公开(公告)号：US06331294B1

公开(公告)日：2001-12-18

申请号：US09268720

申请日：1999-03-17

申请人： Helmut Meffert ,  Axel Sanner ,  Gunther Berndl ,  Folker Ruchatz ,  Karl Kolter ,  Kurt Heinz Bauer

发明人： Helmut Meffert ,  Axel Sanner ,  Gunther Berndl ,  Folker Ruchatz ,  Karl Kolter ,  Kurt Heinz Bauer

IPC分类号： A61K3174

CPC分类号： A61K8/8158 ,  A61K8/8152 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/1075 ,  A61K9/2027 ,  A61K9/4866 ,  A61K47/32 ,  A61Q13/00 ,  A61Q17/04 ,  C08F220/04

摘要： The invention relates to the use of copolymers comprising a) 82 to 99.9 mol % of at least one monoethylenically unsaturated C3-C8-carboxylic acid; b) 0.1 to 18 mol % of at least one monomer selected from the group b1) N—C8-C30-alkyl-substituted amides of monoethylenically unsaturated C3-C8-carboxylic acids, b2) N,N—C8-C30-dialkyl-substituted amides of monoethylenically unsaturated C3-C8-carboxylic acids, b3) C8-C30-alkyl esters of monoethylenically unsaturated C3-C8-carboxylic acids; c) 0 to 17.9 mol % of at least one monomer selected from the group of c1) vinyl esters of aliphatic C8-C30-carboxylic acids, c2) C8-C30-alkylvinyl ethers, mol % data for the individual components adding up to 100%, as solubilizer.

摘要翻译： 本发明涉及包含a）82-99.9摩尔％的至少一种单烯属不饱和C 3 -C 8 - 羧酸的共聚物的用途; b）0.1至18摩尔％的至少一种选自b 1）N-C 8 -C 30 烷基取代的单烯属不饱和C3-C8-羧酸的酰胺，b2）单烯属不饱和C3-C8-羧酸的N，N-C8-C30-二烷基取代的酰胺，b3）单烯属不饱和的C 3 -C 30 - 烷基酯 C 3 -C 8 - 羧酸; c）0至17.9mol％的至少一种选自以下的单体：c1）脂肪族C 8 -C 30 - 羧酸的乙烯基酯，c 2）C 8 -C 30烷基乙烯基醚，mol％ 个别成分加起来可达100％，作为增溶剂。

公开(公告)号：US06497867B2

公开(公告)日：2002-12-24

申请号：US09953683

申请日：2001-09-18

申请人： Helmut Meffert ,  Axel Sanner ,  Gunther Berndl ,  Folker Ruchatz ,  Karl Kolter ,  Kurt Heinz Bauer

发明人： Helmut Meffert ,  Axel Sanner ,  Gunther Berndl ,  Folker Ruchatz ,  Karl Kolter ,  Kurt Heinz Bauer

IPC分类号： A61K3174

CPC分类号： A61K8/8158 ,  A61K8/8152 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/1075 ,  A61K9/2027 ,  A61K9/4866 ,  A61K47/32 ,  A61Q13/00 ,  A61Q17/04 ,  C08F220/04

摘要： The invention relates to the use of copolymers comprising a) 82 to 99.9 mol % of at least one monoethylenically unsaturated C3-C8-carboxylic acid; b) 0.1 to 18 mol % of at least one monomer selected from the group b1) N—C8-C30-alkyl-substituted amides of monoethylenically unsaturated C3-C8-carboxylic acids, b2) N,N—C8-C30-dialkyl-substituted amides of monoethylenically unsaturated C3-C8-carboxylic acids, b3) C8-C30-alkyl esters of monoethylenically unsaturated C3-C8-carboxylic acids; c) 0 to 17.9 mol % of at least one monomer selected from the group of c1) vinyl esters of aliphatic C8-C30-carboxylic acids, c2) C8-C30-alkylvinyl ethers, the mol % data for the individual components adding up to 100%, as solubilizer.

