公开(公告)号：US06770983B1

公开(公告)日：2004-08-03

申请号：US09961514

申请日：2001-09-22

申请人： Michael Cummins ,  Mario Magrone

发明人： Michael Cummins ,  Mario Magrone

IPC分类号： B60L114

CPC分类号： H02M3/155 ,  H02J1/14 ,  Y10T307/696 ,  Y10T307/702

摘要： An apparatus and method for delivering power from a D.C. voltage source to one or more D.C. loads rated at lower voltages. The invention provides for the repetitive application of the higher D.C. voltage to the loads for a predetermined time period sufficient for the load to operate yet not too long to ensure that the load will not be damaged. To implement the invention, a clock signal provides the time reference for separate slots allocated for the time periods associated with each of the loads. A user selectively enables or interrupts the repetitive connection to each of one of the loads. The rate of repetition of the connection of the high voltage source could vary from 60 to 200 Hertz, preferably without degrading the operation of typical loads.

摘要翻译： 一种用于将功率从直流电压源传递到以较低电压额定的一个或多个直流负载的装置和方法。 本发明提供了将较高的直流电压重复地施加到负载一段足以使负载工作的预定时间段，而不是太长以确保负载不会被损坏。 为了实现本发明，时钟信号为与每个负载相关联的时间段分配的单独时隙提供时间参考。 用户选择性地启用或中断与一个负载中的每一个的重复连接。 高压源连接的重复速率可以在60至200赫兹之间变化，优选地不降低典型负载的运行。

公开(公告)号：US09060755B2

公开(公告)日：2015-06-23

申请号：US13279330

申请日：2011-10-23

申请人： Naomi Buckley ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Micheal Moriarty ,  Karun D. Naga ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Ronan Wood ,  Lana Woolley ,  Denise Zarins ,  Mark S. Leung ,  Mark Gelfand ,  Barry Mullins

发明人： Naomi Buckley ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Micheal Moriarty ,  Karun D. Naga ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Ronan Wood ,  Lana Woolley ,  Denise Zarins ,  Mark S. Leung ,  Mark Gelfand ,  Barry Mullins

IPC分类号： A61B18/02 ,  A61B18/00

CPC分类号： A61B18/02 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2018/00023 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/0025 ,  A61B2018/00261 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B2018/0262

摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

摘要翻译： 本文公开了神经调节冷冻治疗装置及相关系统和方法。 根据本技术的特定实施例配置的冷冻治疗装置可以包括细长轴，其具有沿轴的至少一部分的远侧部分和供应内腔。 轴可以被配置为将远端部分血管内定位在肾动脉或肾口附近的治疗部位。 供应内腔可被配置为接收液体制冷剂。 冷冻治疗装置还可以包括在轴的远端处的冷却组件。 冷却组件可以包括与供应内腔流体连通的施加器，并且构造成当冷却组件处于展开状态时，将冷冻治疗冷却递送到靠近目标部位的神经。

公开(公告)号：US20120136418A1

公开(公告)日：2012-05-31

申请号：US13279328

申请日：2011-10-23

申请人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Seamus Ledwith ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

发明人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Seamus Ledwith ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

IPC分类号： A61F7/12

CPC分类号： A61B18/02 ,  A61B2018/00214 ,  A61B2018/00232 ,  A61B2018/00255 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/0212

摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

摘要翻译： 本文公开了神经调节冷冻治疗装置及相关系统和方法。 根据本技术的特定实施例配置的冷冻治疗装置可以包括细长轴，其具有沿轴的至少一部分的远侧部分和供应内腔。 轴可以被配置为将远端部分血管内定位在肾动脉或肾口附近的治疗部位。 供应内腔可被配置为接收液体制冷剂。 冷冻治疗装置还可以包括在轴的远端处的冷却组件。 冷却组件可以包括与供应内腔流体连通的施加器，并且构造成当冷却组件处于展开状态时，将冷冻治疗冷却递送到靠近目标部位的神经。

公开(公告)号：US4776231A

公开(公告)日：1988-10-11

申请号：US125737

申请日：1987-11-30

申请人： Michael Cummins ,  James M. Cummins ,  Raymond A. Theys

发明人： Michael Cummins ,  James M. Cummins ,  Raymond A. Theys

IPC分类号： B60R1/06 ,  B60R1/068 ,  F16C1/10

CPC分类号： F16C1/10 ,  B60R1/06 ,  B60R1/068 ,  Y10T74/20432

摘要： In an adjustable automobile mirror system of either the manual type or a three-cable operated type including a mirror anchored to a mirror retainer whose position is adjustable relative to a mirror housing, the improved mounting of the mirror retainer upon the mirror housing which comprises a part-spherical head upon the housing and a pivot block having a socket movably mounted upon the head. Resilient detents on the mirror retainer receive and retainingly engage the pivot block for movements therewith. One detent is manually yieldable to facilitate selective assembly of the mirror retainer on and disassembly from the pivot block.

