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公开(公告)号：US20100048690A2
公开(公告)日：2010-02-25
申请号：US12304123
申请日：2007-06-15
申请人： Ma Jesus Martin Lopez , Laura Coello Molinero , Jose Fernando Reyes Benitez , Alberto Rodriguez Vicente , Maria Garranzo Garcia-Ibarrola , Carmen Murcia Perez , Andres Francesch Solloso , Francisco Sanchez Sancho , Maria del Carmen Cuevas Marchante , Rogelio Fernandez Rodriguez
发明人： Ma Jesus Martin Lopez , Laura Coello Molinero , Jose Fernando Reyes Benitez , Alberto Rodriguez Vicente , Maria Garranzo Garcia-Ibarrola , Carmen Murcia Perez , Andres Francesch Solloso , Francisco Sanchez Sancho , Maria del Carmen Cuevas Marchante , Rogelio Fernandez Rodriguez
IPC分类号： A61K31/351 , C07D309/30 , C12P17/06 , A61P35/00
CPC分类号： C07D309/32
摘要： Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus Lithoplocamia, species lithistoides, and derivatives thereof are provided.
摘要翻译： 提供了从茯苓，蔷薇科，落叶松属，物种listoistoides及其衍生物获得的抗肿瘤化合物。
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公开(公告)号：US20090186938A1
公开(公告)日：2009-07-23
申请号：US12304123
申请日：2007-06-15
申请人： Ma Jesus Martin Lopez , Laura Coello Molinero , Jose Fernando Reyes Benitez , Alberto Rodriguez Vicente , Maria Garranzo Garcia-Ibarrola , Carmen Murcia Perez , Andres Francesch Solloso , Francisco Sanchez Sancho , Maria del Carmen Cuevas Marchante , Rogelio Fernandez Rodriguez
发明人： Ma Jesus Martin Lopez , Laura Coello Molinero , Jose Fernando Reyes Benitez , Alberto Rodriguez Vicente , Maria Garranzo Garcia-Ibarrola , Carmen Murcia Perez , Andres Francesch Solloso , Francisco Sanchez Sancho , Maria del Carmen Cuevas Marchante , Rogelio Fernandez Rodriguez
IPC分类号： A61K31/351 , C07D309/30 , C12P17/06 , A61P35/00
CPC分类号： C07D309/32
摘要： Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus Lithoplocamia, species lithistoides, and derivatives thereof are provided.
摘要翻译： 提供了从茯苓，蔷薇科，落叶松属，物种listoistoides及其衍生物获得的抗肿瘤化合物。
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公开(公告)号：US20090030068A1
公开(公告)日：2009-01-29
申请号：US12097212
申请日：2006-12-14
申请人： Ma Jesus Martin Lopez , Jose Fernando Reyes Benitez , Rogelio Fernandez Rodriguez , Andres Francesch Solloso , Maria del Carmen Cuevas Marchante , Laura Coello Molinero
发明人： Ma Jesus Martin Lopez , Jose Fernando Reyes Benitez , Rogelio Fernandez Rodriguez , Andres Francesch Solloso , Maria del Carmen Cuevas Marchante , Laura Coello Molinero
IPC分类号： A61K31/335 , C07D323/00 , A61P35/00
CPC分类号： C07D493/18
摘要： The invention relates to novel antitumor compounds of general formula as well as their corresponding pharmaceutically acceptable salts, derivatives, prodrugs and stereoisomers. These compounds can be obtained by isolating a sponge from family Theonellidae, genus Theonella and species swinhoei, and forming derivatives from the isolated compounds. These compounds have cytotoxic activity and can be used for the treatment of the cancer.
