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公开(公告)号：US08252565B2
公开(公告)日：2012-08-28
申请号：US12529716
申请日：2008-03-05
IPC分类号： C12P7/02
CPC分类号： C11B9/0053 , C12P7/22
摘要： The present invention relates to a method for production of a diol form represented by the formula (2), which includes filtering a culture fluid obtained by microbial conversion using a compound represented by the following formula (1a) and/or formula (1b) as a substrate, using a filter having an aperture size of 10 to 100 μm; washing the residue on the filter with water or a solvent having an SP value outside the range of 8.3 to 20 (cal/cm3)1/2; subsequently dissolving the obtained cake in a solvent having an SP value of 8.3 to 20 (cal/cm3)1/2; and then filtering or centrifuging the solution.According to the present invention, 1-(2-hydroxyethyl)-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol, which is useful as an intermediate for the production of 3a,6,6,9a-tetramethyldodecahydronaphtho[2,1-b]furan, can be efficiently produced at high purity.
摘要翻译： 本发明涉及一种由式（2）表示的二醇形式的制备方法，其包括使用下式（1a）和/或式（1b）表示的化合物将通过微生物转化获得的培养液过滤为 基板，使用孔径尺寸为10〜100μm的滤光器; 用水或SP值在8.3〜20（cal / cm3）1/2以下的溶剂洗涤过滤器上的残留物; 随后将得到的滤饼溶解在SP值为8.3〜20（cal / cm 3）1/2的溶剂中; 然后过滤或离心溶液。 根据本发明，可用作制备3a，6,6,9a-四甲基十二氢萘并[2,5-二氮杂萘基]的中间体的1-（2-羟乙基）-2,5,5,8a-四甲基十氢萘-2-醇， 1-b]呋喃可以高纯度地高效生产。
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公开(公告)号：US20100028964A1
公开(公告)日：2010-02-04
申请号：US12529716
申请日：2008-03-05
IPC分类号： C12P7/02
CPC分类号： C11B9/0053 , C12P7/22
摘要： The present invention relates to a method for production of a diol form represented by the formula (2), which includes filtering a culture fluid obtained by microbial conversion using a compound represented by the following formula (1a) and/or formula (1b) as a substrate, using a filter having an aperture size of 10 to 100 μm; washing the residue on the filter with water or a solvent having an SP value outside the range of 8.3 to 20 (cal/cm3)1/2; subsequently dissolving the obtained cake in a solvent having an SP value of 8.3 to 20 (cal/cm3)1/2; and then filtering or centrifuging the solution.According to the present invention, 1-(2-hydroxyethyl)-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol, which is useful as an intermediate for the production of 3a,6,6,9a-tetramethyldodecahydronaphtho[2,1-b]furan, can be efficiently produced at high purity.
摘要翻译： 本发明涉及一种由式（2）表示的二醇形式的制备方法，其包括使用下式（1a）和/或式（1b）表示的化合物将通过微生物转化获得的培养液过滤为 使用孔径为10〜100μm的滤光片的基板; 用水或SP值在8.3〜20（cal / cm3）1/2以下的溶剂洗涤过滤器上的残留物; 随后将得到的滤饼溶解在SP值为8.3〜20（cal / cm 3）1/2的溶剂中; 然后过滤或离心溶液。 根据本发明，可用作制备3a，6,6,9a-四甲基十二氢萘并[2,5-二氮杂萘基]的中间体的1-（2-羟乙基）-2,5,5,8a-四甲基十氢萘-2-醇， 1-b]呋喃可以高纯度地高效生产。
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公开(公告)号：US20120135484A1
公开(公告)日：2012-05-31
申请号：US13389422
申请日：2010-08-20
申请人： Saki Hamada , Shingo Koyama , Kazuhiro Onozuka , Takaaki Watanabe
发明人： Saki Hamada , Shingo Koyama , Kazuhiro Onozuka , Takaaki Watanabe
IPC分类号： C12P7/02
摘要： Disclosed is a method for producing 1-(2-hydroxyethyl) 2,5,5,8a-tetramethyldecahydronaphthalene-2-ol represented by formula (2), wherein microbial conversion is carried out using a compound(s) represented by formula (1a) and/or (1b) as a substrate, the resulting culture product, in which microorganisms obtained by the microbial conversion are contained, and a solvent having an SP value within the range of 7.5 to 9.0 [(cal/cm3)1/2] are mixed together, and subsequently the aqueous phase is removed therefrom.
