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公开(公告)号：US08423116B2
公开(公告)日：2013-04-16
申请号：US10593318
申请日：2005-03-16
IPC分类号： A61B5/05
CPC分类号： A61B5/1455 , A61B5/14546 , A61B5/14553 , A61B5/7475 , A61B8/06 , A61B8/0808 , A61B8/0816 , A61B8/4227 , A61B8/4494 , A61B2562/0233 , A61B2562/043 , G01S15/8968
摘要： A measurement system and method are presented for use for non-invasive measurements in a human body. Acoustic radiation is applied to a certain illuminated region in the body, with at least two different conditions of the applied radiation achievable by varying at least one characteristic of the acoustic radiation. Light scattered from the body part is detected, and measured data indicative of detected photons tagged and untagged by the acoustic radiation is generated. The measured data is analyzed to extract therefrom a data portion corresponding to the tagged photons and being therefore associated with a light response of said certain region, thereby enabling determination of tissue properties of said certain region based on a relation between the measured data portions corresponding to the at least two different operating conditions.
摘要翻译： 提出了一种用于人体无创测量的测量系统和方法。 声辐射被施加到身体中的某个照明区域，通过改变声辐射的至少一个特征可以实现所施加辐射的至少两个不同条件。 检测到从身体部分散射的光，并且产生指示被声辐射标记和未标记的检测到的光子的测量数据。 分析测量数据以从其中提取对应于标记的光子的数据部分，并且因此与所述特定区域的光响应相关联，从而可以基于对应于所述特定区域的测量数据部分之间的关系来确定所述特定区域的组织属性 至少两个不同的操作条件。
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公开(公告)号：US20080312533A1
公开(公告)日：2008-12-18
申请号：US10593318
申请日：2005-03-16
CPC分类号： A61B5/1455 , A61B5/14546 , A61B5/14553 , A61B5/7475 , A61B8/06 , A61B8/0808 , A61B8/0816 , A61B8/4227 , A61B8/4494 , A61B2562/0233 , A61B2562/043 , G01S15/8968
摘要： A measurement system and method are presented for use for non-invasive measurements in a human body. Acoustic radiation is applied to a certain illuminated region in the body, with at least two different conditions of the applied radiation achievable by varying at least one characteristic of the acoustic radiation. Light scattered from the body part is detected, and measured data indicative of detected photons tagged and untagged by the acoustic radiation is generated. The measured data is analyzed to extract therefrom a data portion corresponding to the tagged photons and being therefore associated with a light response of said certain region, thereby enabling determination of tissue properties of said certain region based on a relation between the measured data portions corresponding to the at least two different operating conditions.
摘要翻译： 提出了一种用于人体无创测量的测量系统和方法。 声辐射被施加到身体中的某个照明区域，通过改变声辐射的至少一个特征可以实现所施加辐射的至少两个不同条件。 检测到从身体部分散射的光，并且产生指示被声辐射标记和未标记的检测到的光子的测量数据。 分析测量数据以从其中提取对应于标记的光子的数据部分，并且因此与所述特定区域的光响应相关联，从而可以基于对应于所述特定区域的测量数据部分之间的关系来确定所述特定区域的组织属性 至少两个不同的操作条件。
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公开(公告)号：US07515948B1
公开(公告)日：2009-04-07
申请号：US10938880
申请日：2004-09-13
IPC分类号： A61B5/1455
CPC分类号： A61B5/14542 , A61B5/0095 , A61B5/02411 , A61B5/1464 , A61B5/7264 , A61B7/00
摘要： A method and apparatus are presented for non-invasively monitoring at least one characteristic of a region of interest in a body. The body is illuminated by pulsed light to induce a photoacoustic effect. Acoustic radiation is detected, and measured data indicative thereof is generated. The photoacoustic effect is controlled by carrying out at least one of the following: providing the pulsed light of at least two different wavelength, analyzing the measured data to determine time variations of at least one predetermined parameter of a time dependent acoustic signal for each of wavelength, and determining oxygen saturation level in the region of interest; and operating a plurality of acoustic elements configured for detection of the acoustic radiation, to thereby define a focal volume for acoustic radiation detection to match dimensions of the region of interest.