摘要翻译： 本发明涉及通式的新型抗肿瘤化合物及其相应的药学上可接受的盐，衍生物，前药和立体异构体。 这些化合物可以通过从Theonellidae，Theonella属和swinhoei种分离海绵，并从分离的化合物形成衍生物获得。 这些化合物具有细胞毒性活性，可用于治疗癌症。
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公开(公告)号：US08501968B2
公开(公告)日：2013-08-06
申请号：US13171567
申请日：2011-06-29
申请人： Ma Jesús Martin López , Laura Coello Molinero , José Fernando Reyes Benítez , Alberto Rodríguez Vicente , María Garranzo García-Ibarrola , Carmen Murcia Pérez , Andrés Francesch Solloso , Francisco Sánchez Sancho , Maria del Carmen Cuevas Marchante , Rogelio Fernández Rodríguez
发明人： Ma Jesús Martin López , Laura Coello Molinero , José Fernando Reyes Benítez , Alberto Rodríguez Vicente , María Garranzo García-Ibarrola , Carmen Murcia Pérez , Andrés Francesch Solloso , Francisco Sánchez Sancho , Maria del Carmen Cuevas Marchante , Rogelio Fernández Rodríguez
IPC分类号： C07D309/30 , A01N43/16
CPC分类号： C07D309/32
摘要： Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus Lithoplocamia, species lithistoides, and derivatives thereof are provided.
摘要翻译： 提供了从茯苓，蔷薇科，落叶松属，物种listoistoides及其衍生物获得的抗肿瘤化合物。
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公开(公告)号：US20110237520A1
公开(公告)日：2011-09-29
申请号：US13133359
申请日：2009-12-18
申请人： Laura Coello Molinero , Rogelio Fernández Rodriguez , José Fernando Reyes Benitez , Andrés Francesch Solloso , Maria del Carmen Cuevas Marchante
发明人： Laura Coello Molinero , Rogelio Fernández Rodriguez , José Fernando Reyes Benitez , Andrés Francesch Solloso , Maria del Carmen Cuevas Marchante
CPC分类号： C07K7/02
摘要： Compounds of general formula I: wherein R1-R15 and n take permitted meanings for use in the treatment of cancer.
摘要翻译： 通式I的化合物：其中R1-R15和n具有用于治疗癌症的允许含义。
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公开(公告)号：US20120190870A1
公开(公告)日：2012-07-26
申请号：US13171567
申请日：2011-06-29
申请人： Ma Jesús Martín López , Laura Coello Molinero , José Fernando Reyes Benítez , Alberto Rodríguez Vicente , María Garranzo García- Ibarrola , Carmen Murcia Pérez , Andrés Francesch Solloso , Francisco Sánchez Sancho , María del Carmen Cuevas Marchante , Rogelio Fernández Rodríguez
发明人： Ma Jesús Martín López , Laura Coello Molinero , José Fernando Reyes Benítez , Alberto Rodríguez Vicente , María Garranzo García- Ibarrola , Carmen Murcia Pérez , Andrés Francesch Solloso , Francisco Sánchez Sancho , María del Carmen Cuevas Marchante , Rogelio Fernández Rodríguez
IPC分类号： C07D309/32 , C07F7/18 , C07C43/225
CPC分类号： C07D309/32
摘要： Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus Lithoplocamia, species lithistoides, and derivatives thereof are provided.
摘要翻译： 提供了从茯苓，蔷薇科，落叶松属，物种listoistoides及其衍生物获得的抗肿瘤化合物。
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公开(公告)号：US08324406B2
公开(公告)日：2012-12-04
申请号：US12304123
申请日：2007-06-15
申请人： Ma Jesús Martín López , Laura Coello Molinero , José Fernando Reyes Benítez , Alberto Rodríguez Vicente , María Garranzo García-Ibarrola , Carmen Murcia Pérez , Andrés Francesch Solloso , Francisco Sánchez Sancho , María del Carmen Cuevas Marchante , Rogelio Fernández Rodríguez
发明人： Ma Jesús Martín López , Laura Coello Molinero , José Fernando Reyes Benítez , Alberto Rodríguez Vicente , María Garranzo García-Ibarrola , Carmen Murcia Pérez , Andrés Francesch Solloso , Francisco Sánchez Sancho , María del Carmen Cuevas Marchante , Rogelio Fernández Rodríguez
IPC分类号： C07D309/30
CPC分类号： C07D309/32
摘要： Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus Lithoplocamia, species lithistoides, and derivatives thereof are provided.
摘要翻译： 提供了从茯苓，蔷薇科，落叶松属，物种listoistoides及其衍生物获得的抗肿瘤化合物。
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