公开(公告)号：US12089588B2

公开(公告)日：2024-09-17

申请号：US17400931

申请日：2021-08-12

Applicant: Biomatrica, Inc.

Inventor： Joel Desharnais ,  Victoria Arendt ,  Margrith Mattmann

IPC: A01N1/02 ,  G01N15/05 ,  G01N33/49

CPC classification number: A01N1/021 ,  G01N15/05 ,  G01N33/491

Abstract: The present invention relates to reduction of erythrocyte sedimentation rate in a blood sample. In particular, formulations, compositions, articles of manufacture, kits and methods for reduced erythrocyte sedimentation rate in a blood sample are provided.

公开(公告)号：US20230377144A1

公开(公告)日：2023-11-23

申请号：US18248553

申请日：2021-11-17

Applicant: SCOPIO LABS LTD.

Inventor： Ittai MADAR ,  Shahar KARNY ,  Eran SMALL ,  Erez NA'AMAN

IPC: G06T7/00 ,  G01N15/05

CPC classification number: G06T7/0012 ,  G01N15/05 ,  G06T2207/10056 ,  G06T2207/30024 ,  G06T2207/30242 ,  G01N2015/055

Abstract: A microscope system for detecting a scan area within hematology slides in digital microscopy may include a scanning apparatus to scan a hematology sample, and a processor coupled to the scanning apparatus and a memory. The processor may be configured to execute instructions which may cause the system to receive a first image of the sample at a first resolution and determine a scan area of the sample to scan in response to the first image. The instructions may further cause the system to scan the scan area to generate an image of the scan area at a second resolution greater than the first resolution and classify a plurality of cells from the image of the scan area into cell data comprising a plurality of cell parameters. The instructions may also cause the microscope system to output the cell data. Various other systems and methods are provided.

公开(公告)号：US10054531B2

公开(公告)日：2018-08-21

申请号：US14646562

申请日：2013-03-12

Applicant: MICROVISK LIMITED

Inventor： Richard John Dunn ,  Lois Bello Fernandez De Sanmamed ,  Robert Henry Ibbotson ,  Vladislav Djakov

IPC: G01N15/05 ,  G01N29/02 ,  G01N15/06 ,  G01N15/04 ,  G01N33/49 ,  G01N29/036

CPC classification number: G01N15/05 ,  G01N15/04 ,  G01N15/06 ,  G01N15/0606 ,  G01N29/022 ,  G01N29/036 ,  G01N33/491 ,  G01N2015/055

Abstract: There is provided a method of measuring a sedimentation parameter of suspensions or precipitants in a fluid medium sample, said method compromising providing at least one micro-cantilever sensor, said micro-cantilever sensor comprising at least two materials having different coefficients of thermal expansion, and having a heater and piezo-resistive sensor integrated therein, pulsing the heater with one or more electrical pulses to induce heat generation in the micro-cantilever, sampling the output of the integrated piezo-resistive sensor to characterize a response of the micro-cantilever during sedimentation in the fluid medium sample, and determining a value of the sedimentation parameter from the characterized response. There is also provided an apparatus arranged to carry out the method.

公开(公告)号：US20170227438A1

公开(公告)日：2017-08-10

申请号：US15503152

申请日：2015-08-03

Applicant: Fresenius Kabi Deutschland GmbH

Inventor： Frank Schmidt ,  Ilka Sternheimer ,  Artur Meisberger ,  Lars Michel

IPC: G01N15/05 ,  A61M1/36 ,  B01L3/00 ,  A61M1/02 ,  G01N29/024 ,  G01N29/22

CPC classification number: G01N15/05 ,  A61B5/14535 ,  A61B5/4836 ,  A61B2560/0437 ,  A61M1/0209 ,  A61M1/0259 ,  A61M1/0281 ,  A61M1/36 ,  A61M1/3609 ,  A61M1/361 ,  A61M1/3612 ,  A61M1/3632 ,  A61M1/3692 ,  A61M1/3693 ,  A61M2205/12 ,  A61M2205/121 ,  A61M2205/3313 ,  A61M2205/3368 ,  A61M2205/3375 ,  A61M2209/086 ,  A61M2230/207 ,  B01L3/502 ,  B01L2200/025 ,  B01L2300/0609 ,  B01L2300/0627 ,  B01L2300/0848 ,  B01L2300/0851 ,  G01N29/024 ,  G01N29/222 ,  G01N29/223 ,  G01N2015/0065 ,  G01N2015/0073 ,  G01N2015/0092 ,  G01N2015/055 ,  G01N2291/02466 ,  G01N2291/044

