公开(公告)号：US20150166578A1

公开(公告)日：2015-06-18

申请号：US14409882

申请日：2013-06-27

Applicant: NOVARTIS AG

Inventor： Eva Altmann ,  Ulrich Hommel ,  Edwige Liliane Jeanne Lorthiois ,  Jeurgen Klaus Maibaum ,  Nils Ostermann ,  Stefan Andreas Randl ,  Olivier Rogel ,  Anna Vulpetti

IPC: C07F7/08 ,  C07D403/12 ,  C07D403/14 ,  C07D403/06 ,  C07D471/04

CPC classification number: C07F7/0812 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D471/04

Abstract: The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention and its therapeutic uses as complement pathway modulators for the treatment of ocular diseases. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract translation: 本发明提供式（I）化合物，其是制备本发明化合物的方法及其作为治疗眼部疾病的补体途径调节剂的治疗用途。 本发明还提供药理活性剂和药物组合物的组合。

公开(公告)号：US20150190457A1

公开(公告)日：2015-07-09

申请号：US14409893

申请日：2013-06-27

Applicant: NOVARTIS AG

Inventor： Eva Altmann ,  Ulrich Hommel ,  Edwige Liliane Jeanne Lorthiois ,  Jeurgen Klaus Maibaum ,  Nils Ostermann ,  Jean Quancard ,  Stefan Andreas Randl ,  Olivier Rogel ,  Anna Vulpetti

IPC: A61K38/05 ,  C07D403/12 ,  C07K5/062

CPC classification number: A61K38/05 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D417/14 ,  C07D471/04 ,  C07K5/06026

Abstract: The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses as complement pathway modulators for the treatment of ocular diseases. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract translation: 本发明提供式（I）化合物，其制备本发明化合物的方法及其作为治疗眼部疾病的补体途径调节剂的治疗用途。 本发明还提供药理活性剂和药物组合物的组合。

公开(公告)号：US09815819B2

公开(公告)日：2017-11-14

申请号：US14409871

申请日：2013-06-27

Applicant: Novartis AG

Inventor： Eva Altmann ,  Ulrich Hommel ,  Edwige Liliane Jeanne Lorthiois ,  Jeurgen Klaus Maibaum ,  Nils Ostermann ,  Jean Quancard ,  Stefan Andreas Randl ,  Olivier Rogel ,  Anna Vulpetti

IPC: C07D471/04 ,  C07D491/056 ,  C07D403/06 ,  A61K31/416 ,  A61K31/4162 ,  A61K45/06

CPC classification number: C07D403/06 ,  A61K31/416 ,  A61K31/4162 ,  A61K45/06 ,  C07D471/04 ,  C07D491/056 ,  A61K2300/00

Abstract: The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US09487483B2

公开(公告)日：2016-11-08

申请号：US14409911

申请日：2013-06-27

Applicant: Novartis AG

Inventor： Eva Altmann ,  Ulrich Hommel ,  Edwige Liliane Jeanne Lorthiois ,  Jeurgen Klaus Maibaum ,  Nils Ostermann ,  Jean Quancard ,  Stefan Andreas Randl ,  Olivier Rogel ,  Anna Vulpetti ,  Stefanie Flohr

IPC: C07D209/52 ,  C07D471/04 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D487/04 ,  A61K45/06

CPC classification number: C07D209/52 ,  A61K45/06 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention provides a compound of formula (I): a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US09468661B2

公开(公告)日：2016-10-18

申请号：US14409893

申请日：2013-06-27

Applicant: NOVARTIS AG

Inventor： Eva Altmann ,  Ulrich Hommel ,  Edwige Liliane Jeanne Lorthiois ,  Jeurgen Klaus Maibaum ,  Nils Ostermann ,  Jean Quancard ,  Stefan Andreas Randl ,  Olivier Rogel ,  Anna Vulpetti

IPC: A61K38/05 ,  C07D403/12 ,  C07D403/06 ,  C07D403/14 ,  C07D417/14 ,  C07D471/04 ,  C07K5/062

CPC classification number: A61K38/05 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D417/14 ,  C07D471/04 ,  C07K5/06026

Abstract: The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses as complement pathway modulators for the treatment of ocular diseases. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US09388199B2

公开(公告)日：2016-07-12

申请号：US14409882

申请日：2013-06-27

Applicant: NOVARTIS AG

Inventor： Eva Altmann ,  Ulrich Hommel ,  Edwige Liliane Jeanne Lorthiois ,  Jeurgen Klaus Maibaum ,  Nils Ostermann ,  Stefan Andreas Randl ,  Olivier Rogel ,  Anna Vulpetti

IPC: C07D403/06 ,  C07D403/14 ,  C07D471/04 ,  C07D403/12 ,  C07F7/08

CPC classification number: C07F7/0812 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D471/04

Abstract: The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention and its therapeutic uses as complement pathway modulators for the treatment of ocular diseases. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract translation: 本发明提供式（I）化合物，其是制备本发明化合物的方法及其治疗用途，用作治疗眼部疾病的补体途径调节剂。 本发明还提供药理活性剂和药物组合物的组合。