公开(公告)号：US20090098140A1

公开(公告)日：2009-04-16

申请号：US12298761

申请日：2007-04-27

申请人： Markus Grompe ,  Philip R. Streeter ,  Craig Dorrell ,  Stephanie L. Abraham ,  Kelsea M. Lanxon-Cookson

发明人： Markus Grompe ,  Philip R. Streeter ,  Craig Dorrell ,  Stephanie L. Abraham ,  Kelsea M. Lanxon-Cookson

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N15/11 ,  G01N33/53 ,  G01N33/574 ,  C12N15/00 ,  C12N5/06

CPC分类号： C07K16/28 ,  G01N33/56966

摘要： Isolated monoclonal antibodies are disclosed herein that specifically bind a cell surface antigen expressed on the human pancreatic endocrine cells or a subset thereof, and/or a precursor thereof. Isolated monoclonal antibodies are also disclosed herein that specifically bind a cell surface antigen expressed on human pancreatic exocrine cells or human ductal cells. Humanized forms of these antibodies, and functional fragments of these antibodies, are also disclosed. The antibodies can be conjugated to an effector molecule, such as a detectable marker, a therapeutic agent, or a toxin. These antibodies are of use to detect and isolate pancreatic cells or a subset thereof. The antibodies can be used for in vitro or in vivo detection and/or isolation of pancreatic endocrine cells. Methods of treating a pancreatic tumor are also disclosed. In several examples, the isolated monoclonal antibodies bind pancreatic endocrine cells and can be used to detect diabetes or a pancreatic endocrine cell tumor.

摘要翻译： 本文公开了分离的单克隆抗体，其特异性结合在人胰腺内分泌细胞或其子集上表达的细胞表面抗原和/或其前体。 本文还公开了分离的单克隆抗体，其特异性结合在人胰腺外分泌细胞或人导管细胞上表达的细胞表面抗原。 还公开了这些抗体的人源化形式和这些抗体的功能片段。 抗体可以与效应分子缀合，例如可检测标记，治疗剂或毒素。 这些抗体可用于检测和分离胰腺细胞或其子集。 该抗体可用于胰腺内分泌细胞的体外或体内检测和/或分离。 还公开了治疗胰腺肿瘤的方法。 在几个实例中，分离的单克隆抗体结合胰腺内分泌细胞，可用于检测糖尿病或胰腺内分泌细胞肿瘤。

公开(公告)号：US08247186B2

公开(公告)日：2012-08-21

申请号：US13324929

申请日：2011-12-13

申请人： Markus Grompe ,  Philip R. Streeter ,  Craig Dorrell ,  Stephanie L. Abraham ,  Kelsea M. Shoop

发明人： Markus Grompe ,  Philip R. Streeter ,  Craig Dorrell ,  Stephanie L. Abraham ,  Kelsea M. Shoop

IPC分类号： G01N33/567

CPC分类号： C07K16/28 ,  G01N33/56966

摘要： Isolated monoclonal antibodies are disclosed herein that specifically bind a cell surface antigen expressed on the human pancreatic endocrine cells or a subset thereof, and/or a precursor thereof. Isolated monoclonal antibodies are also disclosed herein that specifically bind a cell surface antigen expressed on human pancreatic exocrine cells or human ductal cells. Humanized forms of these antibodies, and functional fragments of these antibodies, are also disclosed. The antibodies can be conjugated to an effector molecule, or a detectable marker. These antibodies are of use to detect and/or isolate pancreatic cells or a subset thereof. Methods of treating a pancreatic tumor are also disclosed.

摘要翻译： 本文公开了分离的单克隆抗体，其特异性结合在人胰腺内分泌细胞或其子集上表达的细胞表面抗原和/或其前体。 本文还公开了分离的单克隆抗体，其特异性结合在人胰腺外分泌细胞或人导管细胞上表达的细胞表面抗原。 还公开了这些抗体的人源化形式和这些抗体的功能片段。 抗体可以与效应分子或可检测标记缀合。 这些抗体可用于检测和/或分离胰腺细胞或其子集。 还公开了治疗胰腺肿瘤的方法。

公开(公告)号：US20120121512A1

公开(公告)日：2012-05-17

申请号：US13324929

申请日：2011-12-13

申请人： Markus Grompe ,  Philip R. Streeter ,  Craig Dorrell ,  Stephanie L. Abraham ,  Kelsea M. Shoop