Abstract: A blood processing apparatus (1) comprises a measurement device (8) having at least one chamber element (80, 81) for receiving a blood fluid, wherein the at least one chamber element (80, 81) extends along a longitudinal axis (L) and comprises a circumferential wall (804, 814) extending about the longitudinal axis (L), a bottom wall (803, 813) and a top wall (805, 815) together defining a flow chamber (802, 812), the at last one chamber element (80, 81) further comprising an inlet port (800, 810) for allowing a flow of a blood fluid into the flow chamber (802, 812) and an outlet port (801, 811) for allowing a flow of a blood fluid out of the flow chamber (802, 812). The blood processing apparatus (1) further comprises a holder device (9) for holding the measurement device (8), the holder device (9) comprising a base (90) having a reception opening (900) for receiving the measurement device (8) and a closure element (91) movably arranged on the base (90) for locking the measurement device (8) in an inserted position in the reception opening (900). An ultrasonic sensor element (92, 93) of the holder device (9) is arranged on the base (90) and adapted to produce an ultrasonic sensor signal (P) for measuring a haematocrit value of a blood fluid in the flow chamber (802, 812). Herein, the ultrasonic sensor element (92, 93), in the inserted position of the measurement device (8), faces the bottom wall (803, 813) of the at least one chamber element (80, 81) for transmitting the ultrasonic signal (P) into the flow chamber (802, 812) through the bottom wall (803, 813). In this way a blood processing apparatus comprising a holder device for a measurement device is provided which allows to easily insert the measurement device into the holder device and allows for a reliable measurement of, in particular, a haematocrit value of a blood flow through the measurement device.

公开(公告)号：US09678088B2

公开(公告)日：2017-06-13

申请号：US14785980

申请日：2014-04-28

Applicant: President and Fellows of Harvard College ,  Children's Medical Center Corporation ,  The Brigham and Women's Hospital, Inc.

Inventor： George M. Whitesides ,  Ashok A. Kumar ,  Jonathan W. Hennek ,  Caeul Lim ,  Yovany Moreno ,  Charles R. Mace ,  Manoj T. Duraisingh ,  Matthew R. Patton ,  Si-yi Ryan Lee ,  Gaetana D'Alesio-Spina ,  Carlo Brugnara ,  Thomas P. Stossel

IPC: G01N33/49 ,  G01N33/80 ,  G01N15/05 ,  G01N15/00

CPC classification number: G01N33/80 ,  G01N15/05 ,  G01N33/491 ,  G01N2015/003 ,  G01N2015/0073 ,  G01N2015/0076 ,  G01N2800/22

Abstract: An aqueous multi-phase system for diagnosis of sickle cell disease is described, including two or more phase-separated phases including: a first aqueous phase including a first phase component and having a first density between about 1.025 g/cm3 and about 1.095 g/cm3; and a second aqueous phase including a second phase component and having a second density between about 1.100 g/cm3 and about 1.140 g/cm3; wherein the first density is lower than the second density; and each of the first and second phase components include at least one polymer.

