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    Phytase variants
    3.
    发明授权
    Phytase variants 有权

    公开(公告)号：US10041052B2

    公开(公告)日：2018-08-07

    申请号：US15249856

    申请日：2016-08-29

    Applicant: Novozymes A/S

    Inventor： Leonardo De Maria ,  Carsten Andersen ,  Lars Kobberoee Skov ,  Mikael Blom Soerensen

    IPC: C12N9/16 ,  A23K20/189

    Abstract: The present invention relates to a phytase which has at least 74% identity to a phytase derived from Citrobacter braakii and comprises at least one alteration as compared to this phytase. These phytase variants have amended, preferably improved, properties, such as thermostability, temperature profile, pH profile, specific activity, performance in animal feed, reduced protease sensibility, and/or an amended glycosylation pattern. The invention also relates to DNA encoding these phytases, methods of their production, as well as the use thereof, e.g., in animal feed and animal feed additives.

    Polypeptides having phytase activity and polynucleotides encoding same
    4.
    发明授权
    Polypeptides having phytase activity and polynucleotides encoding same 有权

    公开(公告)号：US09365840B2

    公开(公告)日：2016-06-14

    申请号：US14051945

    申请日：2013-10-11

    Applicant: Novozymes A/S

    Inventor： Carsten Sjoeholm ,  Soeren Flensted Lassen ,  Lars Kobberoee Skov ,  Leonardo De Maria

    IPC: C12N9/16 ,  C12P7/06 ,  C07K14/195 ,  A61K38/16 ,  C12N15/82 ,  A23L1/305

    CPC classification number: C12N9/16 ,  A23L33/18 ,  C12N15/8243 ,  C12P7/06 ,  Y02E50/17

    Abstract: The present invention relates to polypeptides having phytase activity. These polypeptides have an amino acid sequence which has at least 70% identity to either of three phytases derived from the bacterium Buttiauxella, and which comprises at least one of the following amino acids at the position indicated: 119N, 120L, and/or 121E. These phytases have an improved specific activity. Additional specific amino acid substitutions are also disclosed which characterize and distinguish additional phytases of the invention having improved properties such as temperature and/or pH stability, pH activity profile, temperature activity profile, substrate profile, improved performance in animal feed in vitro or in vivo. The invention also relates to isolated polynucleotides encoding the polypeptides, nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.

    Phytase Variants
    7.
    发明申请
    Phytase Variants 审中-公开
    植酸酶变体

    公开(公告)号：US20150024084A1

    公开(公告)日：2015-01-22

    申请号：US14504517

    申请日：2014-10-02

    Applicant: NOVOZYMES A/S

    Inventor： Leonardo De Maria ,  Carsten Andersen ,  Lars Kobberoee Skov ,  Mikael Blom Soerensen

    IPC: A23K1/165 ,  C12N9/16

    CPC classification number: C12N9/16 ,  A23K20/189 ,  C12Y301/03

    Abstract: The present invention relates to a phytase which has at least 74% identity to a phytase derived from Citrobacter braakii and comprises at least one alteration as compared to this phytase. These phytase variants have amended, preferably improved, properties, such as thermostability, temperature profile, pH profile, specific activity, performance in animal feed, reduced protease sensitiliby, and/or an amended glycosylation pattern. The invention also relates to DNA encoding these phytases, methods of their production, as well as the use thereof, e.g., in animal feed and animal feed additives.

    Abstract translation: 本发明涉及一种植酸酶，其与来自柠檬酸杆菌的植酸酶具有至少74％的同一性，并且与该植酸酶相比包含至少一个改变。 这些植酸酶变体具有修饰，优选改进的性质，例如热稳定性，温度曲线，pH曲线，比活性，动物饲料中的性能，降低的蛋白酶敏感性和/或修饰的糖基化模式。 本发明还涉及编码这些植酸酶的DNA，其生产方法及其用途，例如在动物饲料和动物饲料添加剂中。

    Phytase Variants
    9.
    发明申请
    Phytase Variants 有权
    植酸酶变体

    公开(公告)号：US20130224332A1

    公开(公告)日：2013-08-29

    申请号：US13874954

    申请日：2013-05-01

    Applicant: Novozymes A/S

    Inventor： Leonardo De Maria ,  Carsten Andersen ,  Lars Kobberoee Skov ,  Mikael Blom Soerensen

    IPC: C12N9/16 ,  A23K1/165

    CPC classification number: C12N9/16 ,  A23K20/189 ,  C12Y301/03

    Abstract: The present invention relates to a phytase which has at least 74% identity to a phytase derived from Citrobacter braakii and comprises at least one alteration as compared to this phytase. These phytase variants have amended, preferably improved, properties, such as thermostability, temperature profile, pH profile, specific activity, performance in animal feed, reduced protease sensitiliby, and/or an amended glycosylation pattern. The invention also relates to DNA encoding these phytases, methods of their production, as well as the use thereof, e.g. in animal feed and animal feed additives.

    Abstract translation: 本发明涉及一种植酸酶，其与来自柠檬酸杆菌的植酸酶具有至少74％的同一性，并且与该植酸酶相比包含至少一个改变。 这些植酸酶变体具有修饰，优选改进的性质，例如热稳定性，温度曲线，pH曲线，比活性，动物饲料中的性能，降低的蛋白酶敏感性和/或修饰的糖基化模式。 本发明还涉及编码这些植酸酶的DNA，其生产方法及其用途，例如， 在动物饲料和动物饲料添加剂中。

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