公开(公告)号：US10058601B2

公开(公告)日：2018-08-28

申请号：US15594451

申请日：2017-05-12

Applicant: MERIAL, INC.

Inventor： Russell F. Bey ,  Paulraj Kirubakaran Lawrence ,  Randy R. Simonson

IPC: A61K39/02 ,  A61K49/00 ,  A61K39/00 ,  A61K39/102 ,  C07K14/285 ,  C12N1/36

CPC classification number: A61K39/102 ,  A61K2039/522 ,  A61K2039/543 ,  A61K2039/552 ,  A61K2039/70 ,  C07K14/285 ,  C12N1/36

Abstract: The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.

公开(公告)号：US20170246286A1

公开(公告)日：2017-08-31

申请号：US15594451

申请日：2017-05-12

Applicant: MERIAL INC.

Inventor： Russell F. Bey ,  Paulraj Kirubakaran Lawrence ,  Randy R. Simonson

IPC: A61K39/102 ,  C12N1/36 ,  C07K14/285

CPC classification number: A61K39/102 ,  A61K2039/522 ,  A61K2039/543 ,  A61K2039/552 ,  A61K2039/70 ,  C07K14/285 ,  C12N1/36

Abstract: The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.

公开(公告)号：US20180015157A1

公开(公告)日：2018-01-18

申请号：US15668946

申请日：2017-08-04

Applicant: MERIAL INC.

Inventor： Paulraj Kirubakaran Lawrence ,  Russell F. Bey ,  Randy R. Simonson

IPC: A61K39/102 ,  A61K39/12 ,  A61K39/135 ,  C12N7/00 ,  A61K39/00

CPC classification number: A61K39/102 ,  A61K39/12 ,  A61K39/135 ,  A61K2039/522 ,  A61K2039/552 ,  A61K2039/55588 ,  A61K2039/55594 ,  A61K2039/70 ,  C12N7/00 ,  C12N2760/00034 ,  C12N2770/32134

Abstract: The present invention provides attenuated P. multocida strains that elicit an immune response in animal P. multocida, compositions comprising said strains, methods of vaccination against P. multocida, and kits for use with such methods and compositions. The invention further provides novel, genetically-engineered mutations in P. multocida hyaD and nanPU genes, which are useful in the production of novel attenuated P. multocida bacterial strains.

公开(公告)号：US20160199477A1

公开(公告)日：2016-07-14

申请号：US14991003

申请日：2016-01-08

Applicant: Merial Inc.

Inventor： Russell F. Bey ,  Paulraj Kirubakaran Lawrence ,  Randy R. Simonson

IPC: A61K39/102

CPC classification number: A61K39/102 ,  A61K2039/522 ,  A61K2039/543 ,  A61K2039/552 ,  A61K2039/70 ,  C07K14/285 ,  C12N1/36

Abstract: The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.

Abstract translation: 本发明提供减毒的血液流行性感冒菌株，其在动物中引起血红蛋白溶血性免疫应答，包含所述菌株的组合物，针对血蓝单胞菌疫苗接种的方法，以及用于此类方法和组合物的试剂盒。 本发明还提供了多价疫苗，当以有效量向易感“运送发热”或牛呼吸道疾病的动物施用时提供保护性免疫。

公开(公告)号：US09675682B2

公开(公告)日：2017-06-13

申请号：US14991003

申请日：2016-01-08

Applicant: MERIAL INC.

Inventor： Russell F. Bey ,  Paulraj Kirubakaran Lawrence ,  Randy R. Simonson

IPC: A61K39/02 ,  A61K49/00 ,  A61K39/00 ,  A61K39/102 ,  C07K14/285 ,  C12N1/36

CPC classification number: A61K39/102 ,  A61K2039/522 ,  A61K2039/543 ,  A61K2039/552 ,  A61K2039/70 ,  C07K14/285 ,  C12N1/36

Abstract: The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.

公开(公告)号：US09370561B2

公开(公告)日：2016-06-21

申请号：US14075169

申请日：2013-11-08

Applicant: MERIAL INC.

Inventor： Russell F. Bey ,  Paulraj Kirubakaran Lawrence ,  Randy R. Simonson

IPC: A61K39/02 ,  A61K49/00 ,  A61K39/00 ,  A61K39/102 ,  C07K14/285 ,  C12N1/36

CPC classification number: A61K39/102 ,  A61K2039/522 ,  A61K2039/543 ,  A61K2039/552 ,  A61K2039/70 ,  C07K14/285 ,  C12N1/36

Abstract: The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.

Abstract translation: 本发明提供减毒的血液流行性感冒菌株，其在动物中引起血红蛋白溶血性免疫应答，包含所述菌株的组合物，针对血蓝单胞菌疫苗接种的方法，以及用于此类方法和组合物的试剂盒。 本发明还提供了多价疫苗，当以有效量向易感“运送发热”或牛呼吸道疾病的动物施用时提供保护性免疫。