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公开(公告)号：US5756494A
公开(公告)日：1998-05-26
申请号：US456642
申请日：1995-06-02
申请人： Michael E. Lewis , James C. Kauer , Nicola Neff , Jill Roberts-Lewis , Chikara Murakata , Hiromitsu Saito , Yuzuru Matsuda , Marcie A. Glicksman , Fumihiko Kanai , Masami Kaneko
发明人： Michael E. Lewis , James C. Kauer , Nicola Neff , Jill Roberts-Lewis , Chikara Murakata , Hiromitsu Saito , Yuzuru Matsuda , Marcie A. Glicksman , Fumihiko Kanai , Masami Kaneko
IPC分类号： A61K31/40 , A61K31/407 , A61K31/41 , A61K31/415 , A61K31/44 , A61K31/505 , A61K31/5377 , A61K31/553 , A61K31/7056 , A61K38/22 , A61P9/00 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P31/18 , C07D487/14 , C07D498/22 , C07D519/00 , C07D498/12 , A61K31/55
CPC分类号： C07D487/14 , A61K31/407 , A61K31/5377 , A61K31/553 , A61K31/7056
摘要： The invention features novel derivatives of K-252a, as well as novel bis-N-substituted derivatives of staurosporine. The invention also features a method for treating diseased neuronal cells involving the administration of either the novel staurosporine derivatives or specified functional derivatives of K-252a.
摘要翻译： 本发明的特征在于K-252a的新衍生物以及星形孢菌素的新型双-N-取代衍生物。 本发明还涉及一种用于治疗患有神经元细胞的方法，涉及施用新型星形孢菌素衍生物或K-252a的特定功能衍生物。
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公开(公告)号：US5741808A
公开(公告)日：1998-04-21
申请号：US800383
申请日：1997-02-14
申请人： Michael E. Lewis , James C. Kauer , Nicola Neff , Jill Roberts-Lewis , Chikara Murakata , Hiromitsu Saito , Yuzuru Matsuda , Marcie A. Glicksman , Fumihiko Kanai , Masami Kaneko
发明人： Michael E. Lewis , James C. Kauer , Nicola Neff , Jill Roberts-Lewis , Chikara Murakata , Hiromitsu Saito , Yuzuru Matsuda , Marcie A. Glicksman , Fumihiko Kanai , Masami Kaneko
IPC分类号： A61K31/40 , A61K31/407 , A61K31/41 , A61K31/415 , A61K31/44 , A61K31/505 , A61K31/5377 , A61K31/553 , A61K31/7056 , A61K38/22 , A61P9/00 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P31/18 , C07D487/14 , C07D498/22 , C07D519/00 , A61K31/55
CPC分类号： C07D487/14 , A61K31/407 , A61K31/5377 , A61K31/553 , A61K31/7056
摘要： The invention features novel derivatives of K-252a, as well as novel bis-N-substituted derivatives of staurosporine. The invention also features a method for treating diseased neuronal cells involving the administration of either the novel staurosporine derivatives or specified functional derivatives of K-252a.
摘要翻译： 本发明的特征在于K-252a的新衍生物以及星形孢菌素的新型双-N-取代衍生物。 本发明还涉及一种用于治疗患有神经元细胞的方法，涉及施用新型星形孢菌素衍生物或K-252a的特定功能衍生物。
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公开(公告)号：US5621101A
公开(公告)日：1997-04-15
申请号：US486739
申请日：1995-06-07
申请人： Michael E. Lewis , James C. Kauer , Nicola Neff , Jill Roberts-Lewis , Chikara Murakata , Hiromitsu Saito , Yuzuru Matsuda , Marcie A. Glicksman , Fumihiko Kanai , Masami Kaneko
发明人： Michael E. Lewis , James C. Kauer , Nicola Neff , Jill Roberts-Lewis , Chikara Murakata , Hiromitsu Saito , Yuzuru Matsuda , Marcie A. Glicksman , Fumihiko Kanai , Masami Kaneko
IPC分类号： A61K31/407 , A61K31/5377 , A61K31/553 , A61K31/7056 , C07D487/14 , C07D498/22 , C07D519/00 , A61K31/55
CPC分类号： C07D487/14 , A61K31/407 , A61K31/5377 , A61K31/553 , A61K31/7056
摘要： The invention features novel derivatives of K-252a, as well as novel bis-N-substituted derivatives of staurosporine. The invention also features a method for treating diseased neuronal cells involving the administration of either the novel staurosporine derivatives or specified functional derivatives of K-252a.
