公开(公告)号：US09815819B2

公开(公告)日：2017-11-14

申请号：US14409871

申请日：2013-06-27

Applicant: Novartis AG

Inventor： Eva Altmann ,  Ulrich Hommel ,  Edwige Liliane Jeanne Lorthiois ,  Jeurgen Klaus Maibaum ,  Nils Ostermann ,  Jean Quancard ,  Stefan Andreas Randl ,  Olivier Rogel ,  Anna Vulpetti

IPC: C07D471/04 ,  C07D491/056 ,  C07D403/06 ,  A61K31/416 ,  A61K31/4162 ,  A61K45/06

CPC classification number: C07D403/06 ,  A61K31/416 ,  A61K31/4162 ,  A61K45/06 ,  C07D471/04 ,  C07D491/056 ,  A61K2300/00

Abstract: The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US09487483B2

公开(公告)日：2016-11-08

申请号：US14409911

申请日：2013-06-27

Applicant: Novartis AG

Inventor： Eva Altmann ,  Ulrich Hommel ,  Edwige Liliane Jeanne Lorthiois ,  Jeurgen Klaus Maibaum ,  Nils Ostermann ,  Jean Quancard ,  Stefan Andreas Randl ,  Olivier Rogel ,  Anna Vulpetti ,  Stefanie Flohr

IPC: C07D209/52 ,  C07D471/04 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D487/04 ,  A61K45/06

CPC classification number: C07D209/52 ,  A61K45/06 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention provides a compound of formula (I): a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US09468661B2

公开(公告)日：2016-10-18

申请号：US14409893

申请日：2013-06-27

Applicant: NOVARTIS AG

Inventor： Eva Altmann ,  Ulrich Hommel ,  Edwige Liliane Jeanne Lorthiois ,  Jeurgen Klaus Maibaum ,  Nils Ostermann ,  Jean Quancard ,  Stefan Andreas Randl ,  Olivier Rogel ,  Anna Vulpetti

IPC: A61K38/05 ,  C07D403/12 ,  C07D403/06 ,  C07D403/14 ,  C07D417/14 ,  C07D471/04 ,  C07K5/062

CPC classification number: A61K38/05 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D417/14 ,  C07D471/04 ,  C07K5/06026

Abstract: The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses as complement pathway modulators for the treatment of ocular diseases. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20180030061A1

公开(公告)日：2018-02-01

申请号：US15729979

申请日：2017-10-11

Applicant: NOVARTIS AG

Inventor： Carole Pissot Soldermann ,  Jean Quancard ,  Achim Schlapbach ,  Oliver Simic ,  Marina Tintelnot-Blomley ,  Thomas Zoller

IPC: C07D487/04 ,  A61K31/5377 ,  A61K31/519

Abstract: The present invention describes new pyrazolo-pyrimidine derivatives which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.

公开(公告)号：US09464081B2

公开(公告)日：2016-10-11

申请号：US14409878

申请日：2013-06-27

Applicant: Novartis AG

Inventor： Stefanie Flohr ,  Ulrich Hommel ,  Edwige Liliane Jeanne Lorthiois ,  Jeurgen Klaus Maibaum ,  Nils Ostermann ,  Jean Quancard ,  Stefan Andreas Randl ,  Olivier Rogel ,  Anna Vulpetti

IPC: C07D471/04 ,  C07D403/14 ,  C07D403/06 ,  C07D403/12

CPC classification number: C07D471/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14

Abstract: The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses as a factor D inhibitor for the treatment of ophthalmic diseases. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US10442808B2

公开(公告)日：2019-10-15

申请号：US15729979

申请日：2017-10-11

Applicant: NOVARTIS AG

Inventor： Carole Pissot Soldermann ,  Jean Quancard ,  Achim Schlapbach ,  Oliver Simic ,  Marina Tintelnot-Blomley ,  Thomas Zoller

IPC: A61K31/519 ,  A61K31/5377 ,  C07D487/04

Abstract: The present invention describes new pyrazolo-pyrimidine derivatives according to Formula (I) which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.

公开(公告)号：US20150190457A1

公开(公告)日：2015-07-09

申请号：US14409893

申请日：2013-06-27

Applicant: NOVARTIS AG

Inventor： Eva Altmann ,  Ulrich Hommel ,  Edwige Liliane Jeanne Lorthiois ,  Jeurgen Klaus Maibaum ,  Nils Ostermann ,  Jean Quancard ,  Stefan Andreas Randl ,  Olivier Rogel ,  Anna Vulpetti

IPC: A61K38/05 ,  C07D403/12 ,  C07K5/062

CPC classification number: A61K38/05 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D417/14 ,  C07D471/04 ,  C07K5/06026

Abstract: The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses as complement pathway modulators for the treatment of ocular diseases. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract translation: 本发明提供式（I）化合物，其制备本发明化合物的方法及其作为治疗眼部疾病的补体途径调节剂的治疗用途。 本发明还提供药理活性剂和药物组合物的组合。