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    Hard capsules comprising polymers of vinyl esters and polyethers, their use and production
    2.
    发明授权
    Hard capsules comprising polymers of vinyl esters and polyethers, their use and production 失效
    包含乙烯基酯和聚醚的聚合物的硬胶囊，其使用和生产

    公开(公告)号：US06783770B2

    公开(公告)日：2004-08-31

    申请号：US09811542

    申请日：2001-03-20

    申请人： Maximilian Angel ,  Karl Kolter ,  Axel Sanner ,  Michael Gotsche

    发明人： Maximilian Angel ,  Karl Kolter ,  Axel Sanner ,  Michael Gotsche

    IPC分类号： A61K948

    CPC分类号： A61K9/4816 ,  C08F283/06 ,  C08F218/04

    摘要： The present invention relates to hard capsules comprising (A) polymers obtainable by free-radical polymerization of a) at least one vinyl ester in the presence of b) polyether-containing compounds and c) where appropriate one or more other copolymerizable monomers c) and subsequent at least partial hydrolysis of the ester functions in the original monomers a), with the proviso that in the absence of another copolymerizable monomer c) the polyether-containing compound b) must have a number average molecular weight ≦10,000, (B) where appropriate structure-improving auxiliaries and (C) other conventional shell constituents, the production and use thereof.

    摘要翻译： 本发明涉及硬胶囊，其包含（A）可通过自由基聚合获得的聚合物，a）至少一种乙烯基酯在存在b）含聚醚的化合物的存在下，和c）适当的一种或多种其它可共聚单体c） 在原始单体a）部分水解酯官能团，条件是在不存在另外的可共聚单体的情况下，c）含聚醚的化合物b）必须具有数均分子量<= 10,000，（B）其中适当的结构 改进助剂和（C）其他常规壳组分，其生产和使用。

    Preparing aqueous polymer dispersions
    3.
    发明授权
    Preparing aqueous polymer dispersions 失效
    制备聚合物水分散体

    公开(公告)号：US06444748B1

    公开(公告)日：2002-09-03

    申请号：US09456514

    申请日：1999-12-08

    申请人： Maximilian Angel ,  Karl Kolter ,  Axel Sanner

    发明人： Maximilian Angel ,  Karl Kolter ,  Axel Sanner

    IPC分类号： C08J2900

    CPC分类号： C08F220/14 ,  C08F2/22 ,  C08F220/18

    摘要： A process for preparing aqueous polymer dispersions by means of a polymerization, conducted in an aqueous system, of at least one free-radically polymerisable ethylenically unsaturated monomer in the presence of a polymerisation initiator, wherein the pH of the aqueous dispersion is adjusted during the preparation process by adding at least two different, basic reagents, at least one of said basic reagents being added in a plurality of stages.

    摘要翻译： 在聚合引发剂存在下，通过在水系统中进行至少一种可自由基聚合的烯属不饱和单体的聚合制备聚合物水分散体的方法，其中在制备过程中调节水分散体的pH 通过加入至少两种不同的碱性试剂，至少一种所述碱性试剂以多个阶段加入。

    Water-soluble or water-dispersible (co) polymers of hydroxyalkyl (meth) acrylates, a process for their preparation, and their use as coating agent, binder and/or film-forming excipient pharmaceutical dosage forms
    5.
    发明授权
    Water-soluble or water-dispersible (co) polymers of hydroxyalkyl (meth) acrylates, a process for their preparation, and their use as coating agent, binder and/or film-forming excipient pharmaceutical dosage forms 失效
    （甲基）丙烯酸羟烷基酯的水溶性或水分散性（共）聚合物，其制备方法及其作为包衣剂，粘合剂和/或成膜赋形剂药物剂型的用途

