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公开(公告)号：US12178603B2
公开(公告)日：2024-12-31
申请号：US17394355
申请日：2021-08-04
Applicant: Medtronic, Inc.
Inventor： Dwight E. Nelson , Jianping Wu , Rahul Gupta , Yan Zhao
Abstract: In some examples, a processor determines a patient state based on activity of a bioelectrical brain signal of a patient in one or more frequency sub-bands of a frequency band of interest. For example, a processor may determine a patient state based on the power level of a bioelectrical brain signal of the patient in one or more frequency sub-bands of a frequency band, or based on a spectral pattern of a bioelectrical brain signal in a frequency band, such as a shift in a power distribution between sub-bands, a change in the peak frequency within one or more sub-bands, a pattern of the power distribution over one or more frequency sub-bands, or a width or a variability of one or more sub-bands exhibiting a relatively high or low level of activity.
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公开(公告)号：US11213340B2
公开(公告)日：2022-01-04
申请号：US15130344
申请日：2016-04-15
Applicant: Medtronic, Inc.
Inventor： Xin Su , Dwight E. Nelson , Jason E. Agran
Abstract: In some examples, the disclosure describes devices, systems, and techniques for treating pain and/or pelvic floor dysfunction of a patient. For example, a method for treating pelvic floor dysfunction in a patient may include delivering, via a medical device, a therapy to one or more nerve fibers, wherein the therapy is configured to at least temporarily deactivate the one or more nerve fibers; and determining that the one or more nerve fibers was at least temporarily deactivated by delivering the therapy.
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公开(公告)号：US11202908B2
公开(公告)日：2021-12-21
申请号：US16730253
申请日：2019-12-30
Applicant: Medtronic, Inc.
Inventor： Xin Su , Dwight E. Nelson
Abstract: In some examples, electrical stimulation is delivered to a patient such that selective termination of the stimulation causes a therapeutic effect in the patient after termination of the electrical stimulation to the patient. The electrical stimulation may be insufficient to produce a desired therapeutic effect in the patient during stimulation, but sufficient to induce a post-stimulation desired therapeutic effect following termination of the stimulation. In some examples, the electrical stimulation may be sub-threshold electrical stimulation. In some examples, the desired therapeutic effect may alleviate bladder dysfunction, bowel dysfunction, or other disorders. The stimulation may be selectively terminated in response to one or more therapy trigger events to induce the post-stimulation therapeutic effect.
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公开(公告)号：US11116980B2
公开(公告)日：2021-09-14
申请号：US15946971
申请日：2018-04-06
Applicant: Medtronic, Inc.
Inventor： Dwight E. Nelson , Thaddeus S. Brink , Lance Zirpel
IPC: A61N1/36
Abstract: Techniques for delivering electrical stimulation therapy comprising a complex variation to at least one electrical stimulation parameter are described. In one example, processing circuitry of an implantable medical device (IMD) identifies a plurality of electrical stimulation parameters for at least one pulse train of electrical stimulation. The processing circuitry defines a complex variation to at least one electrical stimulation parameter of the plurality of electrical stimulation parameters. The processing circuitry modifies the at least one pulse train of electrical stimulation by introducing the complex variation to the electrical stimulation parameter function and controls a stimulation generator of the IMD to generate, as modified, the at least one pulse train of electrical stimulation.
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公开(公告)号：US11045649B2
公开(公告)日：2021-06-29
申请号：US15436287
申请日：2017-02-17
Applicant: Medtronic, Inc.
Inventor： Xuan K. Wei , Ryan D. Willemsen , Dwight E. Nelson , Sudha B. Iyer , Kira Stolen , Xin Su
Abstract: In some examples, a technique for delivering electrical stimulation therapy to a patient includes determining, by processing circuitry, one or more cycle settings associated with delivery of the electrical stimulation therapy, determining, by the processing circuitry, a cycle time period associated with each cycle setting, and delivering, by a medical device, electrical stimulation therapy based on the determined cycle settings and the determined cycle time periods. Each cycle setting may define an on-cycle, during which electrical stimulation is delivered, and an off-cycle, during which electrical stimulation is not delivered. The technique further may include delivering electrical stimulation to the patient to provide one or more reminders to the patient, such as a reminder to void or a reminder of the existence of electrical stimulation.
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Patent Agency Ranking
公开(公告)号：US20210001126A1
公开(公告)日：2021-01-07
申请号：US17028489
申请日：2020-09-22
Applicant: Medtronic, Inc.
Inventor： Jianping Wu , Dwight E. Nelson , Gabriela C. Molnar
Abstract: In some examples, a system may include a plurality of electrodes, electrical stimulation circuitry, and a controller. The controller may be configured to select one or more parameters of therapy to be delivered to a brain of a patient and to control the electrical stimulation circuitry to deliver the therapy to the brain of the patient based on the selected parameters and via a first one or more electrodes of the plurality of electrodes. The parameters may be defined based on a first plurality of electrical signals sensed at a plurality of different positions within the brain of the patient when electrical stimulation is not delivered at each of the positions and a second plurality of electrical signals sensed at each of the plurality of different positions within the brain of the patient in response to electrical stimulation delivered at each of the positions at a plurality of different intensities.
