公开(公告)号：US20140256052A1

公开(公告)日：2014-09-11

申请号：US13788283

申请日：2013-03-07

Applicant: MEDTRONIC, INC.

Inventor： Charlene Yuan ,  Trevor Huang

IPC: G01N33/86

CPC classification number: G01N33/86 ,  G01N33/4905

Abstract: The invention includes systems, apparatuses and methods to evaluate the strength of clotting in addition to or separate from activated clotting time. The strength of clotting may be correlated with the amount of energy employed to move an object within blood. The strength of clotting may be correlated with the amount of time for fibrinolysis to occur. The strength of clotting may be determined by a system in which a ferromagnetic material is moved within blood.

Abstract translation: 本发明包括用于评估除活化凝血时间之外或与活化凝血时间分离的凝血强度的系统，装置和方法。 凝血的强度可能与在血液中移动物体所用的能量的量相关。 凝血的强度可能与发生纤维蛋白溶解的时间量相关。 凝血的强度可以通过其中铁磁材料在血液内移动的系统来确定。

公开(公告)号：US20160238621A1

公开(公告)日：2016-08-18

申请号：US15135327

申请日：2016-04-21

Applicant: Medtronic, Inc.

Inventor： Daniel Cheek ,  Lawrence Erickson ,  Trevor Huang ,  Tessy Kanayinkal ,  Craig Petersen ,  Charlene Yuan

IPC: G01N33/86

CPC classification number: G01N33/4905 ,  G01N33/86

Abstract: Activated clotting time (ACT) tests detect blood clotting time based on the viscosity changes of a test sample, using a ferromagnetic washer lifted to the top of a test chamber and then dropped from the top via gravity; a drop time greater than a preset threshold value indicates clotting of the test sample. Blood samples which have high levels of heparin usually produce very weak clots that may easily be destroyed by the lifting movement of the washer. But if the clot threshold is set low to detect the weak clots, false detections occur during early testing cycles when activators are not fully suspended during the mixing cycle. Improved algorithms for lifting the washer and adjusting over time enable accurate detection of weak clots.

公开(公告)号：US20140273249A1

公开(公告)日：2014-09-18

申请号：US13795608

申请日：2013-03-12

Applicant: MEDTRONIC, INC.

Inventor： Charlene Yuan ,  Trevor C. Huang ,  Tessy Kanayinkal ,  Mary Jo Passenheim ,  Craig D. Petersen ,  Ivan Akunovich

IPC: G01N33/86

CPC classification number: G01N33/86 ,  G01N33/4905

Abstract: High range activated clotting time (HR-ACT) tests detect blood clotting time in blood samples which have high levels of heparin. Reagents such as calcium chloride and kaolin within the test apparatus trigger clotting. The cartridge is treated with a strong surface treatment process, such as an atmospheric plasma treatment, to increase the hydrophilic property of the test chamber, there may be a significant reduction in the kaolin concentration required to activate the blood sample and initiate the coagulation process. The kaolin concentration may be further reduced if the buffer component used in the buffer saline contains phosphate. The reduction of the kaolin concentration allows more calcium to be released from the kaolin to participate in the clotting process. The combined effect of adding a surface treatment to the cartridge to increase the hydrophilic property of reaction chamber and adding phosphate into buffered saline allows for clot detection of blood samples containing 5˜6 U/mL heparin.

Abstract translation: 高程激活凝血时间（HR-ACT）测试检测血液样品中具有高水平肝素的凝血时间。 试剂如氯化钙和高岭土等试剂触发凝血。 用强大的表面处理方法（例如大气等离子体处理）处理该盒，以增加试验室的亲水性能，激活血液样品并开始凝固过程所需的高岭土浓度可能会显着降低。 如果缓冲盐水中使用的缓冲液组分含有磷酸盐，则高岭土浓度可进一步降低。 高岭土浓度的降低允许从高岭土释放更多的钙以参与凝固过程。 加入表面处理以提高反应室的亲水性能并将磷酸盐添加到缓冲盐水中的综合效果允许凝块检测含有5〜6U / mL肝素的血液样品。

公开(公告)号：US20130144538A1

公开(公告)日：2013-06-06

申请号：US13706453

申请日：2012-12-06

Applicant: MEDTRONIC, INC.