摘要翻译： 在手动型或三电缆操作型的可调整的汽车镜系统中，包括镜子，其被固定到相对于镜子壳体可调节的镜保持器，反射镜保持器改进安装在镜子壳体上，其包括 部分球形头部位于壳体上，枢轴块具有可移动地安装在头部上的插座。 反射镜保持器上的弹性制动器接收并保持接合枢轴块以与其一起运动。 一个制动器是可手动的，以便于将镜保持器选择性地组装在枢轴块上并从枢轴块拆卸。

公开(公告)号：US20120277783A1

公开(公告)日：2012-11-01

申请号：US13097006

申请日：2011-04-28

申请人： Michael Cummins ,  Gerard Hession

发明人： Michael Cummins ,  Gerard Hession

IPC分类号： A61M29/02 ,  B29C43/18

CPC分类号： A61M25/104 ,  A61M2025/1075 ,  A61M2025/1084 ,  B29C43/18

摘要： A reinforced dilatation balloon, and a method of making, wherein the balloon includes a balloon body having a continuous polymer tube (e.g., generally cylindrical) having a proximal end, a distal end, and an external surface, and a tubular fiber reinforcing sleeve thermally bonded along the length of the sleeve to at least a portion of the external surface of the balloon body.

摘要翻译： 一种增强膨胀气球及其制造方法，其中气囊包括具有近端，远端和外表面的连续聚合物管（例如，大致圆柱形）的球囊体，以及管状纤维增强套管 沿着套筒的长度粘合到球囊体的外表面的至少一部分上。

公开(公告)号：US20120136417A1

公开(公告)日：2012-05-31

申请号：US13279327

申请日：2011-10-23

申请人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Seamus Ledwith ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Francesco Piccagli ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

发明人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Seamus Ledwith ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Francesco Piccagli ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

IPC分类号： A61F7/12

CPC分类号： A61B18/02 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2018/00023 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/0025 ,  A61B2018/00261 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B2018/0262

摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

公开(公告)号：US20120136344A1

公开(公告)日：2012-05-31

申请号：US13279321

申请日：2011-10-23

申请人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

发明人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2018/00023 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/0025 ,  A61B2018/00261 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B2018/0262

摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

公开(公告)号：US20070288359A1

公开(公告)日：2007-12-13

申请号：US11736820

申请日：2007-04-18

申请人： Susan Amadio ,  Theresa Breen ,  Steve Chan ,  Paula Christiaans ,  Carole Cooper ,  Michael Cummins ,  Greg Fedyk ,  Glen Giacomelli ,  Craig Kimber ,  Angela Nyhuis ,  Daniel Ostler ,  Ashish Pandita

发明人： Susan Amadio ,  Theresa Breen ,  Steve Chan ,  Paula Christiaans ,  Carole Cooper ,  Michael Cummins ,  Greg Fedyk ,  Glen Giacomelli ,  Craig Kimber ,  Angela Nyhuis ,  Daniel Ostler ,  Ashish Pandita

IPC分类号： G06Q40/00

CPC分类号： G06Q40/02 ,  G06Q40/025

摘要： Systems, methods, computer programming, and graphical user interfaces adapted for enabling creditors to provide prospective debtors with multiple credit opportunities and the ability to act on them, either separately or in various combinations. The credit opportunities may be identified using, in whole or in part, consideration of financial histories of the prospective debtors with the creditor making the plurality of credit offers, and/or the financial history(ies) of the prospective debtors with other creditors.

摘要翻译： 系统，方法，计算机程序设计和图形用户界面，适用于使债权人能够单独或以各种组合为潜在债务人提供多种信用机会和对其采取行动的能力。 信贷机会可以全部或部分地考虑到潜在债务人与债权人提供多种信用报价的财务历史，和/或潜在债务人与其他债权人的财务状况。

公开(公告)号：US08945107B2

公开(公告)日：2015-02-03

申请号：US13279327

申请日：2011-10-23

申请人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Seamus Ledwith ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Francesco Piccagli ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

发明人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Seamus Ledwith ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Francesco Piccagli ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

IPC分类号： A61B18/02 ,  A61B18/00

CPC分类号： A61B18/02 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2018/00023 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/0025 ,  A61B2018/00261 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B2018/0262

摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

公开(公告)号：US20120150267A1

公开(公告)日：2012-06-14

申请号：US13279330

申请日：2011-10-23

申请人： Naomi Buckley ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Micheal Moriarty ,  Karun D. Naga ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Ronan Wood ,  Lana Woolley ,  Denise Zarins ,  Mark S. Leung ,  Mark Gelfand ,  Barry Mullins

发明人： Naomi Buckley ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Micheal Moriarty ,  Karun D. Naga ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Ronan Wood ,  Lana Woolley ,  Denise Zarins ,  Mark S. Leung ,  Mark Gelfand ,  Barry Mullins

IPC分类号： A61F7/12

CPC分类号： A61B18/02 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2018/00023 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/0025 ,  A61B2018/00261 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B2018/0262

摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.