摘要翻译： 提出了用于非侵入性地监测身体中的感兴趣区域的至少一个特征的方法和装置。 身体被脉冲光照射以引起光声效应。 检测声辐射，产生表示其的测量数据。 通过执行以下至少一个来控制光声效应：提供至少两个不同波长的脉冲光，分析测量数据以确定每个波长的时间依赖声学信号的至少一个预定参数的时间变化 并确定感兴趣区域中的氧饱和度水平; 以及操作配置用于检测声辐射的多个声学元件，从而限定用于声辐射检测的焦点体积，以匹配感兴趣区域的尺寸。
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4.发明授权Method and apparatus for noninvasively monitoring parameters of a region of interest in a human body 有权用于非侵入性地监测人体感兴趣区域的参数的方法和装置公开(公告)号：US08126524B2
公开(公告)日：2012-02-28
申请号：US10545798
申请日：2004-09-12
IPC分类号： A61B5/1455 , A61B6/00
CPC分类号： A61B5/1464 , A61B5/0097 , A61B5/02411 , A61B5/08 , A61B5/14542 , A61B5/7264 , A61B2562/0233 , A61B2562/043 , G01S15/8968
摘要： A method and system for noninvasive monitoring of at least one parameter of a region of interest in a human body. The system comprises a measurement unit and a control unit. The measurement unit comprises an optical unit having an illumination assembly (101A) and a light detection assembly (101B) to generate measured data indicative of collected light; and an acoustic unit (110) configured to generate acoustic waves of a predetermined ultrasound frequency range. The measurement unit provides an operating condition such that the acoustic waves overlap with an illuminating region within the region of interest and substantially do not overlap outside the region of interest. The measured data is indicative of scattered light having both ultrasound tagged and untagged light portions, enabling to distinguish between light responses of the region of interest and the region outside the region of interest.
摘要翻译： 一种用于对人体内感兴趣区域的至少一个参数进行无创监测的方法和系统。 该系统包括测量单元和控制单元。 测量单元包括具有照明组件（101A）和光检测组件（101B）的光学单元，用于产生指示所收集的光的测量数据; 以及被配置为产生预定的超声频率范围的声波的声学单元（110）。 测量单元提供操作条件，使得声波与感兴趣区域内的照明区域重叠，并且基本上不在感兴趣区域外部重叠。 测量数据表示具有超声标记和未标记的光部分的散射光，能够区分感兴趣区域的光响应和感兴趣区域之外的区域。
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5.发明申请METHOD AND APPARATUS FOR NONINVASIVELY MONITORING PARAMETERS OF A REGION OF INTEREST IN A HUMAN BODY 有权一个人体感兴趣区域的非易失性监测参数的方法和装置公开(公告)号：US20120184830A1
公开(公告)日：2012-07-19
申请号：US13356053
申请日：2012-01-23
IPC分类号： A61B5/1455 , A61B6/00
CPC分类号： A61B5/1464 , A61B5/0097 , A61B5/02411 , A61B5/08 , A61B5/14542 , A61B5/7264 , A61B2562/0233 , A61B2562/043 , G01S15/8968
摘要： Apparatus and methods are provided for monitoring a parameter of a region of interest (ROI) within a first tissue type within a body. A control unit drives a measurement unit to provide an operating condition such that acoustic waves overlap with a region within the ROI that is illuminated by illuminating light such as to generate a first set of tagged photons, and such that the acoustic waves overlap with a region of tissue within a second tissue type that is illuminated by illuminating light such as to generate a second set of tagged photons, the first and second sets of tagged photons being distinguishable from one another. The control unit determines the parameter of the ROI by extracting data portions associated with, respectively, the light response of the ROI and the light response of the second tissue type, by distinguishing between the sets of tagged photons.
