公开(公告)号：US20200231940A1

公开(公告)日：2020-07-23

申请号：US16524645

申请日：2019-07-29

申请人： MERIAL INC. ,  GENZYME CORPORATION

发明人： Monica DIAS FIGUEIREDO ,  Sirkka RM KYOSTIO-MOORE ,  Patricia BERTHELETTE

IPC分类号： C12N7/00 ,  C12N15/86 ,  C12N9/10 ,  C07K14/78 ,  A61K48/00 ,  A61K38/45

摘要： The present disclosure relates to recombinant viral vectors, to pharmaceutical compositions comprising such recombinant vectors, and to methods for prevention and treatment of osteoarthritis in mammals. In particular, this disclosure provides adeno-associated virus (AAV) vectors capable of expressing, in a host, osteoprotective/chondroprotective bioactive proteins, including hyaluronan synthase 2 (HAS2) and lubricin (PRG4). Methods of production of these AAV are provided, as are methods of treatment of osteoarthritis in mammalian joints, by the long-term gene expression of osteoprotective/chondroprotective proteins, including HAS2 and PRG4, in both synovial and chondrocyte cells.

公开(公告)号：US10507545B2

公开(公告)日：2019-12-17

申请号：US15499127

申请日：2017-04-27

申请人： MERIAL INC.

发明人： Andy Brehm ,  Dennis Jerome Freeman ,  Ed Schindler ,  Julie Campbell

IPC分类号： B41M5/26 ,  B23K26/362 ,  B41M5/24 ,  B23K26/12 ,  B23K28/00 ,  B23K37/047 ,  A01N1/02 ,  B23K26/361

摘要： The invention relates to a machine for labeling “blank-labeled” cryogenically-frozen vials or ampoules, which contain heat-labile biological materials, and to which a laser-light sensitive material had been applied prior to freezing. Accordingly, the machine has been designed to maintain the integrity of the biological materials throughout all phases of the labeling process. The machine generally comprises a master control system; a programmable user interface; a frame; cryogenic freezer assemblies, for keeping the vials at the required low temperatures; an infeed assembly, configured to receive and position blank-labeled cryogenic vials; a cryostatic labeling/quality control tunnel, wherein the vials are maintained at the required temperature, labeled by laser ablation, and checked for quality; and, an outfeed assembly. The machine further comprises a means for transporting the vials from the infeed assembly to the tunnel, and from the tunnel to the outfeed assembly. Vials labeled according to the instant disclosure are ultimately manually or automatically loaded into cryogenic shipping containers.

公开(公告)号：US20190241625A1

公开(公告)日：2019-08-08

申请号：US16118857

申请日：2018-08-31

申请人： MERIAL INC.

发明人： Paulraj Lawrence

IPC分类号： C07K14/315 ,  A61K39/09 ,  A61K39/39

CPC分类号： C07K14/315 ,  A61K39/092 ,  A61K39/39 ,  A61K2039/552 ,  C12Q1/6869 ,  C40B40/08 ,  G16B30/00 ,  G16B50/00

摘要： The present invention provides S. suis strains that elicit an immune response in animal S. suis, compositions comprising said strains, methods of vaccination against S. suis, and kits for use with such methods and compositions. The invention further provides a comprehensive, unambiguous method of capsular typing based on whole genome sequencing and bioinformatics. This capsular typing approach can accurately identify serotypes even when strains possess novel capsular loci and can be used to determine which strains to include when formulating vaccines, including herd specific vaccines.

公开(公告)号：US20190105305A1

公开(公告)日：2019-04-11

申请号：US15936778

申请日：2018-03-27

申请人： MERIAL INC.

发明人： Mark David Soll ,  Diane Larsen ,  Susan Mancini Cady ,  Peter Cheifetz ,  Izabela Galeska ,  Saijun Gong

IPC分类号： A61K31/42 ,  A61K31/365 ,  A61K31/4985 ,  C07D261/04 ,  A61K45/06 ,  A23K20/00 ,  A61K47/42 ,  A61K31/325 ,  A01N43/80 ,  A61K31/194 ,  A61K47/44 ,  A61K47/36 ,  A61K47/32 ,  A61K47/14 ,  A61K9/00 ,  A61K47/12 ,  A61K47/10 ,  A61K31/437 ,  A61K31/27 ,  A61K31/7048

摘要： This invention relates to oral veterinary compositions for combating ectoparasites and endoparasites in animals, comprising at least one systemically-acting active agent in combination with a pharmaceutically acceptable carrier. This invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.

公开(公告)号：US20190000978A1

公开(公告)日：2019-01-03

申请号：US16125911

申请日：2018-09-10

申请人： Merial, Inc.