摘要翻译： 本发明涉及包含a）82-99.9摩尔％的至少一种单烯属不饱和C 3 -C 8 - 羧酸的共聚物的用途; b）0.1至18摩尔％的至少一种选自b 1）N-C 8 -C 30 烷基取代的单烯属不饱和C3-C8-羧酸的酰胺，b2）单烯属不饱和C3-C8-羧酸的N，N-C8-C30-二烷基取代的酰胺，b3）单烯属不饱和的C 3 -C 30 - 烷基酯 C 3 -C 8 - 羧酸; c）0至17.9mol％的至少一种选自以下的单体：c1）脂族C 8 -C 30羧酸的乙烯基酯，c 2）C 8 -C 30烷基乙烯基醚，mol％数据为 各成分加起来可达100％，作为增溶剂。

公开(公告)号：US06075107A

公开(公告)日：2000-06-13

申请号：US73856

申请日：1998-05-07

申请人： Stephan Kothrade ,  Helmut Meffert ,  Gunther Berndl ,  Axel Sanner ,  Stefan Stein ,  Volker Schehlmann ,  Folker Ruchatz

发明人： Stephan Kothrade ,  Helmut Meffert ,  Gunther Berndl ,  Axel Sanner ,  Stefan Stein ,  Volker Schehlmann ,  Folker Ruchatz

IPC分类号： A61K8/72 ,  A61K8/00 ,  A61K8/81 ,  A61K47/32 ,  A61Q19/00 ,  B01F17/32 ,  B01F17/52 ,  C08F226/10

CPC分类号： A61K47/32 ,  Y10S526/911

摘要： The use of copolymers ofA) 60-99 mol % of N-vinylpyrrolidone, andB) 1-40 mol % of a monomer selected from the group ofb1) C.sub.8 -C.sub.30 -alkyl esters of monoethylenically unsaturated C.sub.3 -C.sub.8 -carboxylic acids,b2) N-alkyl- or N,N-dialkyl-substituted amides of acrylic acid or of methacrylic acid with C.sub.8 -C.sub.18 -alkyl radicals, orb3) vinyl esters of aliphatic C.sub.8 -C.sub.30 -carboxylic acids, or mixtures of these monomers,as surface-active substances in preparations of water-insoluble substances.

摘要翻译： 使用A）60-99摩尔％的N-乙烯基吡咯烷酮和B）1-40摩尔％的选自b1）C8-C30-单烯属不饱和C3-C8-羧酸烷基酯的单体的共聚物 ，b2）丙烯酸或甲基丙烯酸与C8-C18-烷基的N-烷基 - 或N，N-二烷基取代的酰胺，或b3-脂肪族C 8 -C 30 - 羧酸的乙烯基酯，或这些单体的混合物 作为水不溶性物质制剂中的表面活性物质。

公开(公告)号：US06525156B1

公开(公告)日：2003-02-25

申请号：US09959402

申请日：2001-10-24

申请人： Andreas Ernst ,  Helmut Meffert ,  Axel Sanner ,  Stefan Stein ,  Folker Ruchatz

发明人： Andreas Ernst ,  Helmut Meffert ,  Axel Sanner ,  Stefan Stein ,  Folker Ruchatz

IPC分类号： C08F21206

CPC分类号： C08F212/04 ,  B01J20/26 ,  B01J39/20 ,  B01J41/14

摘要： Insoluble, only slightly swellable popcorn polymers containing a) from 50 to 99% by weight of styrene and/or at least one monounsaturated styrene derivative, b) from 0.1 to 40% by weight of at least one N-vinyllactam or N-vinylamine and c) from 0.1 to 10% by weight of at least one difunctional crosslinking component, the stated percentages by weight of the individual components a) to c) summing to 100%.

摘要翻译： 不溶性的仅有微膨胀的爆米花状聚合物，其含有50-99重量％的苯乙烯和/或至少一种单不饱和苯乙烯衍生物，b）0.1-40重量％的至少一种N-乙烯基内酰胺或N-乙烯基胺，和c） 0.1至10重量％的至少一种双官能交联组分，所述各组分a）至c）的所述重量百分数相加至100％。

公开(公告)号：US06528089B1

公开(公告)日：2003-03-04

申请号：US09555596

申请日：2000-05-31

申请人： Stephan Kothrade ,  Helmut Meffert ,  Gunther Berndl ,  Andreas Ernst ,  Axel Sanner

发明人： Stephan Kothrade ,  Helmut Meffert ,  Gunther Berndl ,  Andreas Ernst ,  Axel Sanner

IPC分类号： A61K920

CPC分类号： A61K31/421 ,  A23K20/10 ,  A23K40/10 ,  A23K40/20 ,  A23K40/25 ,  A23L27/74 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/2027 ,  A61K9/2095 ,  A61K31/277 ,  A23V2200/21 ,  A23V2250/30 ,  A23V2250/51088 ,  A23V2250/5118

摘要： Solid dosage forms are obtained by mixing at least one polymeric binder, at least one active ingredient, and, where appropriate, conventional additives to form a plastic mixture, and shaping, using as polymeric binder a copolymer of an N-vinyllactam and a copolymerizable monomer having a hydrophobic radical. Dosage forms which show slow release of the active ingredient are obtained in a simple and low-cost manner.