摘要翻译： 提供了用于监测身体内的第一组织类型内的感兴趣区域（ROI）的参数的装置和方法。 控制单元驱动测量单元以提供操作条件，使得声波与由照明光照射的ROI内的区域重叠，以产生第一组标记光子，并且使得声波与区域重叠 在通过照明光照射的第二组织类型中的组织，以产生第二组标记的光子，所述第一组和第二组标记的光子彼此可区分。 控制单元通过区分两组标记的光子来分别提取与ROI的光响应和第二组织类型的光响应相关联的数据部分来确定ROI的参数。
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6.发明申请Method and apparatus for noninvasively monitoring parameters of a region of interest in a human body 有权用于非侵入性地监测人体感兴趣区域的参数的方法和装置公开(公告)号：US20060247506A1
公开(公告)日：2006-11-02
申请号：US10545798
申请日：2004-09-12
IPC分类号： A61B5/00
CPC分类号： A61B5/1464 , A61B5/0097 , A61B5/02411 , A61B5/08 , A61B5/14542 , A61B5/7264 , A61B2562/0233 , A61B2562/043 , G01S15/8968
摘要： A method and system for noninvasive monitoring of at least one parameter of a region of interest in a human body. The system comprises a measurement unit and a control unit. The measurement unit comprises an optical unit having an illumination assembly (101A) and a light detection assembly (101B) to generate measured data indicative of collected light; and an acoustic unit (110) configured to generate acoustic waves of a predetermined ultrasound frequency range. The measurement unit provides an operating condition such that the acoustic waves overlap with an illuminating region within the region of interest and substantially do not overlap outside the region of interest. The measured data is indicative of scattered light having both ultrasound tagged and untagged light portions, enabling to distinguish between light responses of the region of interest and the region outside the region of interest.
摘要翻译： 一种用于对人体内感兴趣区域的至少一个参数进行无创监测的方法和系统。 该系统包括测量单元和控制单元。 测量单元包括具有照明组件（101A）和光检测组件（101B）的光学单元，以产生指示所收集的光的测量数据; 以及被配置为产生预定的超声频率范围的声波的声学单元（110）。 测量单元提供操作条件，使得声波与感兴趣区域内的照明区域重叠，并且基本上不在感兴趣区域外部重叠。 测量数据表示具有超声标记和未标记的光部分的散射光，能够区分感兴趣区域的光响应和感兴趣区域之外的区域。
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7.发明申请Method and apparatus for noninvasively monitoring parameters of a region of interest in a human body 有权用于非侵入性地监测人体感兴趣区域的参数的方法和装置公开(公告)号：US20060122475A1
公开(公告)日：2006-06-08
申请号：US11327381
申请日：2006-01-09
IPC分类号： A61B5/00
CPC分类号： A61B5/1464 , A61B5/0097 , A61B5/02411 , A61B5/08 , A61B5/14542 , A61B5/7264 , A61B2562/0233 , A61B2562/043 , G01S15/8968
摘要： A method and system are presented for use in noninvasive monitoring at least one parameter of a region of interest in a human body. The system comprises a measurement unit and a control unit. The measurement unit comprises an optical unit having an illumination assembly configured to define at least one output port for illuminating light, and a light detection assembly configured to define at least one light input port for collecting light and to generate measured data indicative of the collected light; and an acoustic unit configured to generate acoustic waves of a predetermined ultrasound frequency range. The measurement unit is configured and operable to provide an operating condition such that the acoustic waves of the predetermined frequency range overlap with an illuminating region within the region of interest and substantially do not overlap with a region outside the region of interest, and that the detection assembly collects light scattered from the region of interest and light scattered from the region outside the region of interest. The measured data is thus indicative of scattered light having both ultrasound tagged and untagged light portions, thereby enabling to distinguish between light responses of the region of interest and the region outside the region of interest. The control unit is connectable to the optical unit and to the acoustic unit to operate these units, and is responsive to the measured data and preprogrammed to process and analyze the measured data to extract therefrom data indicative of a light response of the region of interest and determine the at least one desired parameter.