摘要翻译： 本发明的特征在于K-252a的新衍生物以及星形孢菌素的新型双-N-取代衍生物。 本发明还涉及一种用于治疗患有神经元细胞的方法，涉及施用新型星形孢菌素衍生物或K-252a的特定功能衍生物。
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公开(公告)号：US5621100A
公开(公告)日：1997-04-15
申请号：US329540
申请日：1994-10-26
申请人： Michael E. Lewis , James C. Kauer , Nicola Neff , Jill Roberts-Lewis , Chikara Murakata , Hiromitsu Saito , Yuzuru Matsuda , Marcie A. Glicksman , Fumihiko Kanai , Masami Kaneko
发明人： Michael E. Lewis , James C. Kauer , Nicola Neff , Jill Roberts-Lewis , Chikara Murakata , Hiromitsu Saito , Yuzuru Matsuda , Marcie A. Glicksman , Fumihiko Kanai , Masami Kaneko
IPC分类号： A61K31/407 , A61K31/5377 , A61K31/553 , A61K31/7056 , C07D487/14 , C07D498/22 , C07D519/00 , A61K31/55
CPC分类号： C07D487/14 , A61K31/407 , A61K31/5377 , A61K31/553 , A61K31/7056
摘要： The invention features novel derivatives of K-252a, as well as novel bis-N-substituted derivatives of staurosporine. The invention also features a method for treating diseased neuronal cells involving the administration of either the novel staurosporine derivatives or specified functional derivatives of K-252a.
摘要翻译： 本发明的特征在于K-252a的新衍生物以及星形孢菌素的新型双-N-取代衍生物。 本发明还涉及一种用于治疗患有神经元细胞的方法，涉及施用新型星形孢菌素衍生物或K-252a的特定功能衍生物。
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5.发明授权
公开(公告)号：US5461146A
公开(公告)日：1995-10-24
申请号：US96561
申请日：1993-07-22
申请人： Michael E. Lewis , James C. Kauer , Nicola Neff , Jill Roberts-Lewis , Chikara Murakata , Hiromitsu Saito , Yuzuru Matsuda , Marcie A. Glicksman
发明人： Michael E. Lewis , James C. Kauer , Nicola Neff , Jill Roberts-Lewis , Chikara Murakata , Hiromitsu Saito , Yuzuru Matsuda , Marcie A. Glicksman
IPC分类号： A61K31/40 , A61K31/407 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/7056 , A61K38/22 , A61P9/10 , A61P21/04 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P31/18 , A61P43/00 , C07D487/14 , C07D498/22 , C07D519/00
CPC分类号： C07D487/14 , A61K31/407 , A61K31/5377 , A61K31/553 , A61K31/7056
摘要： The invention features novel derivatives of K-252a, as well as novel bis-N-substituted derivatives of staurosporine. Also, a method for treating diseased neuronal cells involving the administration of either the novel staurosporine derivatives or specified functional derivatives of K-252a.
摘要翻译： 本发明的特征在于K-252a的新衍生物以及星形孢菌素的新型双-N-取代衍生物。 另外，用于治疗患有神经元细胞的方法，涉及施用新型星形孢菌素衍生物或K-252a的特定功能衍生物。
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6.发明授权K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders 失效K-252a功能衍生物增强神经营养因子-3活性，用于治疗神经系统疾病
公开(公告)号：US5468872A
公开(公告)日：1995-11-21
申请号：US122893
申请日：1993-09-16
IPC分类号： C07D487/22 , A61K31/40 , A61K31/407 , A61K31/55 , A61P21/02 , A61P25/00 , A61P25/16 , A61P25/28 , C07D487/14 , C07D498/22 , C07D487/12
CPC分类号： C07D487/14 , A61K31/40 , A61K31/55
摘要： Functional K-252a derivatives are used to enhance trk phosphorylation and to potentiate the activity of neurotrophin-3 (NT-3). These compounds can be used to treat neurological disorders, alone or in combination with NT-3.
摘要翻译： 功能性K-252a衍生物用于增强trk磷酸化并增强神经营养因子-3（NT-3）的活性。 这些化合物可用于单独或与NT-3组合治疗神经障碍。
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7.发明授权Treating disorders by application of insulin-like growth factors and analogs 失效通过应用胰岛素样生长因子和类似物治疗疾病
公开(公告)号：US5776897A
公开(公告)日：1998-07-07
申请号：US823245
申请日：1997-03-24
申请人： Michael E. Lewis , James C. Kauer , Kevin R. Smith , Kathleen V. Callison , Frank Baldino , Nicola Neff , Mohamed Iqbal
发明人： Michael E. Lewis , James C. Kauer , Kevin R. Smith , Kathleen V. Callison , Frank Baldino , Nicola Neff , Mohamed Iqbal
摘要： A method of enhancing the survival of neuronal cells in a mammal, the cells being at risk of dying, the method comprising administering to the mammal an effective amount of one of the following substances: IGF-I; a functional derivative of IGF-I; IGF-II; a functional derivative of IGF-II; IGF-III; or a functional derivative of IGF-III.
