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公开(公告)号：US08431345B2
公开(公告)日：2013-04-30
申请号：US12596462
申请日：2008-04-17
申请人： Shigeru Kinoshita , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
发明人： Shigeru Kinoshita , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/156
摘要： A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 752 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 752 (step B). According to the method of the present invention, the level of a progressive risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention in the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk.
摘要翻译： 一种确定青光眼风险的存在或不存在的方法，包括以下步骤：在位于碱基序列的第31位的单核苷酸多态性的体外检测等位基因和/或基因型， 其中所述碱基序列是选自SEQ ID NO：203至752所示的碱基序列或其互补序列的至少一种碱基序列（步骤A），并比较检测到的等位基因和/或基因型 在SEQ ID NO：203〜752（步骤B）所示的碱基序列中具有含有高风险等位基因的等位基因和/或基因型中的至少一种的步骤A。 根据本发明的方法，可以通过分析样品中本发明的单核苷酸多态性的等位基因或基因型来确定样品供体中青光眼进行性风险的水平，使得样品供体可以 采取预防措施的青光眼，或者可以根据这种风险接受适当的治疗。
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公开(公告)号：US20110207122A1
公开(公告)日：2011-08-25
申请号：US12596462
申请日：2008-04-17
申请人： Shigeru Kinoshita , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
发明人： Shigeru Kinoshita , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/156
摘要： A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 752 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 752 (step B). According to the method of the present invention, the level of a progressive risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention in the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk.
摘要翻译： 一种确定青光眼风险的存在或不存在的方法，包括以下步骤：在位于碱基序列的第31位的单核苷酸多态性的体外检测等位基因和/或基因型， 其中所述碱基序列是选自SEQ ID NO：203至752所示的碱基序列或其互补序列的至少一种碱基序列（步骤A），并比较检测到的等位基因和/或基因型 在SEQ ID NO：203〜752（步骤B）所示的碱基序列中具有含有高风险等位基因的等位基因和/或基因型中的至少一种的步骤A。 根据本发明的方法，可以通过分析样品中本发明的单核苷酸多态性的等位基因或基因型来确定样品供体中青光眼进行性风险的水平，使得样品供体可以 采取预防措施的青光眼，或者可以根据这种风险接受适当的治疗。
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公开(公告)号：US20130210668A1
公开(公告)日：2013-08-15
申请号：US13850453
申请日：2013-03-26
申请人： Shigeru KINOSHITA , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
发明人： Shigeru KINOSHITA , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/156
摘要： A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 752 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 752 (step B). According to the method of the present invention, the level of a progressive risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention in the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk.
摘要翻译： 一种确定青光眼风险的存在或不存在的方法，包括以下步骤：在位于碱基序列的第31位的单核苷酸多态性的体外检测等位基因和/或基因型， 其中所述碱基序列是选自SEQ ID NO：203至752所示的碱基序列或其互补序列的至少一种碱基序列（步骤A），并比较检测到的等位基因和/或基因型 在SEQ ID NO：203〜752（步骤B）所示的碱基序列中具有含有高风险等位基因的等位基因和/或基因型中的至少一种的步骤A。 根据本发明的方法，可以通过分析样品中本发明的单核苷酸多态性的等位基因或基因型来确定样品供体中青光眼进行性风险的水平，使得样品供体可以 采取预防措施的青光眼，或者可以根据这种风险接受适当的治疗。
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公开(公告)号：US20130012408A1
公开(公告)日：2013-01-10
申请号：US13546674
申请日：2012-07-11
申请人： Shigeru KINOSHITA , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
发明人： Shigeru KINOSHITA , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/156
摘要： A method of determining the presence or the absence of a glaucoma risk by detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism, comparing the allele and/or the genotype detected with at least one of an allele and/or a genotype with a high-risk allele, wherein the presence of a glaucoma risk is determined in a case where the allele detected is the high-risk allele, or the presence of a glaucoma risk is determined in a case where the genotype detected is a homozygote of the genotype comprising the high-risk allele or a heterozygote when the high-risk allele complies with a dominant genetic model, or the presence of a glaucoma risk is determined in a case where the genotype detected is a homozygote of the genotype comprising the high-risk allele when the high-risk allele complies with a recessive genetic model.
