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    METHOD FOR DETERMINATION OF PROGRESSION RISK OF GLAUCOMA
    2.
    发明申请
    METHOD FOR DETERMINATION OF PROGRESSION RISK OF GLAUCOMA 有权
    用于确定GLAUCOMA进程风险的方法

    公开(公告)号：US20110207122A1

    公开(公告)日：2011-08-25

    申请号：US12596462

    申请日：2008-04-17

    申请人： Shigeru Kinoshita ,  Kei Tashiro ,  Masakazu Nakano ,  Tomohito Yagi ,  Kazuhiko Mori ,  Yoko Ikeda ,  Takazumi Taniguchi ,  Masaaki Kageyama

    发明人： Shigeru Kinoshita ,  Kei Tashiro ,  Masakazu Nakano ,  Tomohito Yagi ,  Kazuhiko Mori ,  Yoko Ikeda ,  Takazumi Taniguchi ,  Masaaki Kageyama

    IPC分类号： C12Q1/68 ,  C07H21/04

    CPC分类号： C12Q1/6886 ,  C12Q1/6883 ,  C12Q2600/156

    摘要： A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 752 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 752 (step B). According to the method of the present invention, the level of a progressive risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention in the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk.

    摘要翻译： 一种确定青光眼风险的存在或不存在的方法，包括以下步骤：在位于碱基序列的第31位的单核苷酸多态性的体外检测等位基因和/或基因型， 其中所述碱基序列是选自SEQ ID NO：203至752所示的碱基序列或其互补序列的至少一种碱基序列（步骤A），并比较检测到的等位基因和/或基因型 在SEQ ID NO：203〜752（步骤B）所示的碱基序列中具有含有高风险等位基因的等位基因和/或基因型中的至少一种的步骤A。 根据本发明的方法，可以通过分析样品中本发明的单核苷酸多态性的等位基因或基因型来确定样品供体中青光眼进行性风险的水平，使得样品供体可以 采取预防措施的青光眼，或者可以根据这种风险接受适当的治疗。

    Method for determination of progression risk of glaucoma
    3.
    发明授权
    Method for determination of progression risk of glaucoma 有权
    确定青光眼进展风险的方法

    公开(公告)号：US08431345B2

    公开(公告)日：2013-04-30

    申请号：US12596462

    申请日：2008-04-17

    申请人： Shigeru Kinoshita ,  Kei Tashiro ,  Masakazu Nakano ,  Tomohito Yagi ,  Kazuhiko Mori ,  Yoko Ikeda ,  Takazumi Taniguchi ,  Masaaki Kageyama

    发明人： Shigeru Kinoshita ,  Kei Tashiro ,  Masakazu Nakano ,  Tomohito Yagi ,  Kazuhiko Mori ,  Yoko Ikeda ,  Takazumi Taniguchi ,  Masaaki Kageyama

    IPC分类号： C12Q1/68 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C12Q1/6886 ,  C12Q1/6883 ,  C12Q2600/156

    摘要： A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 752 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 752 (step B). According to the method of the present invention, the level of a progressive risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention in the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk.

    摘要翻译： 一种确定青光眼风险的存在或不存在的方法，包括以下步骤：在位于碱基序列的第31位的单核苷酸多态性的体外检测等位基因和/或基因型， 其中所述碱基序列是选自SEQ ID NO：203至752所示的碱基序列或其互补序列的至少一种碱基序列（步骤A），并比较检测到的等位基因和/或基因型 在SEQ ID NO：203〜752（步骤B）所示的碱基序列中具有含有高风险等位基因的等位基因和/或基因型中的至少一种的步骤A。 根据本发明的方法，可以通过分析样品中本发明的单核苷酸多态性的等位基因或基因型来确定样品供体中青光眼进行性风险的水平，使得样品供体可以 采取预防措施的青光眼，或者可以根据这种风险接受适当的治疗。

    Protective Agent for Neuronal Cell Comprising Amidino Derivative as Active Ingredient
    4.
    发明申请
    Protective Agent for Neuronal Cell Comprising Amidino Derivative as Active Ingredient 审中-公开
    包含脒衍生物作为活性成分的神经元细胞的保护剂