发明人： Markus Grompe ,  Philip R. Streeter ,  Craig Dorrell ,  Stephanie L. Abraham ,  Kelsea M. Shoop

IPC分类号： C07K16/28 ,  C07K19/00 ,  C07H21/04 ,  A61K39/395 ,  A61K49/00 ,  A61P35/00 ,  C12N15/63 ,  C12N5/16 ,  G01N33/567 ,  C12N5/00 ,  C12N5/071 ,  C12N1/21 ,  C12N1/19 ,  C12N5/10 ,  C07K17/00

CPC分类号： C07K16/28 ,  G01N33/56966

摘要： Isolated monoclonal antibodies are disclosed herein that specifically bind a cell surface antigen expressed on the human pancreatic endocrine cells or a subset thereof, and/or a precursor thereof. Isolated monoclonal antibodies are also disclosed herein that specifically bind a cell surface antigen expressed on human pancreatic exocrine cells or human ductal cells. Humanized forms of these antibodies, and functional fragments of these antibodies, are also disclosed. The antibodies can be conjugated to an effector molecule, or a detectable marker. These antibodies are of use to detect and/or isolate pancreatic cells or a subset thereof. Methods of treating a pancreatic tumor are also disclosed.

摘要翻译： 本文公开了分离的单克隆抗体，其特异性结合在人胰腺内分泌细胞或其子集上表达的细胞表面抗原和/或其前体。 本文还公开了分离的单克隆抗体，其特异性结合在人胰腺外分泌细胞或人导管细胞上表达的细胞表面抗原。 还公开了这些抗体的人源化形式和这些抗体的功能片段。 抗体可以与效应分子或可检测标记缀合。 这些抗体可用于检测和/或分离胰腺细胞或其子集。 还公开了治疗胰腺肿瘤的方法。

公开(公告)号：US08097428B2

公开(公告)日：2012-01-17

申请号：US13010737

申请日：2011-01-20

申请人： Markus Grompe ,  Philip R. Streeter ,  Craig Dorrell ,  Stephanie L. Abraham ,  Kelsea M. Shoop

发明人： Markus Grompe ,  Philip R. Streeter ,  Craig Dorrell ,  Stephanie L. Abraham ,  Kelsea M. Shoop

IPC分类号： G01N33/567

CPC分类号： C07K16/28 ,  G01N33/56966

摘要： Isolated monoclonal antibodies are disclosed herein that specifically bind a cell surface antigen expressed on the human pancreatic endocrine cells or a subset thereof, and/or a precursor thereof. Isolated monoclonal antibodies are also disclosed herein that specifically bind a cell surface antigen expressed on human pancreatic exocrine cells or human ductal cells. Humanized forms of these antibodies, and functional fragments of these antibodies, are also disclosed. The antibodies can be conjugated to an effector molecule, such as a detectable marker, a therapeutic agent, or a toxin. These antibodies are of use to detect and isolate pancreatic cells or a subset thereof. The antibodies can be used for in vitro or in vivo detection and/or isolation of pancreatic endocrine cells. Methods of treating a pancreatic tumor are also disclosed. In several examples, the isolated monoclonal antibodies bind pancreatic endocrine cells and can be used to detect diabetes or a pancreatic endocrine cell tumor.

摘要翻译： 本文公开了分离的单克隆抗体，其特异性结合在人胰腺内分泌细胞或其子集上表达的细胞表面抗原和/或其前体。 本文还公开了分离的单克隆抗体，其特异性结合在人胰腺外分泌细胞或人导管细胞上表达的细胞表面抗原。 还公开了这些抗体的人源化形式和这些抗体的功能片段。 抗体可以与效应分子缀合，例如可检测标记，治疗剂或毒素。 这些抗体可用于检测和分离胰腺细胞或其子集。 该抗体可用于胰腺内分泌细胞的体外或体内检测和/或分离。 还公开了治疗胰腺肿瘤的方法。 在几个实例中，分离的单克隆抗体结合胰腺内分泌细胞，可用于检测糖尿病或胰腺内分泌细胞肿瘤。

公开(公告)号：US20110165080A1

公开(公告)日：2011-07-07

申请号：US13010737

申请日：2011-01-20

申请人： Markus Grompe ,  Philip R. Streeter ,  Craig Dorrell ,  Stephanie L. Abraham ,  Kelsea M. Shoop