摘要翻译： 公开了一种由式（2）表示的1-（2-羟乙基）2,5,5,8a-四甲基十氢萘-2-醇的制备方法，其中使用式（1a）表示的化合物进行微生物转化 ）和/或（1b）作为底物，所得到的含有通过微生物转化获得的微生物的培养物和SP值在7.5〜9.0的范围内的溶剂（[cal / cm 3] 1/2 ]混合在一起，随后从中除去水相。
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公开(公告)号：US20110306104A1
公开(公告)日：2011-12-15
申请号：US13202470
申请日：2010-02-10
申请人： Saki Hamada , Shingo Koyama , Kazuhiro Onozuka , Takaaki Watanabe
发明人： Saki Hamada , Shingo Koyama , Kazuhiro Onozuka , Takaaki Watanabe
IPC分类号： C12P7/02
CPC分类号： C12P7/22
摘要： Provided is a process for producing a diol, which can efficiently produce a diol having a low intensity of abnormal odor and high purity. A process for producing 1-(2-hydroxyethyl)-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol represented by formula (2): the process containing drying a culture fluid obtained by microbial conversion using a compound(s) represented by formula (1a) and/or (1b) as a substrate, bringing the dried product of the culture fluid into contact with such a solvent that the SP value of the medium obtainable after the contact between the dried product of the culture fluid and the solvent falls in the range of 9.5 to 16 [(cal/cm3)1/2], subsequently removing the microorganism from the medium, and crystallizing the medium.
摘要翻译： 本发明提供一种二醇的制造方法，其能够有效地制造异味高，纯度低的二醇。 由式（2）表示的1-（2-羟基乙基）-2,5,5,8a-四甲基十氢萘-2-醇的制备方法：使用所表示的化合物干燥通过微生物转化获得的培养液的方法 通过式（1a）和/或（1b）作为底物，将培养液的干燥产物与这样的溶剂接触，使培养液的干燥产物与培养液接触后可获得的培养基的SP值与 溶剂在9.5至16 [（cal / cm 3）1/2]的范围内，然后从培养基中除去微生物，并使培养基结晶。
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公开(公告)号：US08822186B2
公开(公告)日：2014-09-02
申请号：US13389422
申请日：2010-08-20
申请人： Saki Hamada , Shingo Koyama , Kazuhiro Onozuka , Takaaki Watanabe
发明人： Saki Hamada , Shingo Koyama , Kazuhiro Onozuka , Takaaki Watanabe
IPC分类号： C12P7/22
摘要： Disclosed is a method for producing 1-(2-hydroxyethyl)-2,5,5,8a-tetramethyldecahydronaphthalene-2-ol represented by formula (2), wherein microbial conversion is carried out using a compound(s) represented by formula (1a) and/or (1b) as a substrate, the resulting culture product, in which microorganisms obtained by the microbial conversion are contained, and a solvent having an SP value within the range of 7.5 to 9.0 [(cal/cm3)1/2] are mixed together, and subsequently the aqueous phase is removed therefrom.
摘要翻译： 公开了一种由式（2）表示的1-（2-羟基乙基）-2,5,5,8a-四甲基十氢萘-2-醇的制备方法，其中使用由式（2）表示的化合物进行微生物转化， 1a）和/或（1b）作为底物，所得到的微生物转化得到的微生物含有的培养物和SP值在7.5〜9.0的范围内的溶剂[（cal / cm 3）1 / 2]混合在一起，随后从其中除去水相。
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公开(公告)号：US20100198151A1
公开(公告)日：2010-08-05
申请号：US12670218
申请日：2007-10-31
CPC分类号： A61M5/326 , A61M5/28 , A61M5/3134 , A61M5/3202 , A61M5/50 , A61M2005/3103 , A61M2005/3128 , A61M2005/3247 , A61M2005/3267
摘要： A drug solution injector comprises a needle tube having a sharp needlepoint, a bottomed outer cylinder arranged on the base end side of the needle tube and having an inside space communicable with the inside of the needle tube, a gasket slidable within the outer cylinder, a drug solution in the space formed by the outer cylinder and the gasket, a support member supporting the needle tube and having a flow channel communicating with the inside of the needle tube, an operation mechanism permitting selection between a communicated state wherein the inside of the needle tube and the inside of the outer cylinder communicate with each other through the flow channel and a blocked state wherein the communication is blocked by rotating the support member, and an exposure preventer for preventing exposure of the needlepoint.
摘要翻译： 药液注射器包括具有尖锐针尖的针管，设置在针管的基端侧的底部外筒，并且具有与针管内部可连通的内部空间，可在外筒内滑动的垫圈， 由外筒和垫圈形成的空间中的药液，支撑针管并具有与针管内连通的流路的支撑构件，允许在连通状态之间进行选择的操作机构，其中针 管和外筒的内部通过流动通道彼此连通，并且阻止状态，其中通过旋转支撑构件阻止连通，以及用于防止针尖暴露的防暴剂。
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公开(公告)号：US08356629B2
公开(公告)日：2013-01-22
申请号：US12665145
申请日：2008-03-26
申请人： Shingo Koyama
发明人： Shingo Koyama
CPC分类号： F16K11/0856 , A61M5/007 , A61M39/223 , Y10T137/86566 , Y10T137/86871
摘要： A multiway cock has a cock body, a cock member, and a cover. The cock body has a circular tube part that has a first portion and a second portion arranged parallel to each other along the axis of the circular tube part. A first port and a second port are formed in the outer periphery of the first portion, and a third port, a fourth port, a fifth port, and a sixth port are formed in the outer periphery of the second portion. The cock member has a barrel part in which a first flow passage and a second flow passage are formed, a lever installation part, and a lever. Opening or closing of the first to sixth ports formed in the first portion and the second portion can be selected by rotating the cock member.