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公开(公告)号：US10456580B2
公开(公告)日：2019-10-29
申请号：US15256242
申请日：2016-09-02
Applicant: Medtronic, Inc.
Inventor： Thaddeus S. Brink , Dwight E. Nelson , Xin Su , Lance Zirpel
Abstract: Devices, systems, and methods may manage therapy delivery to a patient based on one or more physiological markers. In some examples, a method includes detecting a physiological marker that occurs prior in time to a dysfunctional phase of a physiological cycle, wherein a dysfunctional state of the physiological cycle occurs during the dysfunctional phase without treatment, responsive to detecting the physiological marker, initiating a first phase of the physiological cycle having a duration of time. The method may also include, responsive to the first phase elapsing, controlling a therapy delivery module to deliver neurostimulation therapy during a second phase that begins prior to the dysfunctional phase, wherein the neurostimulation therapy is configured to treat the dysfunctional state.
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公开(公告)号：US20180154144A1
公开(公告)日：2018-06-07
申请号：US15831986
申请日：2017-12-05
Applicant: Medtronic, Inc.
Inventor： Thaddeus S. Brink , Dwight E. Nelson , Lance Zirpel , Xin Su , Blake A. Hedstrom , Erik J. Peterson , David A. Dinsmoor
IPC: A61N1/36
Abstract: In general, techniques, methods, systems, and devices for delivering high frequency neurostimulation to control one or more pelvic disorders are described. In one example, a method includes identifying, by a medical device configured to be at least partially implanted in a patient, an indication to inhibit bladder activity. The medical device generates, in response to identifying the indication, electrical stimulation therapy comprising first electrical stimulation pulses comprising a first frequency greater than or equal to about 500 Hertz and less than or equal to about 5,000 Hertz. Further, the medical device delivers the electrical stimulation therapy to a target nerve selected from a group consisting of: a sacral nerve, a pelvic nerve, a tibial nerve, and a pudendal nerve of the patient.
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9.发明申请PATIENT STATE DETERMINATION BASED ON ONE OR MORE SPECTRAL CHARACTERISTICS OF A BIOELECTRICAL BRAIN SIGNAL 审中-公开基于生物电信号信号的一个或多个光谱特征的患者状态确定公开(公告)号：US20140358024A1
公开(公告)日：2014-12-04
申请号：US13955367
申请日：2013-07-31
Applicant: Medtronic, Inc.
Inventor： Dwight E. Nelson , Jianping Wu , Rahul Gupta , Yan Zhao
IPC: A61B5/04 , A61B5/0478 , A61B5/00 , A61N1/36
CPC classification number: A61B5/04014 , A61B5/048 , A61B5/4064 , A61B5/4833 , A61B5/7282 , A61N1/36139
Abstract: In some examples, a processor determines a patient state based on activity of a bioelectrical brain signal of a patient in one or more frequency sub-bands of a frequency band of interest. For example, a processor may determine a patient state based on the power level of a bioelectrical brain signal of the patient in one or more frequency sub-bands of a frequency band, or based on a spectral pattern of a bioelectrical brain signal in a frequency band, such as a shift in a power distribution between sub-bands, a change in the peak frequency within one or more sub-bands, a pattern of the power distribution over one or more frequency sub-bands, or a width or a variability of one or more sub-bands exhibiting a relatively high or low level of activity
Abstract translation: 在一些示例中，处理器基于感兴趣的频带的一个或多个频率子带中的患者的生物电脑信号的活动来确定患者状态。 例如，处理器可以基于频带的一个或多个频率子带中的患者的生物电脑信号的功率水平，或者基于频率的生物电脑信号的频谱图来确定患者状态 频带，例如子频带之间的功率分配的偏移，一个或多个子带内的峰值频率的变化，一个或多个频率子带上的功率分布的模式，或宽度或变化性 的一个或多个子带表现出相对较高或低水平的活性
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公开(公告)号：US12194301B2
公开(公告)日：2025-01-14
申请号：US17552813
申请日：2021-12-16
Applicant: Medtronic, Inc.
Inventor： Thaddeus S. Brink , Dwight E. Nelson , Xin Su , Lance Zirpel
Abstract: Devices, systems, and methods may manage therapy delivery to a patient based on one or more physiological markers. In some examples, a method includes detecting a physiological marker that occurs prior in time to a dysfunctional phase of a physiological cycle, wherein a dysfunctional state of the physiological cycle occurs during the dysfunctional phase without treatment, responsive to detecting the physiological marker, initiating a first phase of the physiological cycle having a duration of time. The method may also include, responsive to the first phase elapsing, controlling a therapy delivery module to deliver neurostimulation therapy during a second phase that begins prior to the dysfunctional phase, wherein the neurostimulation therapy is configured to treat the dysfunctional state.
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