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公开(公告)号：US09464081B2
公开(公告)日：2016-10-11
申请号：US14409878
申请日：2013-06-27
Applicant: Novartis AG
Inventor： Stefanie Flohr , Ulrich Hommel , Edwige Liliane Jeanne Lorthiois , Jeurgen Klaus Maibaum , Nils Ostermann , Jean Quancard , Stefan Andreas Randl , Olivier Rogel , Anna Vulpetti
IPC: C07D471/04 , C07D403/14 , C07D403/06 , C07D403/12
CPC classification number: C07D471/04 , C07D403/06 , C07D403/12 , C07D403/14
Abstract: The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses as a factor D inhibitor for the treatment of ophthalmic diseases. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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2.发明申请公开(公告)号：US20150166578A1
公开(公告)日：2015-06-18
申请号：US14409882
申请日：2013-06-27
Applicant: NOVARTIS AG
Inventor： Eva Altmann , Ulrich Hommel , Edwige Liliane Jeanne Lorthiois , Jeurgen Klaus Maibaum , Nils Ostermann , Stefan Andreas Randl , Olivier Rogel , Anna Vulpetti
IPC: C07F7/08 , C07D403/12 , C07D403/14 , C07D403/06 , C07D471/04
CPC classification number: C07F7/0812 , C07D403/06 , C07D403/12 , C07D403/14 , C07D471/04
Abstract: The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention and its therapeutic uses as complement pathway modulators for the treatment of ocular diseases. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Abstract translation: 本发明提供式（I）化合物，其是制备本发明化合物的方法及其作为治疗眼部疾病的补体途径调节剂的治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US20150148374A1
公开(公告)日：2015-05-28
申请号：US14409914
申请日：2013-06-27
Applicant: NOVARTIS AG
Inventor： Ulrich Hommel , Edwige Liliane Jeanne Lorthiois , Jeurgen Klaus Maibaum , Nils Ostermann , Stefan Andreas Randl , Olivier Rogel , Anna Vulpetti
IPC: C07D403/14 , C07D471/04
CPC classification number: C07D403/14 , A61K31/4155 , A61K31/416 , A61K31/437 , A61K45/06 , C07D471/04 , A61K2300/00
Abstract: The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Abstract translation: 本发明提供式I化合物：制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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4.发明申请公开(公告)号：US20150190457A1
公开(公告)日：2015-07-09
申请号：US14409893
申请日：2013-06-27
Applicant: NOVARTIS AG
Inventor： Eva Altmann , Ulrich Hommel , Edwige Liliane Jeanne Lorthiois , Jeurgen Klaus Maibaum , Nils Ostermann , Jean Quancard , Stefan Andreas Randl , Olivier Rogel , Anna Vulpetti
IPC: A61K38/05 , C07D403/12 , C07K5/062
CPC classification number: A61K38/05 , C07D403/06 , C07D403/12 , C07D403/14 , C07D417/14 , C07D471/04 , C07K5/06026
Abstract: The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses as complement pathway modulators for the treatment of ocular diseases. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Abstract translation: 本发明提供式（I）化合物，其制备本发明化合物的方法及其作为治疗眼部疾病的补体途径调节剂的治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US09815819B2
公开(公告)日：2017-11-14
申请号：US14409871
申请日：2013-06-27
Applicant: Novartis AG
Inventor： Eva Altmann , Ulrich Hommel , Edwige Liliane Jeanne Lorthiois , Jeurgen Klaus Maibaum , Nils Ostermann , Jean Quancard , Stefan Andreas Randl , Olivier Rogel , Anna Vulpetti
IPC: C07D471/04 , C07D491/056 , C07D403/06 , A61K31/416 , A61K31/4162 , A61K45/06
CPC classification number: C07D403/06 , A61K31/416 , A61K31/4162 , A61K45/06 , C07D471/04 , C07D491/056 , A61K2300/00
Abstract: The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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Patent Agency Ranking
公开(公告)号：US09550755B2
公开(公告)日：2017-01-24
申请号：US14409914
申请日：2013-06-27
