C93/10 ,  C07C95/02

CPC分类号： C07D203/08

摘要： The invention relates to a method of preparation of 2-aminobutanol from readily available raw materials. The method of this invention is based on the reaction between 1.2-epoxybutane or isomeric butylene halogenehydrines with ammonia. The product, isomeric aminobutanols, are, subsequently transformed into 2-ethylaziridine by means of esterification with sulphuric acid followed by treatment with alkali. 2-Ethylaziridine is then submitted to a reaction with aromatic carboxylic acid or with aromatic orthobicarboxylic acid anhydride which produces the corresponding monomeric or polymeric amide, which is transformed into 2-aminobutanol by hydrolysis.The method of this invention is a multistage one but is quite simple and employs aqueous solutions and organic solvents, such as chloroform or benzene, which may be easily recovered.

摘要翻译： 本发明涉及从容易获得的原料制备2-氨基丁醇的方法。 本发明的方法是基于1,2-环氧丁烷或异构丁烯卤化氢与氨的反应。 产物异构氨基丁醇随后通过用硫酸酯化转化成2-乙基氮丙啶，然后用碱处理。 然后将2-乙基氮丙啶与芳族羧酸或芳族邻苯二甲酸酐反应，产生相应的单体或聚合酰胺，其通过水解转化为2-氨基丁醇。