公开(公告)号：US4462689A

公开(公告)日：1984-07-31

申请号：US398090

申请日：1982-07-09

申请人： Milton N. Kabler ,  Richard T. Williams ,  Jack C. Rife ,  William R. Hunter ,  Johnny P. Kirkland ,  Neil C. Lien

发明人： Milton N. Kabler ,  Richard T. Williams ,  Jack C. Rife ,  William R. Hunter ,  Johnny P. Kirkland ,  Neil C. Lien

IPC分类号： G01J3/18 ,  G21K1/06

CPC分类号： G21K1/06 ,  G01J3/18

摘要： A scanning monochromator is disclosed which is capable of operation over a wide bandwidth in an ultra-high vacuum. The monochromator includes a pair of carousel assemblies carrying the optical elements which may be independently positioned translationally along the optical axis of the instrument and also rotationally, which each positioning control operable from outside of the instrument. A carousel on each of the carousel assemblies carries several optical elements and is rotatable to change which optical element is used, also from outside of the instrument.

摘要翻译： 公开了能够在超高真空下在宽带宽下工作的扫描单色仪。 单色仪包括一对传送带组件，其携带光学元件，其可以沿着仪器的光轴平行地单独定位，并且还可旋转地，每个定位控制器可从仪器的外部操作。 每个转盘组件上的转盘带有几个光学元件，并且也可以从仪器的外部旋转以改变使用哪个光学元件。

公开(公告)号：US07103949B2

公开(公告)日：2006-09-12

申请号：US10339257

申请日：2003-01-06

申请人： Jack C. Rife ,  Michael I. Bell ,  James Horwitz ,  Milton N. Kabler

发明人： Jack C. Rife ,  Michael I. Bell ,  James Horwitz ,  Milton N. Kabler

IPC分类号： H04R17/00 ,  F04B17/00

CPC分类号： F04F7/00 ,  B01F11/025 ,  F04B17/00 ,  F04B17/003 ,  F04D33/00 ,  Y10T29/42 ,  Y10T29/49005 ,  Y10T29/49117 ,  Y10T137/2196

摘要： A method for fabricating a transducer suitable for a fluidic drive for a miniature acoustic-fluidic pump or mixer that includes an acoustic transducer attached to an exterior or interior of a fluidic circuit or reservoir. The transducer converts radio frequency electrical energy into an ultrasonic acoustic wave in a fluid that in turn generates directed fluid motion through the effect of acoustic streaming. The method includes depositing a piezo-electric thin-film onto a platinum coated silicon wafer or substrate with capping electrodes, defining each separate transducer; and dicing said piezoelectric tin-film to provide individual transducers.

摘要翻译： 一种用于制造适用于微型声流泵或混合器的流体驱动器的换能器的方法，其包括附接到流体回路或储存器的外部或内部的声学换能器。 换能器将射频电能转换成流体中的超声波声音，其又通过声流的效果产生指向的流体运动。 该方法包括将压电薄膜沉积到具有封盖电极的镀铂硅晶片或衬底上，限定每个单独的换能器; 并切割所述压电薄膜以提供单独的换能器。

公开(公告)号：US06568052B1

公开(公告)日：2003-05-27

申请号：US09599865

申请日：2000-06-23

申请人： Jack C. Rife ,  Michael I. Bell ,  James Horwitz ,  Milton N. Kabler

发明人： Jack C. Rife ,  Michael I. Bell ,  James Horwitz ,  Milton N. Kabler

IPC分类号： H04R1700

CPC分类号： F04F7/00 ,  B01F11/025 ,  F04B17/00 ,  F04B17/003 ,  F04D33/00 ,  Y10T29/42 ,  Y10T29/49005 ,  Y10T29/49117 ,  Y10T137/2196

摘要： The fluidic drive for miniature acoustic-fluidic pump and mixer is comprised of an acoustic transducer attached to an exterior or interior of a fluidic circuit or reservoir. The transducer converts radio frequency electrical energy into an ultrasonic acoustic wave in a fluid that in turn generates directed fluid motion through the effect of acoustic streaming. Acoustic streaming results due to the absorption of the acoustic energy in the fluid itself. This absorption results in a radiation pressure and acoustic streaming in the direction of propagation of the acoustic propagation or what is termed “quartz wind”.

摘要翻译： 用于微型声流泵和混合器的流体驱动器包括附接到流体回路或储存器的外部或内部的声学换能器。 换能器将射频电能转换成流体中的超声波声音，其又通过声流的效果产生指向的流体运动。 由于流体本身中的声能的吸收，声流结果。 这种吸收导致在声传播传播方向上的辐射压力和声流，或称为“石英风”。

公开(公告)号：US06210128B1

公开(公告)日：2001-04-03

申请号：US09293153

申请日：1999-04-16

申请人： Jack C. Rife ,  Michael I. Bell ,  James Horwitz ,  Milton N. Kabler

发明人： Jack C. Rife ,  Michael I. Bell ,  James Horwitz ,  Milton N. Kabler

IPC分类号： F04B1700

CPC分类号： F04F7/00 ,  B01F11/025 ,  F04B17/00 ,  F04B17/003 ,  F04D33/00 ,  Y10T29/42 ,  Y10T29/49005 ,  Y10T29/49117 ,  Y10T137/2196

摘要： The fluidic drive for miniature acoustic-fluidic pump and mixer is comprised of an acoustic transducer attached to an exterior or interior of a fluidic circuit or reservoir. The transducer converts radio frequency electrical energy into an ultrasonic acoustic wave in a fluid that in turn generates directed fluid motion through the effect of acoustic streaming. Acoustic streaming results due to the absorption of the acoustic energy in the fluid itself. This absorption results in a radiation pressure and acoustic streaming in the direction of propagation of the acoustic propagation or what is termed “quartz wind”.

