公开(公告)号：US20140256052A1

公开(公告)日：2014-09-11

申请号：US13788283

申请日：2013-03-07

Applicant: MEDTRONIC, INC.

Inventor： Charlene Yuan ,  Trevor Huang

IPC: G01N33/86

CPC classification number: G01N33/86 ,  G01N33/4905

Abstract: The invention includes systems, apparatuses and methods to evaluate the strength of clotting in addition to or separate from activated clotting time. The strength of clotting may be correlated with the amount of energy employed to move an object within blood. The strength of clotting may be correlated with the amount of time for fibrinolysis to occur. The strength of clotting may be determined by a system in which a ferromagnetic material is moved within blood.

Abstract translation: 本发明包括用于评估除活化凝血时间之外或与活化凝血时间分离的凝血强度的系统，装置和方法。 凝血的强度可能与在血液中移动物体所用的能量的量相关。 凝血的强度可能与发生纤维蛋白溶解的时间量相关。 凝血的强度可以通过其中铁磁材料在血液内移动的系统来确定。

公开(公告)号：US20160238621A1

公开(公告)日：2016-08-18

申请号：US15135327

申请日：2016-04-21

Applicant: Medtronic, Inc.

Inventor： Daniel Cheek ,  Lawrence Erickson ,  Trevor Huang ,  Tessy Kanayinkal ,  Craig Petersen ,  Charlene Yuan

IPC: G01N33/86

CPC classification number: G01N33/4905 ,  G01N33/86

Abstract: Activated clotting time (ACT) tests detect blood clotting time based on the viscosity changes of a test sample, using a ferromagnetic washer lifted to the top of a test chamber and then dropped from the top via gravity; a drop time greater than a preset threshold value indicates clotting of the test sample. Blood samples which have high levels of heparin usually produce very weak clots that may easily be destroyed by the lifting movement of the washer. But if the clot threshold is set low to detect the weak clots, false detections occur during early testing cycles when activators are not fully suspended during the mixing cycle. Improved algorithms for lifting the washer and adjusting over time enable accurate detection of weak clots.

公开(公告)号：US20130144538A1

公开(公告)日：2013-06-06

申请号：US13706453

申请日：2012-12-06

Applicant: MEDTRONIC, INC.

Inventor： Daniel Cheek ,  Lawrence Erickson ,  Trevor Huang ,  Tessy Kanayinkal ,  Craig Petersen ,  Charlene Yuan

IPC: G01N33/49

CPC classification number: G01N33/4905 ,  G01N33/86

Abstract: Activated clotting time (ACT) tests detect blood clotting time based on the viscosity changes of a test sample, using a ferromagnetic washer lifted to the top of a test chamber and then dropped from the top via gravity; a drop time greater than a preset threshold value indicates clotting of the test sample. Blood samples which have high levels of heparin usually produce very weak clots that may easily be destroyed by the lifting movement of the washer. But if the clot threshold is set low to detect the weak clots, false detections occur during early testing cycles when activators are not fully suspended during the mixing cycle. Improved algorithms for lifting the washer and adjusting over time enable accurate detection of weak clots.

Abstract translation: 活化凝血时间（ACT）测试根据测试样品的粘度变化检测血液凝固时间，使用提升到测试室顶部的铁磁垫圈，然后通过重力从顶部滴落; 大于预设阈值的下降时间表示测试样品的凝血。 具有高水平肝素的血液样品通常产生非常弱的凝块，这可能容易被洗涤器的提升运动所破坏。 但是，如果凝块阈值设置为低以检测弱凝块，则在早期测试周期期间发生错误检测，当激活剂在混合循环期间未完全悬浮时。 用于提升洗衣机和随时间调整的改进的算法可以准确检测弱凝块。

公开(公告)号：US10379128B2

公开(公告)日：2019-08-13

申请号：US13868598

申请日：2013-04-23

Applicant: Medtronic, Inc.

Inventor： Charlene Yuan ,  Trevor Huang

IPC: G01N33/86 ,  G01N33/49

Abstract: Systems, apparatuses and methods include evaluation the clotting time or strength of clotting in the presence of various clot-affecting reagents to obtain a profile of clot analysis for determination of bleeding complications. The various reagents may be included in a single cartridge for use in a blood clotting analysis device.

公开(公告)号：US20180172665A1

公开(公告)日：2018-06-21

申请号：US15383995

申请日：2016-12-19

Applicant: Medtronic, Inc.

Inventor： Charlene Yuan ,  Trevor Huang ,  Tessy Kanayinkal

IPC: G01N33/49 ,  G01N15/05 ,  G01N27/74

CPC classification number: G01N33/4905 ,  G01N15/05

Abstract: A method carried out by a system configured to analyze blood. The method includes causing a ferromagnetic object to move in a chamber housing blood after clot initiation has been implicated. Movement of the object in the chamber is detected. The detected movement of the object is correlated with clot retraction of the blood. In some embodiments, the stop of detecting movement includes allowing the object to drop from a raised position and detecting a drop distance of the object. In related embodiments, the step of correlating detected movement with clot retraction includes reviewing a trace generated by a plurality of drop distances over time. In yet other embodiments, methods of the present disclosure can further including evaluating platelet function of the blood based upon assessed clot retraction.

公开(公告)号：US08921115B2

公开(公告)日：2014-12-30

申请号：US13788283

申请日：2013-03-07

Applicant: Medtronic, Inc.