摘要翻译： 固体剂型是通过将至少一种聚合物粘合剂，至少一种活性成分和适当的常规添加剂混合以形成塑料混合物并且使用作为聚合物粘合剂的N-乙烯基内酰胺和可共聚单体的共聚物 具有疏水基团。 以简单且低成本的方式获得显示出缓慢释放活性成分的剂量形式。

公开(公告)号：US06436440B1

公开(公告)日：2002-08-20

申请号：US09283195

申请日：1999-04-01

申请人： Helmut Meffert ,  Folker Ruchatz

发明人： Helmut Meffert ,  Folker Ruchatz

IPC分类号： A61K914

CPC分类号： A61Q19/00 ,  A61K8/817 ,  A61K9/2027 ,  C08F226/06

摘要： The use of copolymers comprising a) 50 to 99% by weight of at least one N-vinyllactam or N-vinylamine selected from the group consisting of N-vinylpyrrolidone, N-vinylpiperidone, N-vinylcaprolactam, N-vinylimidazole and methylated N-vinylimidazole or N-vinylformamide and b) 1 to 50% by weight of at least one monomer selected from the group of b1) C14-C30-alkyl esters of monoethylenically unsaturated C3-C8-carboxylic acids; b2) N—C8-C30-alkyl-substituted amides of monoethylenically unsaturated C3-C8-carboxylic acids; b3) N,N—C8-C30-dialkyl-substituted amides of monoethylenically unsaturated C3-C8-carboxylic acids; b4) vinyl esters of aliphatic C8-C30-carboxylic acids; b5) C8-C30-alkyl vinyl ethers as matrix for producing solid pharmaceutical and cosmetic presentations.

摘要翻译： 包含a）50至99重量％的至少一种N-乙烯基内酰胺或N-乙烯胺的共聚物，其选自N-乙烯基吡咯烷酮，N-乙烯基哌啶酮，N-乙烯基己内酰胺，N-乙烯基咪唑和甲基化N-乙烯基咪唑，或 的1-乙烯基甲酰胺和b）1至50重量％的至少一种选自b1）单烯属不饱和C 3 -C 8 - 羧酸的C 14 -C 30烷基酯的单体; b2）N-C 8 -C 30烷基取代的酰胺 的单烯属不饱和C3-C8-羧酸; b3）单烯键式不饱和C3-C8-羧酸的N，N-C8-C30-二烷基取代的酰胺; b4）脂族C 8 -C 30 - 羧酸的乙烯基酯; b5）C8 用于制备固体药物和化妆品的-C30-烷基乙烯基醚基质。

公开(公告)号：US06271307B1

公开(公告)日：2001-08-07

申请号：US09283194

申请日：1999-04-01

申请人： Jürgen Huff ,  Helmut Meffert ,  Folker Ruchatz

发明人： Jürgen Huff ,  Helmut Meffert ,  Folker Ruchatz

IPC分类号： C08F29106

CPC分类号： A61Q13/00 ,  A61K8/91 ,  A61K9/0019 ,  A61K9/146 ,  A61K9/2031 ,  A61K9/4866 ,  A61K47/10 ,  A61K47/32 ,  A61Q17/04 ,  B01F17/0028 ,  B01F17/005

摘要： The use of graft copolymers obtainable by grafting a) polyalkylene oxides with b) at least one monomer selected from the group of b1) C1-C30-alkyl esters of monoethylenically unsaturated C3-C8-carboxylic acids; b2) vinyl esters of aliphatic C1-C30-carboxylic acids; b3) C1-C30-alkyl vinyl ethers; b4) N—C1-C12-alkyl-substituted amides of monoethylenically unsaturated C3-C8-carboxylic acids; b5) N,N—C1-C12-dialkyl-substituted amides of monoethylenically unsaturated C3-C8-carboxylic acids as solubilizer.

