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    Process for the production of fruit polyphenols from unripe rosaceae fruit
    3.
    发明授权
    Process for the production of fruit polyphenols from unripe rosaceae fruit 失效
    从未成熟的玫瑰果科果实生产水果多酚的方法

    公开(公告)号：US5994413A

    公开(公告)日：1999-11-30

    申请号：US784546

    申请日：1997-01-21

    申请人： Masayuki Tanabe ,  Tomomasa Kanda ,  Akio Yanagida

    发明人： Masayuki Tanabe ,  Tomomasa Kanda ,  Akio Yanagida

    IPC分类号： A61K36/73 ,  A23L1/30 ,  A61K31/35 ,  A61K131/00 ,  A61P37/00 ,  A61P39/06 ,  C07D311/62 ,  A01N31/08

    CPC分类号： C07D311/62 ,  A23L33/105

    摘要： The present invention provides a fruit polyphenol obtained by subjecting unripe fruits of Rosaceae to pressing and/or extraction and then purifying the resulting juice or extract. The present invention further provides an antioxidant, a hypotensive agent, an antimutagenic agent, an antiallergic agent and an anticariogenic agent each comprising, as an effective component, a fruit polyphenol obtained by subjecting unripe fruits of Rosaceae to pressing and/or extraction and then purifying the resulting juice or extract. The fruit polyphenol of the present invention has various physiological activities, for example, an antioxidative activity, an ACE-inhibiting activity, an antimutagenic activity, a hyalulonidase-inhibiting activity and a GTase-inhibiting activity.

    摘要翻译： 本发明提供一种水果多酚，其通过使蔷薇科的未成熟果实压制和/或提取，然后纯化得到的果汁或提取物而获得。 本发明还提供抗氧化剂，降血压剂，抗诱变剂，抗过敏剂和抗龋剂，其各自包含通过使蔷薇科的未成熟果实压制和/或提取然后纯化而获得的水果多酚作为有效成分 所得的果汁或提取物。 本发明的果实多酚具有各种生理活性，例如抗氧化活性，ACE抑制活性，抗诱变活性，透明质酸酶抑制活性和GTase抑制活性。

    Process for purification of proanthocyanidin oligomer
    4.
    发明授权
    Process for purification of proanthocyanidin oligomer 失效
    纯化原花青素低聚物的方法

    公开(公告)号：US06800433B1

    公开(公告)日：2004-10-05

    申请号：US09959274

    申请日：2001-10-19

    申请人： Shinkichi Honda ,  Tomoya Takahashi ,  Ayako Kamimura ,  Takako Matsuoka ,  Tomomasa Kanda ,  Akio Yanagida ,  Kazuo Hieda

    发明人： Shinkichi Honda ,  Tomoya Takahashi ,  Ayako Kamimura ,  Takako Matsuoka ,  Tomomasa Kanda ,  Akio Yanagida ,  Kazuo Hieda

    IPC分类号： C12Q100

    CPC分类号： C07D311/62 ,  C07D311/60

    摘要： The present invention relates to a process for purifying dimeric to pentameric proanthocyanidin oligomers which comprises extracting the proanthocyanidin oligomers from raw materials containing the proanthocyanidin oligomers or crude purification products therefrom by solid-liquid extraction using methyl acetate as a liquid phase; a process for purifying dimeric to pentameric proanthocyanidin oligomers which comprises pretreating with an enzyme for hydrolysis raw materials containing the proanthocyanidin oligomers, crude purification products therefrom, or a solution containing one of these; and a process for purifying dimeric to pentameric proanthocyanidin oligomers with a uniform polymerization degree which comprises separating and purifying the proanthocyanidin oligomers by polymerization degree from raw materials containing the proanthocyanidin oligomers or crude purification products there from by normal phase silica gel liquid chromatography using as a mobile phase a single solvent or a mixed solvent of two or more solvents selected from the group consisting of an ester solvent, a ketone solvent, a hydrocarbon solvent, an ether solvent and an alcohol solvent.

    摘要翻译： 本发明涉及一种纯化二聚至五聚原花青素低聚物的方法，该方法包括通过使用乙酸甲酯作为液相通过固液萃取从原料中提取原花青素低聚物或粗提纯产物; 用于纯化二聚体至五聚原花青素低聚物的方法，其包括用酶预处理含有原花青素低聚物的水解原料，其粗提纯产物或含有这些之一的溶液; 以及具有均匀聚合度的二聚至五聚原花青素低聚物的纯化方法，该方法包括通过使用作为流动相的正相硅胶液相色谱法从含有原花青素低聚物或粗纯化产物的原料中分离纯化原花青素低聚物 将溶剂选自酯溶剂，酮溶剂，烃溶剂，醚溶剂和醇溶剂中的两种或更多种溶剂的单一溶剂或混合溶剂。