    公开(公告)号：US07049360B2

    公开(公告)日：2006-05-23

    申请号：US09964796

    申请日：2001-09-28

    申请人： Maximilian Angel ,  Axel Sanner ,  Karl Kolter

    发明人： Maximilian Angel ,  Axel Sanner ,  Karl Kolter

    IPC分类号： C08K3/20

    CPC分类号： A61K9/2846 ,  A61K9/2027 ,  C08F261/04

    摘要： The present invention relates to water-soluble or water-dispersible copolymers obtainable by free-radical polymerization of a) 80 to 20% by weight of hydroxy-C1–C6-alkyl (meth)acrylate and, where appropriate, one or more compounds of the formula (A) or (B) with R1=H, C1–C6-alkyl, R2=H, CH3 R3=C1–C24-alkyl or mixtures thereof in the presence of b) 20 to 80% by weight of polyvinyl alcohol (PVA) and c) where appropriate 0 to 20% by weight of other polymerizable compounds (C), a process for their preparation, and their use as coating agent, binder and/or film-forming excipient in pharmaceutical dosage forms.

    摘要翻译： 本发明涉及通过自由基聚合得到的水溶性或水分散性共聚物，该共聚物是a）80-20％（重量）的羟基-C 1 -C 6 - - （甲基）丙烯酸烷基酯和（如果合适的话）一种或多种式（A）或（B）的化合物，其中R 1 = H，C 1 -C C 1 -C 6烷基，R 2 = H，CH 3 3 R 3 = C 1〜 -C 24 - - - 烷基或其混合物，b）20-80％（重量）的聚乙烯醇（PVA）和c）适当时0-20％重量的其它可聚合化合物（C ），其制备方法，以及它们作为药物剂型中的包衣剂，粘合剂和/或成膜赋形剂的用途。

    Preparing aqueous polymer dispersions
    6.
    发明授权
    Preparing aqueous polymer dispersions 失效
    制备聚合物水分散体

    公开(公告)号：US06710122B2

    公开(公告)日：2004-03-23

    申请号：US10080906

    申请日：2002-02-25

    申请人： Maximilian Angel ,  Karl Kolter ,  Axel Sanner

    发明人： Maximilian Angel ,  Karl Kolter ,  Axel Sanner

    IPC分类号： C08F216

    CPC分类号： C08F220/14 ,  C08F2/22 ,  C08F220/18

    摘要： A process for preparing aqueous polymer dispersions by means of a polymerization, conducted in an aqueous system, of at least one free-radically polymerisable ethylenically unsaturated monomer in the presence of a polymerisation initiator, wherein the pH of the aqueous dispersion is adjusted during the preparation process by adding at least two different, basic reagents, at least one of said basic reagents being added in a plurality of stages.

    摘要翻译： 在聚合引发剂存在下，通过在水系统中进行至少一种可自由基聚合的烯属不饱和单体的聚合制备聚合物水分散体的方法，其中在制备过程中调节水分散体的pH 通过加入至少两种不同的碱性试剂，至少一种所述碱性试剂以多个阶段加入。

    Use of copolymers of monoethylenically unsaturated carboxylic acids as solubilizers
    7.
    发明授权
    Use of copolymers of monoethylenically unsaturated carboxylic acids as solubilizers 有权
    使用单烯属不饱和羧酸的共聚物作为增溶剂

    公开(公告)号：US06331294B1

    公开(公告)日：2001-12-18

    申请号：US09268720

    申请日：1999-03-17

    申请人： Helmut Meffert ,  Axel Sanner ,  Gunther Berndl ,  Folker Ruchatz ,  Karl Kolter ,  Kurt Heinz Bauer

    发明人： Helmut Meffert ,  Axel Sanner ,  Gunther Berndl ,  Folker Ruchatz ,  Karl Kolter ,  Kurt Heinz Bauer

    IPC分类号： A61K3174

    CPC分类号： A61K8/8158 ,  A61K8/8152 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/1075 ,  A61K9/2027 ,  A61K9/4866 ,  A61K47/32 ,  A61Q13/00 ,  A61Q17/04 ,  C08F220/04

    摘要： The invention relates to the use of copolymers comprising a) 82 to 99.9 mol % of at least one monoethylenically unsaturated C3-C8-carboxylic acid; b) 0.1 to 18 mol % of at least one monomer selected from the group b1) N—C8-C30-alkyl-substituted amides of monoethylenically unsaturated C3-C8-carboxylic acids, b2) N,N—C8-C30-dialkyl-substituted amides of monoethylenically unsaturated C3-C8-carboxylic acids, b3) C8-C30-alkyl esters of monoethylenically unsaturated C3-C8-carboxylic acids; c) 0 to 17.9 mol % of at least one monomer selected from the group of c1) vinyl esters of aliphatic C8-C30-carboxylic acids, c2) C8-C30-alkylvinyl ethers, mol % data for the individual components adding up to 100%, as solubilizer.