摘要翻译： 使用可通过接枝方法得到的接枝共聚物）b）至少一种选自b1）单烯属不饱和C 3 -C 8羧酸的C 1 -C 30烷基酯的单体; b2）脂族C 1 -C 30羧酸的乙烯基酯 酸; b3）C1-C30烷基乙烯基醚; b4）单烯属不饱和C 3 -C 8 - 羧酸的N-C 1 -C 12烷基取代的酰胺; b5）单烯属的N，N-C 1 -C 12 - 二烷基取代的酰胺 不饱和C3-C8-羧酸作为增溶剂。

公开(公告)号：US06284803B1

公开(公告)日：2001-09-04

申请号：US09395775

申请日：1999-09-14

申请人： Stephan Kothrade ,  Gunther Berndl ,  Helmut Meffert

发明人： Stephan Kothrade ,  Gunther Berndl ,  Helmut Meffert

IPC分类号： A61K4730

CPC分类号： A61K9/2027 ,  A61K9/2095

摘要： The present invention relates to a solid dosage form comprising at least one polymeric binder and at least one active ingredient and, where appropriate, conventional additives, wherein the polymeric binder consists of copolymerized units a) 15-83% by weight of at least one N-vinyllactam, b) 15-83% by weight of methyl methacrylate, c) 2-70% by weight of at least one other monomer and d) 0-9.9% by weight of at least one &agr;,&bgr;-ethylenically unsaturated acid.

摘要翻译： 本发明涉及包含至少一种聚合物粘合剂和至少一种活性成分以及适当的常规添加剂的固体剂型，其中聚合物粘合剂由共聚单元组成a）15-83重量％的至少一个N - 乙烯基内酰胺，b）15-83重量％的甲基丙烯酸甲酯，c）2-70重量％的至少一种其它单体，和d）0-9.9重量％的至少一种α，β-烯属不饱和酸。

公开(公告)号：US06736981B2

公开(公告)日：2004-05-18

申请号：US10076515

申请日：2002-02-19

申请人： Marcos Gomez ,  Tilman C Rock ,  Helmut Meffert ,  Axel Sanner

发明人： Marcos Gomez ,  Tilman C Rock ,  Helmut Meffert ,  Axel Sanner

IPC分类号： C02F100

CPC分类号： B01J20/261 ,  B01D37/02 ,  B01D39/02 ,  B01D39/16 ,  B01J20/26

摘要： The use is described of particulate, water-insoluble and scarcely swellable polymers of ethylenically unsaturated monomers, which polymers contain, copolymerized, at least 20% by weight, based on the total weight of the monomers, of at least one &agr;,&bgr;-monoethylenically unsaturated monocarboxylic acid having from 3 to 6 carbons as filter aid for filtering aqueous liquids. Subject-matter of the invention are also water-insoluble, scarcely swellable polymers (popcorn polymers) that contain, copolymerized, &agr;,&bgr;-monoethylenically unsaturated carboxylic acids and styrene or styrene derivatives, and also a process for their preparation.

摘要翻译： 该用途描述了烯属不饱和单体的颗粒状，水不溶性和几乎不溶胀的聚合物，该聚合物含有基于单体总重量至少20重量％的至少20重量％的至少一种α，β-单烯属 具有3至6个碳原子的不饱和一元羧酸作为过滤水性液体的助滤剂。 本发明的主题也是含有共聚的α，β-单烯属不饱和羧酸和苯乙烯或苯乙烯衍生物的水不溶性，几乎不溶胀的聚合物（爆米花聚合物），以及它们的制备方法。

公开(公告)号：US06939912B2

公开(公告)日：2005-09-06

申请号：US10150109

申请日：2002-05-20

申请人： Stephan Kothrade ,  Anton Negele ,  Helmut Meffert ,  Axel Sanner

发明人： Stephan Kothrade ,  Anton Negele ,  Helmut Meffert ,  Axel Sanner

IPC分类号： A61K47/32 ,  A01N25/10 ,  A61K8/72 ,  A61K8/81 ,  B01F17/00 ,  B01F17/52 ,  C08L39/00 ,  C08K39/00

CPC分类号： B01F17/005

摘要： Compositions comprising at least one water-insoluble ingredient and at least one copolymer of A) from 5 to 99% by weight of at least one N-vinylcarboxamide of the formula I where R1 and R2 independently of one another are hydrogen or C1-C6-alkyl; B) from 1 to 95% by weight of at least one monomer having a hydrophobic radical which can be copolymerized with vinylcarboxamides of the formula I; and optionally C) from 0 to 94% by weight of at least one other copolymerizable monomer, and the use of the above copolymers as solubility promoters.

摘要翻译： 包含至少一种水不溶性成分和至少一种共聚物的组合物，A至5重量％至99重量％的至少一种式I的N-乙烯基甲酰胺，其中R 1和R 2 2个彼此独立地是氢或C 1 -C 6 - 烷基; B）1至95重量％的至少一种具有疏水基团的单体，其可与式I的乙烯基酰胺共聚; 和任选的C）0至94重量％的至少一种其它可共聚单体，以及使用上述共聚物作为溶解促进剂。