发明人： Markus Grompe ,  Philip R. Streeter ,  Craig Dorrell ,  Stephanie L. Abraham ,  Kelsea M. Shoop

IPC分类号： C07K16/28 ,  C12N15/13 ,  C12N15/85 ,  C12N5/10 ,  C12N5/12 ,  G01N33/567 ,  C12N5/071 ,  A61K49/00

CPC分类号： C07K16/28 ,  G01N33/56966

摘要： Isolated monoclonal antibodies are disclosed herein that specifically bind a cell surface antigen expressed on the human pancreatic endocrine cells or a subset thereof, and/or a precursor thereof. Isolated monoclonal antibodies are also disclosed herein that specifically bind a cell surface antigen expressed on human pancreatic exocrine cells or human ductal cells. Humanized forms of these antibodies, and functional fragments of these antibodies, are also disclosed. The antibodies can be conjugated to an effector molecule, such as a detectable marker, a therapeutic agent, or a toxin. These antibodies are of use to detect and isolate pancreatic cells or a subset thereof. The antibodies can be used for in vitro or in vivo detection and/or isolation of pancreatic endocrine cells. Methods of treating a pancreatic tumor are also disclosed. In several examples, the isolated monoclonal antibodies bind pancreatic endocrine cells and can be used to detect diabetes or a pancreatic endocrine cell tumor.

摘要翻译： 本文公开了分离的单克隆抗体，其特异性结合在人胰腺内分泌细胞或其子集上表达的细胞表面抗原和/或其前体。 本文还公开了分离的单克隆抗体，其特异性结合在人胰腺外分泌细胞或人导管细胞上表达的细胞表面抗原。 还公开了这些抗体的人源化形式和这些抗体的功能片段。 抗体可以与效应分子缀合，例如可检测标记，治疗剂或毒素。 这些抗体可用于检测和分离胰腺细胞或其子集。 该抗体可用于胰腺内分泌细胞的体外或体内检测和/或分离。 还公开了治疗胰腺肿瘤的方法。 在几个实例中，分离的单克隆抗体结合胰腺内分泌细胞，可用于检测糖尿病或胰腺内分泌细胞肿瘤。

公开(公告)号：US07981628B2

公开(公告)日：2011-07-19

申请号：US12298761

申请日：2007-04-27

申请人： Markus Grompe ,  Philip R. Streeter ,  Craig Dorrell ,  Stephanie L. Abraham ,  Kelsea Shoop

发明人： Markus Grompe ,  Philip R. Streeter ,  Craig Dorrell ,  Stephanie L. Abraham ,  Kelsea Shoop

IPC分类号： G01N33/567

CPC分类号： C07K16/28 ,  G01N33/56966

摘要： Isolated monoclonal antibodies are disclosed herein that specifically bind a cell surface antigen expressed on the human pancreatic endocrine cells or a subset thereof, and/or a precursor thereof. Isolated monoclonal antibodies are also disclosed herein that specifically bind a cell surface antigen expressed on human pancreatic exocrine cells or human ductal cells. Humanized forms of these antibodies, and functional fragments of these antibodies, are also disclosed. The antibodies can be conjugated to an effector molecule, such as a detectable marker, a therapeutic agent, or a toxin. These antibodies are of use to detect and isolate pancreatic cells or a subset thereof. The antibodies can be used for in vitro or in vivo detection and/or isolation of pancreatic endocrine cells. Methods of treating a pancreatic tumor are also disclosed. In several examples, the isolated monoclonal antibodies bind pancreatic endocrine cells and can be used to detect diabetes or a pancreatic endocrine cell tumor.

摘要翻译： 本文公开了分离的单克隆抗体，其特异性结合在人胰腺内分泌细胞或其子集上表达的细胞表面抗原和/或其前体。 本文还公开了分离的单克隆抗体，其特异性结合在人胰腺外分泌细胞或人导管细胞上表达的细胞表面抗原。 还公开了这些抗体的人源化形式和这些抗体的功能片段。 抗体可以与效应分子缀合，例如可检测标记，治疗剂或毒素。 这些抗体可用于检测和分离胰腺细胞或其子集。 该抗体可用于胰腺内分泌细胞的体外或体内检测和/或分离。 还公开了治疗胰腺肿瘤的方法。 在几个实例中，分离的单克隆抗体结合胰腺内分泌细胞，可用于检测糖尿病或胰腺内分泌细胞肿瘤。