Inventor： Charlene Yuan ,  Trevor Huang

IPC: G01N33/86 ,  G01N33/48

CPC classification number: G01N33/86 ,  G01N33/4905

Abstract: The invention includes systems, apparatuses and methods to evaluate the strength of clotting in addition to or separate from activated clotting time. The strength of clotting may be correlated with the amount of energy employed to move an object within blood. The strength of clotting may be correlated with the amount of time for fibrinolysis to occur. The strength of clotting may be determined by a system in which a ferromagnetic material is moved within blood.

Abstract translation: 本发明包括用于评估除活化凝血时间之外或与活化凝血时间分离的凝血强度的系统，装置和方法。 凝血的强度可能与在血液中移动物体所用的能量的量相关。 凝血的强度可能与发生纤维蛋白溶解的时间量相关。 凝血的强度可以通过其中铁磁材料在血液内移动的系统来确定。

公开(公告)号：US11275076B2

公开(公告)日：2022-03-15

申请号：US15383995

申请日：2016-12-19

Applicant: Medtronic, Inc.

Inventor： Charlene Yuan ,  Trevor Huang ,  Tessy Kanayinkal

IPC: G01N33/49 ,  G01N15/05

Abstract: A method carried out by a system configured to analyze blood. The method includes causing a ferromagnetic object to move in a chamber housing blood after clot initiation has been implicated. Movement of the object in the chamber is detected. The detected movement of the object is correlated with clot retraction of the blood. In some embodiments, the stop of detecting movement includes allowing the object to drop from a raised position and detecting a drop distance of the object. In related embodiments, the step of correlating detected movement with clot retraction includes reviewing a trace generated by a plurality of drop distances over time. In yet other embodiments, methods of the present disclosure can further including evaluating platelet function of the blood based upon assessed clot retraction.

公开(公告)号：US10371694B2

公开(公告)日：2019-08-06

申请号：US15135327

申请日：2016-04-21

Applicant: Medtronic, Inc.

Inventor： Daniel Cheek ,  Lawrence Erickson ,  Trevor Huang ,  Tessy Kanayinkal ,  Craig Petersen ,  Charlene Yuan

IPC: G01N33/49 ,  G01N33/86

Abstract: Activated clotting time (ACT) tests detect blood clotting time based on the viscosity changes of a test sample, using a ferromagnetic washer lifted to the top of a test chamber and then dropped from the top via gravity; a drop time greater than a preset threshold value indicates clotting of the test sample. Blood samples which have high levels of heparin usually produce very weak clots that may easily be destroyed by the lifting movement of the washer. But if the clot threshold is set low to detect the weak clots, false detections occur during early testing cycles when activators are not fully suspended during the mixing cycle. Improved algorithms for lifting the washer and adjusting over time enable accurate detection of weak clots.

公开(公告)号：US09429563B2

公开(公告)日：2016-08-30

申请号：US13706453

申请日：2012-12-06

Applicant: Medtronic, Inc.

Inventor： Daniel Cheek ,  Lawrence Erickson ,  Trevor Huang ,  Tessy Kanayinkal ,  Craig Petersen ,  Charlene Yuan

IPC: G01N33/49

CPC classification number: G01N33/4905 ,  G01N33/86

Abstract: Activated clotting time (ACT) tests detect blood clotting time based on the viscosity changes of a test sample, using a ferromagnetic washer lifted to the top of a test chamber and then dropped from the top via gravity; a drop time greater than a preset threshold value indicates clotting of the test sample. Blood samples which have high levels of heparin usually produce very weak clots that may easily be destroyed by the lifting movement of the washer. But if the clot threshold is set low to detect the weak clots, false detections occur during early testing cycles when activators are not fully suspended during the mixing cycle. Improved algorithms for lifting the washer and adjusting over time enable accurate detection of weak clots.

Abstract translation: 活化凝血时间（ACT）测试根据测试样品的粘度变化检测血液凝固时间，使用提升到测试室顶部的铁磁垫圈，然后通过重力从顶部滴落; 大于预设阈值的下降时间表示测试样品的凝血。 具有高水平肝素的血液样品通常产生非常弱的凝块，这可能容易被洗涤器的提升运动所破坏。 但是，如果凝块阈值设置为低以检测弱凝块，则在早期测试周期期间发生错误检测，当激活剂在混合循环期间未完全悬浮时。 用于提升洗衣机和随时间调整的改进的算法可以准确检测弱凝块。

公开(公告)号：US20140315228A1

公开(公告)日：2014-10-23

申请号：US13868598

申请日：2013-04-23

Applicant: MEDTRONIC, INC.

Inventor： Charlene Yuan ,  Trevor Huang

IPC: G01N33/86

CPC classification number: G01N33/86 ,  G01N33/4905

Abstract: Systems, apparatuses and methods include evaluation the clotting time or strength of clotting in the presence of various clot-affecting reagents to obtain a profile of clot analysis for determination of bleeding complications. The various reagents may be included in a single cartridge for use in a blood clotting analysis device.

Abstract translation: 系统，装置和方法包括在各种凝块影响试剂的存在下评价凝血时间或凝血强度，以获得用于测定出血并发症的凝块分析的分布。 各种试剂可以包含在用于凝血分析装置中的单个药筒中。