公开(公告)号：US12280041B2

公开(公告)日：2025-04-22

申请号：US18048016

申请日：2022-10-19

Applicant: NOVARTIS AG

Inventor： Ha-Soon Choi ,  James Paul Lajiness ,  Srinivasa Reddy Natala ,  Bao Nguyen ,  Hank Michael James Petrassi ,  Zhicheng Wang

IPC: A61K31/443 ,  A61K31/34 ,  A61K31/351 ,  A61K31/4155 ,  A61K31/416 ,  A61K31/4245 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4525 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  A61L27/54 ,  C07D491/18 ,  C07D493/08 ,  C12N5/077

Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds, and methods of using such compounds for treatment of joint damage or joint injury in a mammal, and for inducing differentiation of mesenchymal stem cells into chondrocytes.

公开(公告)号：US11203595B2

公开(公告)日：2021-12-21

申请号：US16941395

申请日：2020-07-28

Applicant: NOVARTIS AG

Inventor： Badry Bursulaya ,  Andreas Fisch ,  James Paul Lajiness ,  Rainer Machauer ,  Swapnil Malekar ,  Hank Michael James Petrassi ,  Farshad Ramazani ,  Anne-Catherine Remond ,  Thomas Ullrich ,  Peggy Usselmann ,  Eric Vangrevelinghe

IPC: C07D471/04 ,  A61K9/19 ,  A61P21/00 ,  A61K9/00 ,  A61K9/50 ,  A61K31/437 ,  A61K31/496 ,  A61K31/538

Abstract: The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US11753416B2

公开(公告)日：2023-09-12

申请号：US17368537

申请日：2021-07-06

Applicant: NOVARTIS AG

Inventor： Ha-Soon Choi ,  Jiqing Jiang ,  James Paul Lajiness ,  Bao Nguyen ,  Hank Michael James Petrassi

IPC: C07D493/08 ,  A61K9/00 ,  A61K31/343

CPC classification number: C07D493/08 ,  A61K9/0053 ,  A61K31/343

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof;






or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating joint damage or injury in a mammal, for inducing hyaline cartilage production or for inducing differentiation of chondrogenic progenitor cells into mature chondrocytes.

公开(公告)号：US11510912B2

公开(公告)日：2022-11-29

申请号：US16848568

申请日：2020-04-14

Applicant: NOVARTIS AG

Inventor： Ha-Soon Choi ,  James Paul Lajiness ,  Srinivasa Reddy Natala ,  Bao Nguyen ,  Hank Michael James Petrassi ,  Zhicheng Wang

IPC: A61K31/443 ,  A61K31/4245 ,  A61K31/4155 ,  A61K31/506 ,  A61K31/34 ,  A61K31/4439 ,  A61K31/5377 ,  A61K31/351 ,  A61K31/4545 ,  A61K31/4525 ,  A61K31/497 ,  A61K31/444 ,  A61K45/06 ,  C07D491/18 ,  C07D493/08 ,  A61K31/416 ,  A61K31/4433 ,  A61L27/54 ,  C12N5/077

Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds, and methods of using such compounds for treatment of joint damage or joint injury in a mammal, and for inducing differentiation of mesenchymal stem cells into chondrocytes.

公开(公告)号：US10188638B2

公开(公告)日：2019-01-29

申请号：US15587652

申请日：2017-05-05

Applicant: NOVARTIS AG

Inventor： Ha-Soon Choi ,  James Paul Lajiness ,  Srinivasa Reddy Natala ,  Bao Nguyen ,  Hank Michael James Petrassi ,  Zhicheng Wang

IPC: A61K31/443 ,  C07D493/08 ,  A61K31/4245 ,  A61K31/4155 ,  A61K31/506 ,  A61K31/34 ,  A61K31/4439 ,  A61K31/5377 ,  A61K31/351 ,  A61K31/4545 ,  A61K31/4525 ,  A61K31/497 ,  A61K31/444 ,  A61K45/06 ,  C07D491/18 ,  A61K31/416 ,  A61K31/4433 ,  A61L27/54 ,  C12N5/077

Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds, and methods of using such compounds for treatment of joint damage or joint injury in a mammal, and for inducing differentiation of mesenchymal stem cells into chondrocytes.