    公开(公告)号：US20090088472A1

    公开(公告)日：2009-04-02

    申请号：US11920406

    申请日：2006-05-17

    申请人： Kouji Oohashi ,  Reina Doi ,  Masaaki Kageyama

    发明人： Kouji Oohashi ,  Reina Doi ,  Masaaki Kageyama

    IPC分类号： A61K31/24 ,  C07C229/54 ,  A61P27/02

    CPC分类号： C07D233/50 ,  A61K31/245 ,  A61K31/4168

    摘要： An object of the present invention is to provide a protective agent for a neuronal cell. The protective agent for a neuronal cell according to the present invention contains a compound represented by the following general formula [I] or a salt thereof as an active ingredient. In the formula, R1, R2 and R3 are the same or different and represent a hydrogen atom or an alkyl group, or R1 and R3 may be joined together to form a ring having one or more double bonds.

    摘要翻译： 本发明的目的是提供一种用于神经元细胞的保护剂。 本发明的神经元细胞保护剂含有下述通式[I]表示的化合物或其盐作为有效成分。 在该式中，R 1，R 2和R 3相同或不同，表示氢原子或烷基，或者R 1和R 3可以连接在一起形成具有一个或多个双键的环。

    Key switch with easily attachable key top
    5.
    发明授权
    Key switch with easily attachable key top 有权
    钥匙开关，易于安装的键顶

    公开(公告)号：US06483050B1

    公开(公告)日：2002-11-19

    申请号：US09696712

    申请日：2000-10-24

    申请人： Tsuyoshi Narusawa ,  Masaaki Kageyama

    发明人： Tsuyoshi Narusawa ,  Masaaki Kageyama

    IPC分类号： H01H1370

    CPC分类号： H01H3/125 ,  H01H2233/074

    摘要： A key switch includes an actuator for rotatably engaging the upper end of one of lever members, which constitute a cross-linked member, therewith and slidably engaging the upper end of the other lever member therewith. After the cross-linked member engaged with the actuator at its upper end is mounted on a membrane switch, the bottom of a key top is retained on the actuator by a simple means a as press fitting. This simplifies a molding die for the key top and facilitates an operation of attaching the key top.

    摘要翻译： 钥匙开关包括用于可旋转地接合构成交联构件的一个杠杆构件的上端的致动器，并且与另一个杠杆构件的上端可滑动地接合。 在与其上端的致动器接合的交联构件安装在薄膜开关上之后，通过简单的装置将键顶的底部保持在致动器上。 这简化了用于键顶的成型模具，并且有助于附接键顶的操作。

    Keyboard apparatus
    6.
    发明授权
    Keyboard apparatus 失效
    键盘装置

    公开(公告)号：US06312176B2

    公开(公告)日：2001-11-06

    申请号：US09283683

    申请日：1999-04-01

    申请人： Masaaki Kageyama ,  Shouji Suganami ,  Seiichi Suga ,  Tsuyoshi Narusawa ,  Teruyasu Fukuyama

    发明人： Masaaki Kageyama ,  Shouji Suganami ,  Seiichi Suga ,  Tsuyoshi Narusawa ,  Teruyasu Fukuyama

    IPC分类号： B41J508

    CPC分类号： H01H3/125

    摘要： A keyboard apparatus permits easier installation of slide retaining pins to a retaining portion and prevents intrusion of dust into the keyboard apparatus from the back surface of a supporting substrate thereof. A first retaining portion has a narrow area and a wide area, and slide retaining pins are latched in the wide area. A dust-proof sheet is provided on the bottom surface of a supporting substrate to cover through holes in the supporting substrate, the through holes resulting from the formation of the first retaining portion and second retaining portions.