摘要翻译： 提出了一种方法和系统，用于非侵入性监测人体感兴趣区域的至少一个参数。 该系统包括测量单元和控制单元。 测量单元包括光学单元，其具有被配置为限定用于照明光的至少一个输出端口的照明组件;以及光检测组件，其被配置为限定用于收集光的至少一个光输入端口并且产生指示所收集的光的测量数据 ; 以及声学单元，被配置为产生预定的超声频率范围的声波。 测量单元被配置和操作以提供操作条件，使得预定频率范围的声波与感兴趣区域内的照明区域重叠，并且基本上不与感兴趣区域外的区域重叠，并且检测 装配收集从感兴趣区域以外的区域分散的光和从感兴趣区域以外的区域分散的光。 因此，所测量的数据表示具有超声标记和未标记的光部分的散射光，从而能够区分感兴趣区域的光响应和感兴趣区域之外的区域。 控制单元可连接到光学单元和声学单元以操作这些单元，并且响应于测量数据并被预编程以处理和分析测量数据以从其中提取指示感兴趣区域的光响应的数据，以及 确定至少一个期望的参数。
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8.发明授权Method and apparatus for noninvasively monitoring parameters of a region of interest in a human body 有权用于非侵入性地监测人体感兴趣区域的参数的方法和装置公开(公告)号：US08108022B2
公开(公告)日：2012-01-31
申请号：US11327381
申请日：2006-01-09
IPC分类号： A61B5/1455 , A61B6/00
CPC分类号： A61B5/1464 , A61B5/0097 , A61B5/02411 , A61B5/08 , A61B5/14542 , A61B5/7264 , A61B2562/0233 , A61B2562/043 , G01S15/8968
摘要： Apparatus and methods including a probe device for monitoring a parameter of a region of interest in a human body. A support structure of the device carries an arrangement of light output ports of a light source assembly, light input ports of a light detection assembly, and an acoustic output port of an acoustic unit. The arrangement is such as to enable selection of a light output port, a light input port, and an acoustic output port for an operating condition at which, acoustic waves from the acoustic output port and illuminating light from the light output port overlap in a region within the region of interest in the body thereby inducing tagging of light by the acoustic waves, and the light input port collects light scattered from the overlapping region and light scattered from outside the region of interest. Other embodiments are also described.
摘要翻译： 包括用于监测人体感兴趣区域的参数的探针装置的装置和方法。 该装置的支撑结构携带光源组件的光输出端口，光检测组件的光输入端口和声学单元的声输出端口的布置。 该布置使得能够选择光输出端口，光输入端口和声输出端口，用于来自声输出端口的声波和来自光输出端口的照明光在区域中重叠的操作条件 在体内感兴趣的区域内，由于声波引起光的标记，光输入端口收集从重叠区域散射的光和从感兴趣区域外部散射的光。 还描述了其它实施例。
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9.发明授权Method and apparatus for noninvasively monitoring parameters of a region of interest in a human body 有权用于非侵入性地监测人体感兴趣区域的参数的方法和装置公开(公告)号：US08644900B2
公开(公告)日：2014-02-04
申请号：US13356053
申请日：2012-01-23
IPC分类号： A61B5/1455
CPC分类号： A61B5/1464 , A61B5/0097 , A61B5/02411 , A61B5/08 , A61B5/14542 , A61B5/7264 , A61B2562/0233 , A61B2562/043 , G01S15/8968
摘要： Apparatus and methods are provided for monitoring a parameter of a region of interest (ROI) within a first tissue type within a body. A control unit drives a measurement unit to provide an operating condition such that acoustic waves overlap with a region within the ROI that is illuminated by illuminating light such as to generate a first set of tagged photons, and such that the acoustic waves overlap with a region of tissue within a second tissue type that is illuminated by illuminating light such as to generate a second set of tagged photons, the first and second sets of tagged photons being distinguishable from one another. The control unit determines the parameter of the ROI by extracting data portions associated with, respectively, the light response of the ROI and the light response of the second tissue type, by distinguishing between the sets of tagged photons.
摘要翻译： 提供了用于监测身体内的第一组织类型内的感兴趣区域（ROI）的参数的装置和方法。 控制单元驱动测量单元以提供操作条件，使得声波与由照明光照射的ROI内的区域重叠，以产生第一组标记光子，并且使得声波与区域重叠 在通过照明光照射的第二组织类型中的组织，以产生第二组标记的光子，所述第一组和第二组标记的光子彼此可区分。 控制单元通过区分两组标记的光子来分别提取与ROI的光响应和第二组织类型的光响应相关联的数据部分来确定ROI的参数。
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