Inventor： Daniel Cheek ,  Lawrence Erickson ,  Trevor Huang ,  Tessy Kanayinkal ,  Craig Petersen ,  Charlene Yuan

IPC: G01N33/49

CPC classification number: G01N33/4905 ,  G01N33/86

Abstract: Activated clotting time (ACT) tests detect blood clotting time based on the viscosity changes of a test sample, using a ferromagnetic washer lifted to the top of a test chamber and then dropped from the top via gravity; a drop time greater than a preset threshold value indicates clotting of the test sample. Blood samples which have high levels of heparin usually produce very weak clots that may easily be destroyed by the lifting movement of the washer. But if the clot threshold is set low to detect the weak clots, false detections occur during early testing cycles when activators are not fully suspended during the mixing cycle. Improved algorithms for lifting the washer and adjusting over time enable accurate detection of weak clots.

Abstract translation: 活化凝血时间（ACT）测试根据测试样品的粘度变化检测血液凝固时间，使用提升到测试室顶部的铁磁垫圈，然后通过重力从顶部滴落; 大于预设阈值的下降时间表示测试样品的凝血。 具有高水平肝素的血液样品通常产生非常弱的凝块，这可能容易被洗涤器的提升运动所破坏。 但是，如果凝块阈值设置为低以检测弱凝块，则在早期测试周期期间发生错误检测，当激活剂在混合循环期间未完全悬浮时。 用于提升洗衣机和随时间调整的改进的算法可以准确检测弱凝块。

公开(公告)号：US10379128B2

公开(公告)日：2019-08-13

申请号：US13868598

申请日：2013-04-23

Applicant: Medtronic, Inc.

Inventor： Charlene Yuan ,  Trevor Huang

IPC: G01N33/86 ,  G01N33/49

Abstract: Systems, apparatuses and methods include evaluation the clotting time or strength of clotting in the presence of various clot-affecting reagents to obtain a profile of clot analysis for determination of bleeding complications. The various reagents may be included in a single cartridge for use in a blood clotting analysis device.

公开(公告)号：US20180172665A1

公开(公告)日：2018-06-21

申请号：US15383995

申请日：2016-12-19

Applicant: Medtronic, Inc.

Inventor： Charlene Yuan ,  Trevor Huang ,  Tessy Kanayinkal

IPC: G01N33/49 ,  G01N15/05 ,  G01N27/74

CPC classification number: G01N33/4905 ,  G01N15/05

Abstract: A method carried out by a system configured to analyze blood. The method includes causing a ferromagnetic object to move in a chamber housing blood after clot initiation has been implicated. Movement of the object in the chamber is detected. The detected movement of the object is correlated with clot retraction of the blood. In some embodiments, the stop of detecting movement includes allowing the object to drop from a raised position and detecting a drop distance of the object. In related embodiments, the step of correlating detected movement with clot retraction includes reviewing a trace generated by a plurality of drop distances over time. In yet other embodiments, methods of the present disclosure can further including evaluating platelet function of the blood based upon assessed clot retraction.

公开(公告)号：US08921115B2

公开(公告)日：2014-12-30

申请号：US13788283

申请日：2013-03-07

Applicant: Medtronic, Inc.

Inventor： Charlene Yuan ,  Trevor Huang

IPC: G01N33/86 ,  G01N33/48

CPC classification number: G01N33/86 ,  G01N33/4905

Abstract: The invention includes systems, apparatuses and methods to evaluate the strength of clotting in addition to or separate from activated clotting time. The strength of clotting may be correlated with the amount of energy employed to move an object within blood. The strength of clotting may be correlated with the amount of time for fibrinolysis to occur. The strength of clotting may be determined by a system in which a ferromagnetic material is moved within blood.