    摘要翻译： 键盘装置允许容易地将滑动保持销安装到保持部分上，并防止灰尘从其支撑基板的背面侵入键盘装置。 第一保持部分具有窄的区域和宽的区域，并且滑动保持销锁定在广泛的区域中。 在支撑基板的底面上设有防尘片，以覆盖支撑基板上的通孔，形成第一保持部分和第二保持部分所产生的通孔。

    METHOD FOR DETERMINATION OF ONSET RISK OF GLAUCOMA
    7.
    发明申请
    METHOD FOR DETERMINATION OF ONSET RISK OF GLAUCOMA 审中-公开
    确定葡萄球菌风险的方法

    公开(公告)号：US20130012408A1

    公开(公告)日：2013-01-10

    申请号：US13546674

    申请日：2012-07-11

    申请人： Shigeru KINOSHITA ,  Kei Tashiro ,  Masakazu Nakano ,  Tomohito Yagi ,  Kazuhiko Mori ,  Yoko Ikeda ,  Takazumi Taniguchi ,  Masaaki Kageyama

    发明人： Shigeru KINOSHITA ,  Kei Tashiro ,  Masakazu Nakano ,  Tomohito Yagi ,  Kazuhiko Mori ,  Yoko Ikeda ,  Takazumi Taniguchi ,  Masaaki Kageyama

    IPC分类号： C40B30/04 ,  C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q1/6883 ,  C12Q2600/156

    摘要： A method of determining the presence or the absence of a glaucoma risk by detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism, comparing the allele and/or the genotype detected with at least one of an allele and/or a genotype with a high-risk allele, wherein the presence of a glaucoma risk is determined in a case where the allele detected is the high-risk allele, or the presence of a glaucoma risk is determined in a case where the genotype detected is a homozygote of the genotype comprising the high-risk allele or a heterozygote when the high-risk allele complies with a dominant genetic model, or the presence of a glaucoma risk is determined in a case where the genotype detected is a homozygote of the genotype comprising the high-risk allele when the high-risk allele complies with a recessive genetic model.

    摘要翻译： 通过体外检测单核苷酸多态性的等位基因和/或基因型来确定青光眼存在或不存在青光眼风险的方法，比较检测到的等位基因和/或基因型与等位基因和/或 具有高风险等位基因的基因型，其中在检测到的等位基因是高风险等位基因的情况下确定青光眼风险的存在，或者在检测到的基因型是纯合子的情况下确定青光眼风险的存在 在高风险等位基因符合显性遗传模型的情况下，包括高风险等位基因或杂合子的基因型的基因型，或者在检测到的基因型是包含高表达的基因型的纯合子的情况下，确定青光眼风险的存在 当高风险等位基因符合隐性遗传模型时，这种等位基因是错误的。

    METHOD FOR DETERMINATION OF ONSET RISK OF GLAUCOMA
    9.
    发明申请
    METHOD FOR DETERMINATION OF ONSET RISK OF GLAUCOMA 审中-公开
    确定葡萄球菌风险的方法

    公开(公告)号：US20100196895A1

    公开(公告)日：2010-08-05

    申请号：US12596258

    申请日：2008-04-17

    申请人： Shigeru Kinoshita ,  Kei Tashiro ,  Masakazu Nakano ,  Tomohito Yagi ,  Kazuhiko Mori ,  Yoko Ikeda ,  Takazumi Taniguchi ,  Masaaki Kageyama

    发明人： Shigeru Kinoshita ,  Kei Tashiro ,  Masakazu Nakano ,  Tomohito Yagi ,  Kazuhiko Mori ,  Yoko Ikeda ,  Takazumi Taniguchi ,  Masaaki Kageyama

    IPC分类号： C12Q1/68 ,  C07H21/04

    CPC分类号： C12Q1/6886 ,  C12Q1/6883 ,  C12Q2600/156

    摘要： A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 514 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 514 (step B). According to the method of the present invention, the level of an onset risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention on the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk.

    摘要翻译： 一种确定青光眼风险的存在或不存在的方法，包括以下步骤：在位于碱基序列的第31位的单核苷酸多态性的体外检测等位基因和/或基因型， 其中所述碱基序列是选自SEQ ID NO：203至514所示的碱基序列或其互补序列的至少一种碱基序列（步骤A），并比较检测到的等位基因和/或基因型 具有SEQ ID NO：203〜514（步骤B）所示的碱基序列中的含有高风险等位基因的等位基因和/或基因型中的至少一种的步骤A。 根据本发明的方法，可以通过对样品中的本发明中的单核苷酸多态性的等位基因或基因型进行分析来确定样品供体中的青光眼的发病风险水平，从而样品供体可以 采取预防措施的青光眼，或者可以根据这种风险接受适当的治疗。