公开(公告)号：US10112907B2

公开(公告)日：2018-10-30

申请号：US15711984

申请日：2017-09-21

Applicant: NOVARTIS AG

Inventor： Badry Bursulaya ,  Andreas Fisch ,  James Paul Lajiness ,  Rainer Machauer ,  Swapnil Malekar ,  Hank Michael James Petrassi ,  Farshad Ramazani ,  Anne-Catherine Remond ,  Thomas Ullrich ,  Peggy Usselmann ,  Eric Vangrevelinghe

IPC: A61K31/416 ,  C07D231/56 ,  A61K9/00 ,  A61K9/16 ,  A61K31/454 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12

Abstract: The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20210079010A1

公开(公告)日：2021-03-18

申请号：US16620407

申请日：2018-06-07

Applicant: NOVARTIS AG

Inventor： Ha-Soon CHOI ,  Jiqing JIANG ,  James Paul LAJINESS ,  Bao NGUYEN ,  Hank Michael James Petrassi

IPC: C07D493/08 ,  A61K31/343 ,  A61K9/00

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; (I) or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating joint damage or injury in a mammal, for inducing hyaline cartilage production or for inducing differentiation of chondrogenic progenitor cells into mature chondrocytes.

公开(公告)号：US20190314348A1

公开(公告)日：2019-10-17

申请号：US16448547

申请日：2019-06-21

Applicant: NOVARTIS AG

Inventor： Ha-Soon Choi ,  James Paul Lajiness ,  Srinivasa Reddy Natala ,  Bao Nguyen ,  Hank Michael James Petrassi ,  Zhicheng Wang

IPC: A61K31/443 ,  A61K45/06 ,  C07D491/18 ,  A61K31/497 ,  A61K31/4525 ,  A61K31/4545 ,  A61K31/351 ,  A61K31/5377 ,  A61K31/4439 ,  A61K31/34 ,  A61K31/506 ,  A61K31/4155 ,  A61K31/4245 ,  A61K31/444 ,  C07D493/08 ,  A61K31/4433 ,  A61K31/416 ,  A61L27/54 ,  C12N5/077

Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds, and methods of using such compounds for treatment of joint damage or joint injury in a mammal, and for inducing differentiation of mesenchymal stem cells into chondrocytes.

公开(公告)号：US20170239227A1

公开(公告)日：2017-08-24

申请号：US15587652

申请日：2017-05-05

Applicant: NOVARTIS AG

Inventor： Ha-Soon Choi ,  James Paul Lajiness ,  Srinivasa Reddy Natala ,  Bao Nguyen ,  Hank Michael James Petrassi ,  Zhicheng Wang

IPC: A61K31/443 ,  A61K31/4155 ,  A61K31/506 ,  A61K31/34 ,  A61K31/4439 ,  A61K31/5377 ,  A61K31/416 ,  A61K31/351 ,  A61K31/4545 ,  A61K31/4525 ,  A61K31/497 ,  A61K31/4433 ,  A61K31/444 ,  C12N5/077 ,  A61K45/06 ,  A61L27/54 ,  A61K31/4245

CPC classification number: A61K31/443 ,  A61K31/34 ,  A61K31/351 ,  A61K31/4155 ,  A61K31/416 ,  A61K31/4245 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4525 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  A61L27/54 ,  A61L2300/412 ,  A61L2430/06 ,  C07D491/18 ,  C07D493/08 ,  C12N5/0655 ,  C12N2501/999 ,  C12N2506/1346

Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds, and methods of using such compounds for treatment of joint damage or joint injury in a mammal, and for inducing differentiation of mesenchymal stem cells into chondrocytes.

公开(公告)号：US12209096B2

公开(公告)日：2025-01-28

申请号：US18354163

申请日：2023-07-18

Applicant: NOVARTIS AG

Inventor： Ha-Soon Choi ,  Jiqing Jiang ,  James Paul Lajiness ,  Bao Nguyen ,  Hank Michael James Petrassi

IPC: C07D493/08 ,  A61K9/00 ,  A61K31/343

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating joint damage or injury in a mammal, for inducing hyaline cartilage production or for inducing differentiation of chondrogenic progenitor cells into mature chondrocytes.