Applicant: NOVARTIS AG
Inventor： Ulrich Hommel , Edwige Liliane Jeanne Lorthiois , Jeurgen Klaus Maibaum , Nils Ostermann , Stefan Andreas Randl , Olivier Rogel , Anna Vulpetti
IPC: A61K31/44 , C07D471/02 , C07D403/14 , A61K45/06 , A61K31/4155 , A61K31/416 , A61K31/437 , C07D471/04
CPC classification number: C07D403/14 , A61K31/4155 , A61K31/416 , A61K31/437 , A61K45/06 , C07D471/04 , A61K2300/00
Abstract: The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Abstract translation: 本发明提供式I化合物：制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US09487483B2
公开(公告)日：2016-11-08
申请号：US14409911
申请日：2013-06-27
Applicant: Novartis AG
Inventor： Eva Altmann , Ulrich Hommel , Edwige Liliane Jeanne Lorthiois , Jeurgen Klaus Maibaum , Nils Ostermann , Jean Quancard , Stefan Andreas Randl , Olivier Rogel , Anna Vulpetti , Stefanie Flohr
IPC: C07D209/52 , C07D471/04 , C07D401/14 , C07D403/06 , C07D403/14 , C07D487/04 , A61K45/06
CPC classification number: C07D209/52 , A61K45/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D471/04 , C07D487/04
Abstract: The present invention provides a compound of formula (I): a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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8.发明授权公开(公告)号：US09468661B2
公开(公告)日：2016-10-18
申请号：US14409893
申请日：2013-06-27
Applicant: NOVARTIS AG
Inventor： Eva Altmann , Ulrich Hommel , Edwige Liliane Jeanne Lorthiois , Jeurgen Klaus Maibaum , Nils Ostermann , Jean Quancard , Stefan Andreas Randl , Olivier Rogel , Anna Vulpetti
IPC: A61K38/05 , C07D403/12 , C07D403/06 , C07D403/14 , C07D417/14 , C07D471/04 , C07K5/062
CPC classification number: A61K38/05 , C07D403/06 , C07D403/12 , C07D403/14 , C07D417/14 , C07D471/04 , C07K5/06026
Abstract: The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses as complement pathway modulators for the treatment of ocular diseases. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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9.发明授权公开(公告)号：US09388199B2
公开(公告)日：2016-07-12
申请号：US14409882
申请日：2013-06-27
Applicant: NOVARTIS AG
Inventor： Eva Altmann , Ulrich Hommel , Edwige Liliane Jeanne Lorthiois , Jeurgen Klaus Maibaum , Nils Ostermann , Stefan Andreas Randl , Olivier Rogel , Anna Vulpetti
IPC: C07D403/06 , C07D403/14 , C07D471/04 , C07D403/12 , C07F7/08
CPC classification number: C07F7/0812 , C07D403/06 , C07D403/12 , C07D403/14 , C07D471/04
Abstract: The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention and its therapeutic uses as complement pathway modulators for the treatment of ocular diseases. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Abstract translation: 本发明提供式（I）化合物，其是制备本发明化合物的方法及其治疗用途，用作治疗眼部疾病的补体途径调节剂。 本发明还提供药理活性剂和药物组合物的组合。
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10.发明申请公开(公告)号：US20150191462A1
公开(公告)日：2015-07-09
申请号：US14409903
申请日：2013-06-27
Applicant: NOVARTIS AG
Inventor： Ulrich Hommel , Edwige Liliane Jeanne Lorthiois , Jeurgen Klaus Maibaum , Nils Ostermann , Stefan Andreas Randl , Olivier Rogel , Anna Vulpetti
IPC: C07D471/04 , C07D401/14 , C07D403/14 , C07D417/14
CPC classification number: C07D471/04 , C07D401/14 , C07D403/14 , C07D417/14
Abstract: The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses as complement alternative inhibitors for the treatment of ocular diseases. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Abstract translation: 本发明提供式I化合物：（I）制备本发明化合物的方法及其作为治疗眼部疾病的补体替代抑制剂的治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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