    摘要翻译： 本发明涉及包含a）82-99.9摩尔％的至少一种单烯属不饱和C 3 -C 8 - 羧酸的共聚物的用途; b）0.1至18摩尔％的至少一种选自b 1）N-C 8 -C 30 烷基取代的单烯属不饱和C3-C8-羧酸的酰胺，b2）单烯属不饱和C3-C8-羧酸的N，N-C8-C30-二烷基取代的酰胺，b3）单烯属不饱和的C 3 -C 30 - 烷基酯 C 3 -C 8 - 羧酸; c）0至17.9mol％的至少一种选自以下的单体：c1）脂肪族C 8 -C 30 - 羧酸的乙烯基酯，c 2）C 8 -C 30烷基乙烯基醚，mol％ 个别成分加起来可达100％，作为增溶剂。

    Use of copolymers of monoethylenically unsaturated carboxylic acids as solubilizers
    8.
    发明授权
    Use of copolymers of monoethylenically unsaturated carboxylic acids as solubilizers 有权
    使用单烯属不饱和羧酸的共聚物作为增溶剂

    公开(公告)号：US06497867B2

    公开(公告)日：2002-12-24

    申请号：US09953683

    申请日：2001-09-18

    申请人： Helmut Meffert ,  Axel Sanner ,  Gunther Berndl ,  Folker Ruchatz ,  Karl Kolter ,  Kurt Heinz Bauer

    发明人： Helmut Meffert ,  Axel Sanner ,  Gunther Berndl ,  Folker Ruchatz ,  Karl Kolter ,  Kurt Heinz Bauer

    IPC分类号： A61K3174

    CPC分类号： A61K8/8158 ,  A61K8/8152 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/1075 ,  A61K9/2027 ,  A61K9/4866 ,  A61K47/32 ,  A61Q13/00 ,  A61Q17/04 ,  C08F220/04

    摘要： The invention relates to the use of copolymers comprising a) 82 to 99.9 mol % of at least one monoethylenically unsaturated C3-C8-carboxylic acid; b) 0.1 to 18 mol % of at least one monomer selected from the group b1) N—C8-C30-alkyl-substituted amides of monoethylenically unsaturated C3-C8-carboxylic acids, b2) N,N—C8-C30-dialkyl-substituted amides of monoethylenically unsaturated C3-C8-carboxylic acids, b3) C8-C30-alkyl esters of monoethylenically unsaturated C3-C8-carboxylic acids; c) 0 to 17.9 mol % of at least one monomer selected from the group of c1) vinyl esters of aliphatic C8-C30-carboxylic acids, c2) C8-C30-alkylvinyl ethers, the mol % data for the individual components adding up to 100%, as solubilizer.

    摘要翻译： 本发明涉及包含a）82-99.9摩尔％的至少一种单烯属不饱和C 3 -C 8 - 羧酸的共聚物的用途; b）0.1至18摩尔％的至少一种选自b 1）N-C 8 -C 30 烷基取代的单烯属不饱和C3-C8-羧酸的酰胺，b2）单烯属不饱和C3-C8-羧酸的N，N-C8-C30-二烷基取代的酰胺，b3）单烯属不饱和的C 3 -C 30 - 烷基酯 C 3 -C 8 - 羧酸; c）0至17.9mol％的至少一种选自以下的单体：c1）脂族C 8 -C 30羧酸的乙烯基酯，c 2）C 8 -C 30烷基乙烯基醚，mol％数据为 各成分加起来可达100％，作为增溶剂。