公开(公告)号：US09498154B2

公开(公告)日：2016-11-22

申请号：US13636946

申请日：2010-12-28

Applicant: Nobuya Hashizume ,  Keishi Kitamura ,  Takahiro Nishimoto ,  Tomoaki Tsuda ,  Yuichi Kimura ,  Chie Seki ,  Iwao Kanno

Inventor： Nobuya Hashizume ,  Keishi Kitamura ,  Takahiro Nishimoto ,  Tomoaki Tsuda ,  Yuichi Kimura ,  Chie Seki ,  Iwao Kanno

IPC: A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  G01N15/04 ,  G01N15/05 ,  G01N33/49 ,  G01N21/07 ,  G01N21/64 ,  A61B5/15

CPC classification number: A61B5/1427 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150755 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  G01N15/042 ,  G01N15/05 ,  G01N21/07 ,  G01N21/6428 ,  G01N33/491 ,  G01N2015/045

Abstract: A boundary calculating unit is provided for determining boundaries between separated plasma and blood cell or air and plasma whose image is picked up by an image pickup unit. With such boundary calculating unit provided, the boundaries between the separated plasma and blood cell or air and plasma can be determined, and areas of the separated air, plasma, and blood cell can be determined accurately. Particularly, a straight line drawing unit is provided for drawing, on the image picked up, a plurality of straight lines parallel to grooves in a disk which performs plasma separation. The boundary calculating unit can easily determine the boundaries by determining the boundaries based on a profile of the plurality of straight lines drawn by the straight line drawing unit.

Abstract translation: 提供了一种边界计算单元，用于确定分离的等离子体与图像由图像拾取单元拾取的血细胞或空气和血浆之间的边界。 通过设置这样的边界计算单元，可以确定分离的血浆和血细胞或空气和血浆之间的边界，并且可以精确地确定分离的空气，血浆和血细胞的区域。 特别地，提供了直线描绘单元，用于在拍摄的图像上绘制平行于执行等离子体分离的盘中的凹槽的多条直线。 边界计算单元可以通过基于由直线描绘单元绘制的多条直线的轮廓确定边界来容易地确定边界。

公开(公告)号：US09494507B2

公开(公告)日：2016-11-15

申请号：US14418870

申请日：2013-07-19

Applicant: ALIFAX HOLDING SPA

Inventor： Paolo Galiano

IPC: G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  G01N15/05

CPC classification number: G01N15/05

Abstract: An apparatus to determine the blood sedimentation rate and other parameters connected thereto, carried out by emitting, by means of emitter means, a beam of radiations which passes through a sample being examined, and by detecting, by means of receiver means, the beam of radiations after they have passed through said sample, comprising a reading chamber associated to at least a tube connected to a feed of the sample to be analyzed. Said reading chamber is at least partly transparent to radiations in a certain range of wavelengths, and has at least a substantially rectilinear segment of reduced size into which the sample to be analyzed is introduced. The reading chamber consists of a tube made of plastic material, or glass, defining a capillary channel coupled to said tube in fluidic continuity.

Abstract translation: 一种用于确定血液沉降速率和与其连接的其它参数的装置，其通过发射装置发射通过被检查的样品的辐射束，并且通过接收装置检测到的光束 在它们通过所述样品之后的辐射，包括与至少连接到待分析样品的进料的管相连的读取室。 所述读取室对于在一定波长范围内的辐射至少部分透明，并且至少具有减小尺寸的基本上直线的，待分析样品被引入的片段。 阅读室由塑料材料或玻璃制成的管组成，其中限定了以流体连续性连接到所述管的毛细通道。

公开(公告)号：US20160136658A1

公开(公告)日：2016-05-19

申请号：US14887947

申请日：2015-10-20

Applicant: TRUSTEES OF BOSTON UNIVERSITY ,  FRAUNHOFER, USA, INC.

Inventor： Andre SHARON ,  Alexis SAUER-BUDGE ,  Aaron SIZE ,  Holger WIRZ

IPC: B04B11/04 ,  B01D21/26

CPC classification number: B04B11/04 ,  B01D21/262 ,  B01L3/502 ,  B04B5/0407 ,  B04B5/0421 ,  G01N1/2813 ,  G01N15/042 ,  G01N15/05 ,  G01N2035/00495

Abstract: The present invention relates to methods, devices and systems for separation and concentration of particles from liquid and fluid samples. In some embodiments, the separation/concentration is achieved by sequential centrifugation steps. In particular, one aspect of the invention relates to a separation/concentration device which comprises at least a first chamber and a second chamber connected by a first valve, whereby operation of the first valve controls the material transfer from the first chamber to the second chamber. In some embodiments, valve operation can be manually, semi-manually or automatically. Other aspects of the invention relate to single- or multi-chambered separation/concentrator devices, and methods and systems for use. Other aspects of the invention relate to devices for operation of the valves, e.g., semi-manual actuation devices, and automatic inertial activation devices and mechanical actuation devices present in purpose-built centrifuges.