摘要翻译： 用于微型声流泵和混合器的流体驱动器包括附接到流体回路或储存器的外部或内部的声学换能器。 换能器将射频电能转换成流体中的超声波声音，其又通过声流的效果产生指向的流体运动。 由于流体本身中的声能的吸收，声流结果。 这种吸收导致在声传播传播方向上的辐射压力和声流，或称为“石英风”。

公开(公告)号：US4574198A

公开(公告)日：1986-03-04

申请号：US576386

申请日：1984-01-09

申请人： Amand A. Lucas ,  Jack C. Rife ,  Stephen E. Donnelly

发明人： Amand A. Lucas ,  Jack C. Rife ,  Stephen E. Donnelly

IPC分类号： G01N23/22 ,  H01J63/00 ,  H01J65/04 ,  G21G4/00

CPC分类号： H01J63/00

摘要： Method and device for producing photons (7), in the UV-wavelength range, comprising planting in a solid matrix, ions from a gas which is inert or insoluble relative to the matrix, excitating the captive gas (2) in the solid matrix, and emitting of said photons (7) by the excitated gas, as well as notably the ionic bombardment of one surface from the solid matrix with low-energy ions from at least one gas as stated above, and the electronic bombardment (4) with low energy of the solid matrix, with emission of the photons (7).

摘要翻译： PCT No.PCT / BE83 / 00010 Sec。 371日期1984年1月9日第 102（e）日期1984年1月9日PCT提交1983年5月5日PCT公布。 出版物WO83 / 04099 日期：1983年11月24日。用于生产光子（7）的方法和装置，在UV波长范围内，包括以固体基质种植，来自相对于基质惰性或不溶性的气体的离子，激发捕获气体 2）在固体基质中，并且通过激发气体发射所述​​光子（7），特别是如上所述从至少一种气体的低能量离子从固体基质离子轰击一个表面，并且 电子轰击（4）具有低能量的固体基质，发射光子（7）。

公开(公告)号：US07736889B2

公开(公告)日：2010-06-15

申请号：US10457705

申请日：2003-06-10

申请人： Jack C. Rife ,  Lloyd J. Whitman

发明人： Jack C. Rife ,  Lloyd J. Whitman

IPC分类号： C12M1/36 ,  C12M1/38 ,  C12M3/00

CPC分类号： G01N33/587 ,  G01N33/54306 ,  Y10S435/962

摘要： This invention describes a method of using controlled fluidic forces to improve the performance of a biochemical binding assay where a target molecule is captured by specific molecular recognition onto a substrate surface with an affinity coating, and then labeled with a detectable micrometer-scale particle using a second specific molecular recognition reaction with the target. By using specific ranges of label sizes and laminar flow conditions, controlled fluidic forces can be applied to the label particles in order to selectively remove molecules bound to a surface according to their binding strength, and thereby increase the ratio of specifically bound labels to more weakly attached non-specifically bound labels. This method can be used with a wide variety of label types and associated detection methods, improving the sensitivity and selectivity of a broad range of binding assays.

摘要翻译： 本发明描述了使用受控流体力来提高生物化学结合测定的性能的方法，其中靶分子通过特异性分子识别被捕获到具有亲和涂层的基底表面上，然后用可检测的微米级粒子标记，使用 第二个具体的分子识别反应与目标。 通过使用特定范围的标签尺寸和层流条件，可以将受控的流体力施加到标签颗粒上，以根据其结合强度有选择地去除与表面结合的分子，从而增加特异性结合的标签与更弱的比例 附加非特异性结合标签。 该方法可用于多种标记类型和相关检测方法，从而提高广泛结合测定的灵敏度和选择性。

公开(公告)号：US20100144057A1

公开(公告)日：2010-06-10

申请号：US12564679

申请日：2009-09-22

申请人： Jack C. Rife ,  Lloyd J. Whitman

发明人： Jack C. Rife ,  Lloyd J. Whitman

IPC分类号： G01N33/566

CPC分类号： G01N33/587 ,  G01N33/54306 ,  Y10S435/962

摘要： This invention describes a method of using controlled fluidic forces to improve the performance of a biochemical binding assay where a target molecule is captured by specific molecular recognition onto a substrate surface with an affinity coating, and then labeled with a detectable micrometer-scale particle using a second specific molecular recognition reaction with the target. By using specific ranges of label sizes and laminar flow conditions, controlled fluidic forces can be applied to the label particles in order to selectively remove molecules bound to a surface according to their binding strength, and thereby increase the ratio of specifically bound labels to more weakly attached non-specifically bound labels. This method can be used with a wide variety of label types and associated detection methods, improving the sensitivity and selectivity of a broad range of binding assays.

摘要翻译： 本发明描述了使用受控流体力来提高生物化学结合测定的性能的方法，其中靶分子通过特异性分子识别被捕获到具有亲和涂层的基底表面上，然后用可检测的微米级粒子标记，使用 第二个具体的分子识别反应与目标。 通过使用特定范围的标签尺寸和层流条件，可以将受控的流体力施加到标签颗粒上，以根据其结合强度有选择地去除与表面结合的分子，从而增加特异性结合的标签与更弱的比例 附加非特异性结合标签。 该方法可用于多种标记类型和相关检测方法，从而提高广泛结合测定的灵敏度和选择性。