摘要翻译： 通过体外检测单核苷酸多态性的等位基因和/或基因型来确定青光眼存在或不存在青光眼风险的方法，比较检测到的等位基因和/或基因型与等位基因和/或 具有高风险等位基因的基因型，其中在检测到的等位基因是高风险等位基因的情况下确定青光眼风险的存在，或者在检测到的基因型是纯合子的情况下确定青光眼风险的存在 在高风险等位基因符合显性遗传模型的情况下，包括高风险等位基因或杂合子的基因型的基因型，或者在检测到的基因型是包含高表达的基因型的纯合子的情况下，确定青光眼风险的存在 当高风险等位基因符合隐性遗传模型时，这种等位基因是错误的。
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公开(公告)号：US20100196895A1
公开(公告)日：2010-08-05
申请号：US12596258
申请日：2008-04-17
申请人： Shigeru Kinoshita , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
发明人： Shigeru Kinoshita , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/156
摘要： A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 514 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 514 (step B). According to the method of the present invention, the level of an onset risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention on the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk.
摘要翻译： 一种确定青光眼风险的存在或不存在的方法，包括以下步骤：在位于碱基序列的第31位的单核苷酸多态性的体外检测等位基因和/或基因型， 其中所述碱基序列是选自SEQ ID NO：203至514所示的碱基序列或其互补序列的至少一种碱基序列（步骤A），并比较检测到的等位基因和/或基因型 具有SEQ ID NO：203〜514（步骤B）所示的碱基序列中的含有高风险等位基因的等位基因和/或基因型中的至少一种的步骤A。 根据本发明的方法，可以通过对样品中的本发明中的单核苷酸多态性的等位基因或基因型进行分析来确定样品供体中的青光眼的发病风险水平，从而样品供体可以 采取预防措施的青光眼，或者可以根据这种风险接受适当的治疗。
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6.发明申请Comprehensive Glaucoma Determination Method Utilizing Glaucoma Diagnosis Chip And Deformed Proteomics Cluster Analysis 审中-公开综合青光眼测定方法利用青光眼诊断芯片和变形蛋白质组学分析公开(公告)号：US20130275349A1
公开(公告)日：2013-10-17
申请号：US13976967
申请日：2011-12-28
申请人： Kei Tashiro , Shigeru Kinoshita , Tomohito Yagi , Masakazu Nakano , Kazuhiko Mori , Yoko Ikeda , Morio Ueno , Yuichi Tokuda , Katsumi Yagi , Kengo Yoshii , Masahiro Fuwa
发明人： Kei Tashiro , Shigeru Kinoshita , Tomohito Yagi , Masakazu Nakano , Kazuhiko Mori , Yoko Ikeda , Morio Ueno , Yuichi Tokuda , Katsumi Yagi , Kengo Yoshii , Masahiro Fuwa
IPC分类号： G06N99/00
CPC分类号： G06N20/00 , C12Q1/6886 , G16B20/00 , G16B25/00 , G16B40/00
摘要： Provided is a technique for determining a physiological attribute in a mammal, including the onset or progression of human glaucoma, with high accuracy. The results of the determination of genotype date and the results of the determination of cytokine date are consolidated by a consolidated determination unit (114); comparison is made for determining as to which is larger, the number of Case determination procedures or the number of control determination procedures (S330); and it is determined as Case (glaucoma) when the number of Case determination procedures is larger and it is determined as Control (normal person) when the number of Control determination procedures is larger.
摘要翻译： 提供了一种用于以高精度确定哺乳动物的生理属性，包括人类青光眼的发病或进展的技术。 确定基因型日期的结果和细胞因子日期的确定结果由综合确定单位（114）合并; 比较确定哪个更大，判定程序的数量或控制确定程序的数量（S330）; 当判定判定过程的数量较多并且当控制确定过程的数量较大时被确定为控制（普通人）时被确定为病例（青光眼）。
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公开(公告)号：US08432127B2
公开(公告)日：2013-04-30
申请号：US13240973
申请日：2011-09-22
IPC分类号： H02J7/00
CPC分类号： H01M2/1055 , H01M2/02 , H01M2/0202 , H01M2/0237 , H01M2/1066 , H01M2/30 , H01M10/42 , H01M10/46 , H01M2220/30
摘要： A battery charger includes a battery attachment section configured to have a rechargeable battery releasably attached thereto. The battery attachment section includes a flat attachment surface having a width corresponding to a width of a bottom surface of a case of the battery to be charged and a length greater than a length of the bottom surface of the case of the battery to be charged; a plurality of locking hooks provided on the attachment surface; a charger terminal configured to contact a terminal of the battery to be charged, the charger terminal including a plurality of plate-shaped contact pieces configured to be inserted into engaging grooves of the battery to be charged; and an attachment projection adjacent to the attachment surface and configured to secure the battery to the charger.