Abstract translation: 本发明涉及用于从液体和液体样品中分离和浓缩颗粒的方法，装置和系统。 在一些实施方案中，通过连续离心步骤实现分离/浓缩。 特别地，本发明的一个方面涉及一种分离/浓缩装置，其包括至少第一室和通过第一阀连接的第二室，由此第一阀的操作控制材料从第一室转移到第二室 。 在一些实施例中，阀操作可以手动，半手动或自动。 本发明的其它方面涉及单室或多室分离/浓缩装置，以及使用的方法和系统。 本发明的其它方面涉及用于操作阀的装置，例如半手动致动装置，以及存在于专用离心机中的自动惯性激活装置和机械致动装置。

公开(公告)号：US20160124001A1

公开(公告)日：2016-05-05

申请号：US14785980

申请日：2014-04-28

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  CHILDREN'S MEDICAL CENTER CORPORATION

Inventor： George M. WHITESIDES ,  Ashok A. KUMAR ,  Jonathan W. HENNEK ,  Caeul LIM ,  Yovany MORENO ,  Charles R. MACE ,  Manoj T. DURAISINGH ,  Matthew R. PATTON ,  Ryan LEE ,  Gaetana D' ALESIO-SPINA ,  Carlo BRUGNARA

IPC: G01N33/80 ,  G01N15/05

CPC classification number: G01N33/80 ,  G01N15/05 ,  G01N33/491 ,  G01N2015/003 ,  G01N2015/0073 ,  G01N2015/0076 ,  G01N2800/22

Abstract: Multi-phase systems and kits using these multiphase systems are described. The Multi-phase system described herein comprises multiple phase-separated phases each comprises a phase component and the phases, taken together, represent a density gradient. The kit comprising the multiphase system as described herein may be used to separate biological analytes such as cells. Non-limiting examples of the biological analytes include normal erythrocyte with hemoglobin Hb AA, Hb CC, and Hb AS, sickle cell erythrocyte with hemoglobin Hb SS and Hb SC, reticulocyte, iron deficiency anemia red blood cell, β-thalessemia trait red blood cell, and normal red blood cell.

Abstract translation: 描述了使用这些多相系统的多相系统和套件。 本文所述的多相系统包括多个相分离相，每个相包括相分量，并且相位在一起表示密度梯度。 包含如本文所述的多相体系的试剂盒可用于分离生物分析物例如细胞。 生物分析物的非限制性实例包括具有血红蛋白Hb AA，Hb CC和Hb AS的正常红细胞，具有血红蛋白Hb SS和Hb SC的镰状细胞红细胞，网织红细胞，缺铁性贫血红细胞和红细胞性红细胞 细胞和正常红细胞。

公开(公告)号：US20160061825A1

公开(公告)日：2016-03-03

申请号：US14935655

申请日：2015-11-09

Applicant: Northwestern University

Inventor： Alan L. Buchman

IPC: G01N33/53 ,  G01N33/49 ,  G01N15/05

CPC classification number: G01N33/5308 ,  G01N15/05 ,  G01N33/492 ,  G01N33/6893 ,  G01N2015/055 ,  G01N2333/46 ,  G01N2333/4727 ,  G01N2333/4737 ,  G01N2333/765 ,  G01N2333/79 ,  G01N2333/805 ,  G01N2800/065 ,  G01N2800/50 ,  G01N2800/56

Abstract: Disclosed are methods for determining disease activity in a patient having or at risk for developing inflammatory bowel disease (IBD) which include measuring neopterin concentration in a fecal sample from the patient.

Abstract translation: 公开了用于确定患有或具有发展为炎性肠病（IBD）的风险的患者中的疾病活性的方法，其包括测量来自患者的粪便样品中的新蝶呤浓度。