发明人： Noel Yves Henri Jean Genin

IPC分类号： A61K47/26 ,  A61K9/20 ,  A61K39/00 ,  A61K39/275 ,  A61K39/255 ,  A61K39/215 ,  A61K39/17 ,  A61K39/12 ,  A61K9/46 ,  A61K9/00

摘要： The present invention relates to novel stable compressed vaccine composition comprising least one anhydrous antigenic component comprising a stabilizer susceptible to foaming when the composition is mixed with liquid diluent; and an effective amount of a sugar alcohol.

公开(公告)号：US20190000965A1

公开(公告)日：2019-01-03

申请号：US16109570

申请日：2018-08-22

申请人： MERIAL, INC.

发明人： Frederic David ,  Zahia Hannas-Djebbara ,  Herve Poulet ,  Jules Maarten Minke

IPC分类号： A61K39/23

摘要： The present disclosure encompasses canine parvovirus (CPV) vaccines or compositions. The vaccine or composition may be a vaccine or composition containing CPV virus-like particle (VLP), and a preparation method and a use thereof. The CPV VLPs are formed by the CPV VP2 protein. Further, the disclosure broadly encompasses vaccines comprising combinations of MLV and VLP, which are capable of overcoming MDA against a variety of pathogens, which infect a variety of different species.

公开(公告)号：US20180344697A1

公开(公告)日：2018-12-06

申请号：US15777886

申请日：2016-11-16

申请人： MERIAL, INC.

发明人： Philippe Jeannin

IPC分类号： A61K31/415 ,  A61P33/14 ,  A61K9/00 ,  A61K47/22 ,  A61K47/10

CPC分类号： A01N47/02 ,  A01N25/02 ,  A01N25/30 ,  A01N43/40 ,  A01N49/00 ,  A61K31/415

摘要： The present invention relates to various topical veterinary compositions comprising fipronil, an insect growth regulator, and a veterinarily acceptable carrier.

公开(公告)号：US20180163230A1

公开(公告)日：2018-06-14

申请号：US15840764

申请日：2017-12-13

申请人： MERIAL, INC.

发明人： Michel Bublot ,  Teshome Mebatsion ,  Joyce Pritchard ,  Perry Linz ,  Aemro Kassa

IPC分类号： C12N15/869

CPC分类号： C12N15/869 ,  A61K39/12 ,  A61K39/155 ,  A61K39/245 ,  A61K39/295 ,  C07K14/03 ,  C07K14/08 ,  C12N7/00 ,  C12N2710/16311 ,  C12N2710/16334 ,  C12N2710/16343 ,  C12N2710/16363 ,  C12N2720/10034 ,  C12N2760/16163 ,  C12N2760/18134 ,  C12N2760/18163 ,  C12N2830/20 ,  C12N2830/50 ,  C12N2840/203

摘要： The present invention provides recombinant herpesvirus of turkeys (HVT) vectors that contain and express antigens of avian pathogens, compositions comprising the recombinant HVT vectors and polyvalent vaccines comprising the recombinant HVT vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant HVT vectors.

公开(公告)号：US20180085374A1

公开(公告)日：2018-03-29

申请号：US15726413

申请日：2017-10-06

申请人： MERIAL INC.

发明人： Rolf Valter Attstrom

IPC分类号： A61K31/5375 ,  A61Q11/00 ,  A61K8/49 ,  A61K45/06

CPC分类号： A61K31/5375 ,  A61K8/49 ,  A61K45/06 ,  A61K2300/00 ,  A61Q11/00

摘要： Use of a morpholino compound having the general formula (I) wherein R1 is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R2 is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group except in the alpha-position, or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the prevention or treatment of halitosis.

公开(公告)号：US20180059083A1

公开(公告)日：2018-03-01

申请号：US15686234

申请日：2017-08-25

申请人： MERIAL INC.

发明人： Christopher Davis Leslie

IPC分类号： G01N33/08 ,  G01N21/95 ,  G01N29/04 ,  G01N23/08 ,  B07C5/34 ,  A01K43/00 ,  B25J11/00 ,  B25J15/06

CPC分类号： G01N33/085 ,  A01K43/00 ,  A01K45/007 ,  B07C5/3416 ,  B07C2501/0081 ,  B25J11/0045 ,  B25J15/0616 ,  G01N21/951 ,  G01N23/06 ,  G01N29/04 ,  Y10S901/02

摘要： The invention relates to a candling apparatus for the rapid discrimination, removal and relocation of non-live avian eggs. The invention further relates to methods of use of the candling apparatus for the candling, removal and relocation of avian eggs.