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公开(公告)号：US5756494A
公开(公告)日：1998-05-26
申请号：US456642
申请日：1995-06-02
申请人： Michael E. Lewis , James C. Kauer , Nicola Neff , Jill Roberts-Lewis , Chikara Murakata , Hiromitsu Saito , Yuzuru Matsuda , Marcie A. Glicksman , Fumihiko Kanai , Masami Kaneko
发明人： Michael E. Lewis , James C. Kauer , Nicola Neff , Jill Roberts-Lewis , Chikara Murakata , Hiromitsu Saito , Yuzuru Matsuda , Marcie A. Glicksman , Fumihiko Kanai , Masami Kaneko
IPC分类号： A61K31/40 , A61K31/407 , A61K31/41 , A61K31/415 , A61K31/44 , A61K31/505 , A61K31/5377 , A61K31/553 , A61K31/7056 , A61K38/22 , A61P9/00 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P31/18 , C07D487/14 , C07D498/22 , C07D519/00 , C07D498/12 , A61K31/55
CPC分类号： C07D487/14 , A61K31/407 , A61K31/5377 , A61K31/553 , A61K31/7056
摘要： The invention features novel derivatives of K-252a, as well as novel bis-N-substituted derivatives of staurosporine. The invention also features a method for treating diseased neuronal cells involving the administration of either the novel staurosporine derivatives or specified functional derivatives of K-252a.
摘要翻译： 本发明的特征在于K-252a的新衍生物以及星形孢菌素的新型双-N-取代衍生物。 本发明还涉及一种用于治疗患有神经元细胞的方法，涉及施用新型星形孢菌素衍生物或K-252a的特定功能衍生物。
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公开(公告)号：US5741808A
公开(公告)日：1998-04-21
申请号：US800383
申请日：1997-02-14
申请人： Michael E. Lewis , James C. Kauer , Nicola Neff , Jill Roberts-Lewis , Chikara Murakata , Hiromitsu Saito , Yuzuru Matsuda , Marcie A. Glicksman , Fumihiko Kanai , Masami Kaneko
发明人： Michael E. Lewis , James C. Kauer , Nicola Neff , Jill Roberts-Lewis , Chikara Murakata , Hiromitsu Saito , Yuzuru Matsuda , Marcie A. Glicksman , Fumihiko Kanai , Masami Kaneko
IPC分类号： A61K31/40 , A61K31/407 , A61K31/41 , A61K31/415 , A61K31/44 , A61K31/505 , A61K31/5377 , A61K31/553 , A61K31/7056 , A61K38/22 , A61P9/00 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P31/18 , C07D487/14 , C07D498/22 , C07D519/00 , A61K31/55
CPC分类号： C07D487/14 , A61K31/407 , A61K31/5377 , A61K31/553 , A61K31/7056
摘要： The invention features novel derivatives of K-252a, as well as novel bis-N-substituted derivatives of staurosporine. The invention also features a method for treating diseased neuronal cells involving the administration of either the novel staurosporine derivatives or specified functional derivatives of K-252a.
摘要翻译： 本发明的特征在于K-252a的新衍生物以及星形孢菌素的新型双-N-取代衍生物。 本发明还涉及一种用于治疗患有神经元细胞的方法，涉及施用新型星形孢菌素衍生物或K-252a的特定功能衍生物。
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公开(公告)号：US5621101A
公开(公告)日：1997-04-15
申请号：US486739
申请日：1995-06-07
申请人： Michael E. Lewis , James C. Kauer , Nicola Neff , Jill Roberts-Lewis , Chikara Murakata , Hiromitsu Saito , Yuzuru Matsuda , Marcie A. Glicksman , Fumihiko Kanai , Masami Kaneko
发明人： Michael E. Lewis , James C. Kauer , Nicola Neff , Jill Roberts-Lewis , Chikara Murakata , Hiromitsu Saito , Yuzuru Matsuda , Marcie A. Glicksman , Fumihiko Kanai , Masami Kaneko
IPC分类号： A61K31/407 , A61K31/5377 , A61K31/553 , A61K31/7056 , C07D487/14 , C07D498/22 , C07D519/00 , A61K31/55
CPC分类号： C07D487/14 , A61K31/407 , A61K31/5377 , A61K31/553 , A61K31/7056
摘要： The invention features novel derivatives of K-252a, as well as novel bis-N-substituted derivatives of staurosporine. The invention also features a method for treating diseased neuronal cells involving the administration of either the novel staurosporine derivatives or specified functional derivatives of K-252a.