摘要翻译： 一种增强哺乳动物神经元细胞存活的方法，所述细胞处于死亡的危险之中，该方法包括向哺乳动物施用有效量的以下物质之一：IGF-1; IGF-I的功能衍生物; IGF-II; IGF-II的功能衍生物; IGF-III; 或IGF-III的功能衍生物。
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8.发明授权Treating disorders by application of insulin-like growth factors and analogs 失效通过应用胰岛素样生长因子和类似物治疗疾病
公开(公告)号：US5652214A
公开(公告)日：1997-07-29
申请号：US958903
申请日：1992-10-07
申请人： Michael E. Lewis , James C. Kauer , Kevin R. Smith , Kathleen V. Callison , Frank Baldino , Nicola Neff , Mohamed Iqbal
发明人： Michael E. Lewis , James C. Kauer , Kevin R. Smith , Kathleen V. Callison , Frank Baldino , Nicola Neff , Mohamed Iqbal
摘要： A method of enhancing the survival of neuronal cells in a mammal, the cells being at risk of dying, the method including the step of administering to the mammal one of the following substances: IGF-I; a functional derivative of IGF-I; IGF-II; a functional derivative of IGF-II; IGF-III; or a functional derivative of IGF-III.
摘要翻译： 一种增强哺乳动物神经元细胞存活的方法，该细胞处于死亡的危险之中，该方法包括向哺乳动物施用以下物质之一：IGF-I; IGF-I的功能衍生物; IGF-II; IGF-II的功能衍生物; IGF-III; 或IGF-III的功能衍生物。
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9.发明授权Treating disorders by application of insulin-like growth factors and analogs 失效通过应用胰岛素样生长因子和类似物治疗疾病
公开(公告)号：US5703045A
公开(公告)日：1997-12-30
申请号：US462018
申请日：1995-06-05
申请人： Michael E. Lewis , James C. Kauer , Kevin R. Smith , Kathleen V. Callison , Frank Baldino , Nicola Neff , Mohamed Iqbal
发明人： Michael E. Lewis , James C. Kauer , Kevin R. Smith , Kathleen V. Callison , Frank Baldino , Nicola Neff , Mohamed Iqbal
IPC分类号： A61K38/27 , A61K38/00 , A61K38/30 , A61P25/00 , C07C7/06 , C07C7/08 , C07C7/10 , C07K14/65 , A61K37/24 , G07K7/10
摘要： A method of enhancing the survival of neuronal cells in a mammal, the cells being at risk of dying, the method comprising administering to the mammal an effective amount of at least one of the following substances: IGF-I; a functional derivative of IGF-I; IGF-II; a functional derivative of IGF-II; IGF-III; or a functional derivative of IGF-III.
摘要翻译： 一种增强哺乳动物神经元细胞存活的方法，该细胞处于死亡的危险之中，所述方法包括向哺乳动物施用有效量的至少一种下列物质：IGF-1; IGF-I的功能衍生物; IGF-II; IGF-II的功能衍生物; IGF-III; 或IGF-III的功能衍生物。
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10.发明授权Treating retinal neuronal disorders by the application of insulin-like growth factors and analogs 失效通过应用胰岛素样生长因子和类似物治疗视网膜神经元疾病公开(公告)号：US06310040B1
公开(公告)日：2001-10-30
申请号：US07963329
申请日：1992-10-15
IPC分类号： A61K3800
CPC分类号： A01N57/20 , A61K38/00 , C07F9/301 , C07F9/3813 , C07K14/65 , Y10S514/912 , Y10S530/839
摘要： Disclosed is a method for promoting retinal neuronal survival in a mammal, wherein the neuronal cells are at risk of dying. The method comprises administering to the mammal an effective dose of at least one of the following substances: IGF-I; a functional derivative of IGF-I; IGF-II; or a functional derivative of IGF-II.
摘要翻译： 公开了一种用于促进哺乳动物视网膜神经元存活的方法，其中神经细胞处于死亡的风险。 该方法包括向哺乳动物施用有效剂量的以下物质中的至少一种：IGF-1; IGF-I的功能衍生物; IGF-II; 或IGF-II的功能衍生物。
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