摘要翻译： 一个多路公鸡有一个公鸡身体，一个公鸡成员和一个封面。 旋塞体具有圆形管部，其具有沿着圆形管部的轴线彼此平行布置的第一部分和第二部分。 在第一部分的外周形成有第一端口和第二端口，在第二部分的外周形成有第三端口，第四端口，第五端口和第六端口。 旋塞构件具有形成第一流路和第二流路的筒部，杆安装部和杆。 可以通过旋转旋塞构件来选择形成在第一部分和第二部分中的第一至第六端口的打开或关闭。
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公开(公告)号：US20120168464A1
公开(公告)日：2012-07-05
申请号：US13395983
申请日：2011-03-02
申请人： Shingo Koyama
发明人： Shingo Koyama
IPC分类号： B67B1/00
CPC分类号： A61M5/28 , A61M5/347 , A61M5/5086 , A61M2005/3104 , A61M2005/312
摘要： A syringe includes a syringe outer tube having a spout and a spout-mounted cap. The cap has a cap main body sealing the spout in a liquid-tight manner, a mounting section mounted onto the spout, and a breakable breaking section linking the cap main body and the mounting section to release the link upon breaking. The inner circumferential portion of the mounting section includes protrusions inserted into a groove on the outer circumferential portion of the spout which also has a tilted section tilted relative to the axis of the spout outer circumferential portion. When the cap is rotated along the axial direction of the syringe outer tube, the protrusions move along the tilted section of the groove. The mounting section is thus displaced in the base end direction and the braking section is pulled in the direction and breaks to separate the cap main body from the mounting section.
摘要翻译： 注射器包括具有喷口和喷嘴安装盖的注射器外管。 盖具有以液密方式密封喷嘴的盖主体，安装在喷口上的安装部，以及连接盖主体和安装部的断裂部，以在断裂时释放连杆。 安装部的内周部具有插入到吐出口的外周部的槽内的突起，该突起也具有相对于喷口外周部的轴线倾斜的倾斜部。 当盖沿着注射器外管的轴向旋转时，突起沿着凹槽的倾斜部分移动。 因此，安装部分在基端方向上移位，并且制动部分沿着该方向被拉动并且使盖体主体与安装部分分离。
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公开(公告)号：US20090246851A1
公开(公告)日：2009-10-01
申请号：US12088152
申请日：2006-09-25
申请人： Hitoshi Sato , Yutaka Shoga , Shingo Koyama , Iyori Shirakura
发明人： Hitoshi Sato , Yutaka Shoga , Shingo Koyama , Iyori Shirakura
IPC分类号： C12N9/00
摘要： The present invention provides a process for producing an enzyme, which includes recovering an enzyme by microfiltering an enzyme-containing solution, having a cell density of 1% (v/v) or less and an enzyme concentration of 1% (w/v) or more in terms of the amount of proteins, with a cationic surfactant added in an amount of 0.01 to 1% (w/v) to the enzyme-containing solution.
摘要翻译： 本发明提供一种酶的制造方法，其包括通过微细化含有细胞密度为1％（v / v）以下，酶浓度为1％（w / v）的含酶溶液来回收酶， 或更多的蛋白质量，其中阳离子表面活性剂以0.01至1％（w / v）的量加入到含酶溶液中。
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公开(公告)号：US20070265580A1
公开(公告)日：2007-11-15
申请号：US11878143
申请日：2007-07-20
IPC分类号： A61M5/315
CPC分类号： A61M5/31555 , A61M5/3156 , A61M5/31563 , A61M5/3158 , A61M2005/31508
摘要： A syringe with which an accurate amount of a liquid can be discharged by a simple operation. The syringe 1 includes an outer tube 2, a gasket 3 slidable in the outer tube 2, a pusher 4 operable for moving the gasket 3, and a stopper 5 disposed to be slidable along the longitudinal direction of the pusher 4. The stopper 5 is fixed relative to the pusher 4 by the engagement of engaging portions, provided therein, with racks 47a, 47b formed on the pusher 4. When an operating portion 71 is depressed, the fixation condition is released, permitting regulation of the position of the stopper 5 on the pusher 4. When the depression on the operating portion 71 is canceled, the fixation condition is retained. When the pusher 4 is pressed in the tip end direction, a tip end face 66 of the stopper 5 comes into contact with a base end portion 28 of the outer tube 2, whereby the depth of insertion of the pusher 4 into the outer tube 2 is restricted, and a set amount of a chemical 100 is discharged through a diameter-reduced portion 22.
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