摘要翻译： 本发明的特征在于K-252a的新衍生物以及星形孢菌素的新型双-N-取代衍生物。 本发明还涉及一种用于治疗患有神经元细胞的方法，涉及施用新型星形孢菌素衍生物或K-252a的特定功能衍生物。
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公开(公告)号：US5621100A
公开(公告)日：1997-04-15
申请号：US329540
申请日：1994-10-26
申请人： Michael E. Lewis , James C. Kauer , Nicola Neff , Jill Roberts-Lewis , Chikara Murakata , Hiromitsu Saito , Yuzuru Matsuda , Marcie A. Glicksman , Fumihiko Kanai , Masami Kaneko
发明人： Michael E. Lewis , James C. Kauer , Nicola Neff , Jill Roberts-Lewis , Chikara Murakata , Hiromitsu Saito , Yuzuru Matsuda , Marcie A. Glicksman , Fumihiko Kanai , Masami Kaneko
IPC分类号： A61K31/407 , A61K31/5377 , A61K31/553 , A61K31/7056 , C07D487/14 , C07D498/22 , C07D519/00 , A61K31/55
CPC分类号： C07D487/14 , A61K31/407 , A61K31/5377 , A61K31/553 , A61K31/7056
摘要： The invention features novel derivatives of K-252a, as well as novel bis-N-substituted derivatives of staurosporine. The invention also features a method for treating diseased neuronal cells involving the administration of either the novel staurosporine derivatives or specified functional derivatives of K-252a.
摘要翻译： 本发明的特征在于K-252a的新衍生物以及星形孢菌素的新型双-N-取代衍生物。 本发明还涉及一种用于治疗患有神经元细胞的方法，涉及施用新型星形孢菌素衍生物或K-252a的特定功能衍生物。
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5.发明授权
公开(公告)号：US5461146A
公开(公告)日：1995-10-24
申请号：US96561
申请日：1993-07-22
申请人： Michael E. Lewis , James C. Kauer , Nicola Neff , Jill Roberts-Lewis , Chikara Murakata , Hiromitsu Saito , Yuzuru Matsuda , Marcie A. Glicksman
发明人： Michael E. Lewis , James C. Kauer , Nicola Neff , Jill Roberts-Lewis , Chikara Murakata , Hiromitsu Saito , Yuzuru Matsuda , Marcie A. Glicksman
IPC分类号： A61K31/40 , A61K31/407 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/7056 , A61K38/22 , A61P9/10 , A61P21/04 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P31/18 , A61P43/00 , C07D487/14 , C07D498/22 , C07D519/00
CPC分类号： C07D487/14 , A61K31/407 , A61K31/5377 , A61K31/553 , A61K31/7056
摘要： The invention features novel derivatives of K-252a, as well as novel bis-N-substituted derivatives of staurosporine. Also, a method for treating diseased neuronal cells involving the administration of either the novel staurosporine derivatives or specified functional derivatives of K-252a.
摘要翻译： 本发明的特征在于K-252a的新衍生物以及星形孢菌素的新型双-N-取代衍生物。 另外，用于治疗患有神经元细胞的方法，涉及施用新型星形孢菌素衍生物或K-252a的特定功能衍生物。
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6.发明授权Treating disorders by application of insulin-like growth factors and analogs 失效通过应用胰岛素样生长因子和类似物治疗疾病
公开(公告)号：US5652214A
公开(公告)日：1997-07-29
申请号：US958903
申请日：1992-10-07
申请人： Michael E. Lewis , James C. Kauer , Kevin R. Smith , Kathleen V. Callison , Frank Baldino , Nicola Neff , Mohamed Iqbal
发明人： Michael E. Lewis , James C. Kauer , Kevin R. Smith , Kathleen V. Callison , Frank Baldino , Nicola Neff , Mohamed Iqbal
摘要： A method of enhancing the survival of neuronal cells in a mammal, the cells being at risk of dying, the method including the step of administering to the mammal one of the following substances: IGF-I; a functional derivative of IGF-I; IGF-II; a functional derivative of IGF-II; IGF-III; or a functional derivative of IGF-III.
