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Patent Agency Ranking
公开(公告)号：US20220001379A1
公开(公告)日：2022-01-06
申请号：US17290568
申请日：2019-11-11
Inventor： Katsuo MOGI , Shungo ADACHI , Tomoya INOUE , Tohru NATSUME
Abstract: A liquid manipulation device has an enhanced ability to control liquid, in particular, a droplet, and offers improved fabrication efficiency. The liquid manipulation device according to the present invention includes: a substrate 1, 11 including a sheet shape or a film shape to have flexibility; a plurality of electrodes 2 located on a front surface 1b, 11b of the substrate 1, 11; and an insulating layer located over the front surface 1b, 11b of the substrate 1, 11 to cover the electrodes 2. The liquid manipulation device is configured to move liquid L on a front surface 3b of the insulating layer 3 by using an electrostatic force that is generated when voltage is applied to at least one of the electrodes 2. In the liquid manipulation device, the insulating layer 3 includes dimples 4 that are located in correspondence with the electrodes 2 and are curved concave in a concave direction directed from the front surface 3b of the insulating layer 3 toward the back surface 3a of the insulating layer 3. Each of the electrodes 2 includes a dimple-corresponding portion 5 being curved concave in the concave direction together with one of the dimples 4 that is located in correspondence with the corresponding electrode 2.
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公开(公告)号：US20220126256A1
公开(公告)日：2022-04-28
申请号：US17430677
申请日：2020-02-07
Inventor： Katsuo MOGI , Shungo ADACHI , Tomoya INOUE , Tohru NATSUME
IPC: B01J19/08
Abstract: An open-type liquid manipulation device can divide liquid, in particular, a droplet efficiently. The open-type liquid manipulation device according to the present invention includes: a substrate 1, 11, 21; at least three electrodes 2, 12, 13, 22, 23 located on a front surface 1b, 11b, 21b of the substrate 1, 11, 21; and an insulating layer 3, 14, 24 located over the front surface 1b, 11b, 21b of the substrate 1, 11, 21 to cover the at least three electrodes 2, 12, 13, 22, 23. The device includes a groove 4, 15, 25 that is concave in a direction from a front surface 3b, 14b, 24b of the insulating layer 3, 14, 24 toward a back surface 3a, 14a, 24a of the insulating layer 3, 14, 24. The groove 4, 15, 25 extends straddling the at least three electrodes. Liquid L is controlled on the front surface 3b, 14b, 24b of the insulating layer 3, 14, 24 by using a change in electrostatic force generated by changing voltage applied to the electrodes 2, 12, 13, 22, 23.
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公开(公告)号：US20170108521A1
公开(公告)日：2017-04-20
申请号：US15126831
申请日：2015-03-19
Applicant: National Institute of Advanced Industrial Science and Technology , Robotic Biology Institute Inc.
Inventor： Naoyuki SASAKI , Tohru NATSUME
CPC classification number: G01N35/0099 , B01L3/0213 , B01L3/0237 , B01L2200/082 , B01L2200/146 , B25J11/00 , G01N35/10
Abstract: Provided is a pipette device that can discharge or withdraw a liquid easily by liquid processing operation by a robot device. Provided is a pipette device held by a robot device, comprising a driving part for withdrawing and/or discharging a liquid, a signal receiving part for receiving a signal from the robot device and a control part for controlling the driving part according to the signal.
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公开(公告)号：US20210387197A1
公开(公告)日：2021-12-16
申请号：US17317273
申请日：2021-05-11
Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY , KYOTO PHARMACEUTICAL UNIVERSITY
Inventor： Katsuo MOGI , Tohru NATSUME , Shungo ADACHI , Tomoya INOUE , Hiroyuki KIMURA
IPC: B01L3/00
Abstract: A method for producing a liquid reaction mixture containing a radioisotope, in particular, a radioactive composition, minimizes device contamination with radioactive substances and increase speed and accuracy with which droplets are mixed. The method for producing a radioactive composition includes placing at least one first droplet L1 containing a radionuclide and at least one second droplet L2 containing a labeling substance on at least two respective dimples 5 among dimples 5 on a front surface 4b of an insulating layer 4 of a liquid manipulation device 1, and obtaining a liquid mixture M by using a change in electrostatic force caused by changing voltage applied to the electrodes 3 to thereby cause a relative movement between the at least one first droplet L1 and the at least one second droplet L2 so that the at least one first droplet L1 and the at least one second droplet L2 are mixed together at any one dimple among the dimples 5.
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公开(公告)号：US20190314360A1
公开(公告)日：2019-10-17
申请号：US16453393
申请日：2019-06-26
Applicant: FUJIFILM Corporation , FUJIFILM Toyama Chemical Co., Ltd. , NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
Inventor： Keiko MAKITA , Kazunori SAEKI , Tadashi TANAKA , Masataka FUJINO , Tohru NATSUME , Kentaro FURUYA
IPC: A61K31/4704 , A61K31/5377 , A61K31/4709 , A61K31/4725 , A61K31/498 , A61K31/497 , A61P35/02 , A61P35/00
Abstract: It is an object of the present invention to provide an antitumor agent, which is further excellent as a treatment agent used in the prevention and/or therapy of tumor associated with a bromodomain, and also to provide a bromodomain inhibitor, which is useful as a treatment agent for diseases or states associated with a bromodomain.An antitumor agent and a bromodomain inhibitor, comprising a compound represented by the following formula, have an excellent bromodomain inhibitory activity and are useful as treatment agents in the prevention and/or therapy of tumor associated with a bromodomain, and the like: wherein R1 represents a C1-6 alkyl group, etc.; R2 represents a hydrogen atom, etc.; R3 represents a halogen atom, etc.; Z1, Z2 and Z3 each represent CH, etc.; X1 represents CONH, etc.; Ring A represents a phenyl group, etc.; R4 represents a halogen atom, etc.; and m represents an integer from 0 to 5.
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