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公开(公告)号：US08411138B2
公开(公告)日：2013-04-02
申请号：US12787157
申请日：2010-05-25
IPC分类号： H04N7/18
CPC分类号： H04N5/23209 , H04N5/23203 , H04N2005/2255
摘要： According to an aspect of the present invention, there is provided a camera head separated type camera device including: a camera head; a camera control unit; and a cable connecting the camera head and the camera control unit with each other, wherein the camera control unit includes: a control portion which feeds a predetermined DC (Direct Current) voltage to the camera head, and wherein the camera head includes: an LVDS conversion driver portion which transmits an LVDS (Low Voltage Differential Signaling) signal to the camera control unit; a correction control portion which outputs a correction value for the LVDS signal; and an LVDS control portion which controls the LVDS conversion driver portion based on the correction value.
摘要翻译： 根据本发明的一个方面，提供了一种相机头分离型相机装置，包括：相机头; 相机控制单元; 以及将相机头和相机控制单元彼此连接的电缆，其中所述照相机控制单元包括：将预定DC（直流）电压馈送到所述相机头的控制部分，并且其中所述相机头包括：LVDS 转换驱动器部分，其向相机控制单元发送LVDS（低电压差分信号）信号; 校正控制部分，输出LVDS信号的校正值; 以及LVDS控制部分，其基于校正值来控制LVDS转换驱动器部分。
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公开(公告)号：US20120007548A1
公开(公告)日：2012-01-12
申请号：US13240973
申请日：2011-09-22
IPC分类号： H02J7/00
CPC分类号： H01M2/1055 , H01M2/02 , H01M2/0202 , H01M2/0237 , H01M2/1066 , H01M2/30 , H01M10/42 , H01M10/46 , H01M2220/30
摘要： A battery charger includes a battery attachment section configured to have a rechargeable battery releasably attached thereto. The battery attachment section includes a flat attachment surface having a width corresponding to a width of a bottom surface of a case of the battery to be charged and a length greater than a length of the bottom surface of the case of the battery to be charged; a plurality of locking hooks provided on the attachment surface; a charger terminal configured to contact a terminal of the battery to be charged, the charger terminal including a plurality of plate-shaped contact pieces configured to be inserted into engaging grooves of the battery to be charged; and an attachment projection adjacent to the attachment surface and configured to secure the battery to the charger.
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公开(公告)号：US20110115948A1
公开(公告)日：2011-05-19
申请号：US13010287
申请日：2011-01-20
申请人： Tatsuro Abe , Kuniaki Takahashi , Tatsuhiko Ikehata , Shiro Nagaoka , Kei Tashiro , Tsuyoshi Hagiwara
发明人： Tatsuro Abe , Kuniaki Takahashi , Tatsuhiko Ikehata , Shiro Nagaoka , Kei Tashiro , Tsuyoshi Hagiwara
IPC分类号： H04N5/262
CPC分类号： H04N5/23293 , H04N5/2628 , H04N5/765 , H04N5/772 , H04N5/781 , H04N5/907 , H04N5/91 , H04N9/79
摘要： An embodiment of a camera apparatus includes transferring a compressed playback streaming signal output from a recording medium to a map defined in a memory circuit, decoding the transferred playback streaming signal by a decoder, converting the decoded signal to a YUV signal in an image processing unit, transferring the converted signal to the map as a YUV signal, generating a magnified or reduced image from the YUV signal in the image processing unit, and storing the image on the map, overlaying a magnified or reduced image prepared on the map according to a magnified playback request, and outputting the overlaid image for seeking an output position.
摘要翻译： 相机装置的实施例包括将从记录介质输出的压缩播放流信号传送到存储电路中定义的映射，由解码器对传送的重放流信号进行解码，将解码信号转换成图像处理单元中的YUV信号 将转换的信号作为YUV信号传送到地图，从图像处理单元中的YUV信号生成放大或缩小的图像，并将该图像存储在地图上，根据图像处理在地图上重叠放大或缩小的图像 放大回放请求，并输出用于寻找输出位置的重叠图像。
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