摘要翻译： 一种增强哺乳动物神经元细胞存活的方法，该细胞处于死亡的危险之中，该方法包括向哺乳动物施用以下物质之一：IGF-I; IGF-I的功能衍生物; IGF-II; IGF-II的功能衍生物; IGF-III; 或IGF-III的功能衍生物。
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7.发明授权Treating disorders by application of insulin-like growth factors and analogs 失效通过应用胰岛素样生长因子和类似物治疗疾病
公开(公告)号：US5703045A
公开(公告)日：1997-12-30
申请号：US462018
申请日：1995-06-05
申请人： Michael E. Lewis , James C. Kauer , Kevin R. Smith , Kathleen V. Callison , Frank Baldino , Nicola Neff , Mohamed Iqbal
发明人： Michael E. Lewis , James C. Kauer , Kevin R. Smith , Kathleen V. Callison , Frank Baldino , Nicola Neff , Mohamed Iqbal
IPC分类号： A61K38/27 , A61K38/00 , A61K38/30 , A61P25/00 , C07C7/06 , C07C7/08 , C07C7/10 , C07K14/65 , A61K37/24 , G07K7/10
摘要： A method of enhancing the survival of neuronal cells in a mammal, the cells being at risk of dying, the method comprising administering to the mammal an effective amount of at least one of the following substances: IGF-I; a functional derivative of IGF-I; IGF-II; a functional derivative of IGF-II; IGF-III; or a functional derivative of IGF-III.
摘要翻译： 一种增强哺乳动物神经元细胞存活的方法，该细胞处于死亡的危险之中，所述方法包括向哺乳动物施用有效量的至少一种下列物质：IGF-1; IGF-I的功能衍生物; IGF-II; IGF-II的功能衍生物; IGF-III; 或IGF-III的功能衍生物。
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8.发明授权Treating disorders by application of insulin-like growth factors and analogs 失效通过应用胰岛素样生长因子和类似物治疗疾病
公开(公告)号：US5776897A
公开(公告)日：1998-07-07
申请号：US823245
申请日：1997-03-24
申请人： Michael E. Lewis , James C. Kauer , Kevin R. Smith , Kathleen V. Callison , Frank Baldino , Nicola Neff , Mohamed Iqbal
发明人： Michael E. Lewis , James C. Kauer , Kevin R. Smith , Kathleen V. Callison , Frank Baldino , Nicola Neff , Mohamed Iqbal
摘要： A method of enhancing the survival of neuronal cells in a mammal, the cells being at risk of dying, the method comprising administering to the mammal an effective amount of one of the following substances: IGF-I; a functional derivative of IGF-I; IGF-II; a functional derivative of IGF-II; IGF-III; or a functional derivative of IGF-III.
摘要翻译： 一种增强哺乳动物神经元细胞存活的方法，所述细胞处于死亡的危险之中，该方法包括向哺乳动物施用有效量的以下物质之一：IGF-1; IGF-I的功能衍生物; IGF-II; IGF-II的功能衍生物; IGF-III; 或IGF-III的功能衍生物。
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公开(公告)号：US5093317A
公开(公告)日：1992-03-03
申请号：US361595
申请日：1989-06-05
IPC分类号： A61K38/27 , A61K38/00 , A61K38/22 , A61K38/30 , A61P25/00 , A61P25/28 , C07K1/113 , C07K14/65
CPC分类号： C07K14/65 , A61K38/30 , C07K1/113 , Y10S514/885 , Y10S514/903
摘要： Method of enhancing the survival of neuronal cells, more preferably non-mitotic neuronal cells and/or cholinergic cells in a mammal, which cells are at risk of dying, which method includes administering to the mammal an effective amount of a functional derivative of Insulin-like Growth Factor I or Insulin-like Growth Factor II.
摘要翻译： 提高哺乳动物中神经元细胞，更优选非有丝分裂神经元细胞和/或胆碱能细胞的存活的方法，该细胞处于死亡的危险中，该方法包括向哺乳动物施用有效量的胰岛素 - 如生长因子I或胰岛素样生长因子II。
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公开(公告)号：US06693076B1
公开(公告)日：2004-02-17
申请号：US09318001
申请日：1999-05-25
IPC分类号： A61K3830
摘要： A method of enhancing the survival of neuronal cells in a mammal, the cells being at risk of dying, the method comprising administering to the mammal an effective amount of one of the following substances: IGF-I; a functional derivative of IGF-I; IGF-II; a functional derivative of IGF-II; IGF-III; or a functional derivative of IGF-III.
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