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    KIDNEY-TARGETING DRUG DELIVERY CARRIER
    3.
    发明申请
    KIDNEY-TARGETING DRUG DELIVERY CARRIER 审中-公开

    公开(公告)号：US20200237669A1

    公开(公告)日：2020-07-30

    申请号：US16628530

    申请日：2018-07-06

    Applicant: KYOTO PHARMACEUTICAL UNIVERSITY

    Inventor： Hidemasa Katsumi ,  Akira Yamamoto

    IPC: A61K9/14 ,  A61K31/401 ,  A61K47/60 ,  A61P13/12

    Abstract: The present invention relates to a compound having a macromolecular carrier having a plurality of terminal groups, wherein the carbonyl group of serine is linked by a peptide bond or an ester bond directly or via a linker to the terminal groups, a carrier for drug delivery composed of the compound, and a medicament for preventing or treating renal diseases, containing the carrier for drug delivery and a drug bonded to the carrier directly or via a linker or encapsulated therein. According to the present invention, a carrier for drug delivery that is selectively accumulated in kidney in vivo can be provided.

    METHOD FOR PRODUCING RADIOACTIVE COMPOSITION
    4.
    发明申请
    METHOD FOR PRODUCING RADIOACTIVE COMPOSITION 有权

    公开(公告)号：US20210387197A1

    公开(公告)日：2021-12-16

    申请号：US17317273

    申请日：2021-05-11

    Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY ,  KYOTO PHARMACEUTICAL UNIVERSITY

    Inventor： Katsuo MOGI ,  Tohru NATSUME ,  Shungo ADACHI ,  Tomoya INOUE ,  Hiroyuki KIMURA

    IPC: B01L3/00

    Abstract: A method for producing a liquid reaction mixture containing a radioisotope, in particular, a radioactive composition, minimizes device contamination with radioactive substances and increase speed and accuracy with which droplets are mixed. The method for producing a radioactive composition includes placing at least one first droplet L1 containing a radionuclide and at least one second droplet L2 containing a labeling substance on at least two respective dimples 5 among dimples 5 on a front surface 4b of an insulating layer 4 of a liquid manipulation device 1, and obtaining a liquid mixture M by using a change in electrostatic force caused by changing voltage applied to the electrodes 3 to thereby cause a relative movement between the at least one first droplet L1 and the at least one second droplet L2 so that the at least one first droplet L1 and the at least one second droplet L2 are mixed together at any one dimple among the dimples 5.

    Method for producing radioactive composition
    6.
    发明授权
    Method for producing radioactive composition 有权

    公开(公告)号：US11548004B2

    公开(公告)日：2023-01-10

    申请号：US17317273

    申请日：2021-05-11

    Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY ,  KYOTO PHARMACEUTICAL UNIVERSITY

    Inventor： Katsuo Mogi ,  Tohru Natsume ,  Shungo Adachi ,  Tomoya Inoue ,  Hiroyuki Kimura

    IPC: B01L3/00

    Abstract: A method for producing a liquid reaction mixture containing a radioisotope, in particular, a radioactive composition, minimizes device contamination with radioactive substances and increase speed and accuracy with which droplets are mixed. The method for producing a radioactive composition includes placing at least one first droplet L1 containing a radionuclide and at least one second droplet L2 containing a labeling substance on at least two respective dimples 5 among dimples 5 on a front surface 4b of an insulating layer 4 of a liquid manipulation device 1, and obtaining a liquid mixture M by using a change in electrostatic force caused by changing voltage applied to the electrodes 3 to thereby cause a relative movement between the at least one first droplet L1 and the at least one second droplet L2 so that the at least one first droplet L1 and the at least one second droplet L2 are mixed together at any one dimple among the dimples 5.

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