Abstract translation: 本发明包括用于评估除活化凝血时间之外或与活化凝血时间分离的凝血强度的系统，装置和方法。 凝血的强度可能与在血液中移动物体所用的能量的量相关。 凝血的强度可能与发生纤维蛋白溶解的时间量相关。 凝血的强度可以通过其中铁磁材料在血液内移动的系统来确定。

公开(公告)号：US11275076B2

公开(公告)日：2022-03-15

申请号：US15383995

申请日：2016-12-19

Applicant: Medtronic, Inc.

Inventor： Charlene Yuan ,  Trevor Huang ,  Tessy Kanayinkal

IPC: G01N33/49 ,  G01N15/05

Abstract: A method carried out by a system configured to analyze blood. The method includes causing a ferromagnetic object to move in a chamber housing blood after clot initiation has been implicated. Movement of the object in the chamber is detected. The detected movement of the object is correlated with clot retraction of the blood. In some embodiments, the stop of detecting movement includes allowing the object to drop from a raised position and detecting a drop distance of the object. In related embodiments, the step of correlating detected movement with clot retraction includes reviewing a trace generated by a plurality of drop distances over time. In yet other embodiments, methods of the present disclosure can further including evaluating platelet function of the blood based upon assessed clot retraction.

公开(公告)号：US10371694B2

公开(公告)日：2019-08-06

申请号：US15135327

申请日：2016-04-21

Applicant: Medtronic, Inc.

Inventor： Daniel Cheek ,  Lawrence Erickson ,  Trevor Huang ,  Tessy Kanayinkal ,  Craig Petersen ,  Charlene Yuan

IPC: G01N33/49 ,  G01N33/86

Abstract: Activated clotting time (ACT) tests detect blood clotting time based on the viscosity changes of a test sample, using a ferromagnetic washer lifted to the top of a test chamber and then dropped from the top via gravity; a drop time greater than a preset threshold value indicates clotting of the test sample. Blood samples which have high levels of heparin usually produce very weak clots that may easily be destroyed by the lifting movement of the washer. But if the clot threshold is set low to detect the weak clots, false detections occur during early testing cycles when activators are not fully suspended during the mixing cycle. Improved algorithms for lifting the washer and adjusting over time enable accurate detection of weak clots.

公开(公告)号：US09429563B2

公开(公告)日：2016-08-30

申请号：US13706453

申请日：2012-12-06

Applicant: Medtronic, Inc.

Inventor： Daniel Cheek ,  Lawrence Erickson ,  Trevor Huang ,  Tessy Kanayinkal ,  Craig Petersen ,  Charlene Yuan

IPC: G01N33/49

CPC classification number: G01N33/4905 ,  G01N33/86

Abstract: Activated clotting time (ACT) tests detect blood clotting time based on the viscosity changes of a test sample, using a ferromagnetic washer lifted to the top of a test chamber and then dropped from the top via gravity; a drop time greater than a preset threshold value indicates clotting of the test sample. Blood samples which have high levels of heparin usually produce very weak clots that may easily be destroyed by the lifting movement of the washer. But if the clot threshold is set low to detect the weak clots, false detections occur during early testing cycles when activators are not fully suspended during the mixing cycle. Improved algorithms for lifting the washer and adjusting over time enable accurate detection of weak clots.

Abstract translation: 活化凝血时间（ACT）测试根据测试样品的粘度变化检测血液凝固时间，使用提升到测试室顶部的铁磁垫圈，然后通过重力从顶部滴落; 大于预设阈值的下降时间表示测试样品的凝血。 具有高水平肝素的血液样品通常产生非常弱的凝块，这可能容易被洗涤器的提升运动所破坏。 但是，如果凝块阈值设置为低以检测弱凝块，则在早期测试周期期间发生错误检测，当激活剂在混合循环期间未完全悬浮时。 用于提升洗衣机和随时间调整的改进的算法可以准确检测弱凝块。