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    Phytase variants
    3.
    发明授权
    Phytase variants 有权

    公开(公告)号：US10041052B2

    公开(公告)日：2018-08-07

    申请号：US15249856

    申请日：2016-08-29

    申请人： Novozymes A/S

    发明人： Leonardo De Maria ,  Carsten Andersen ,  Lars Kobberoee Skov ,  Mikael Blom Soerensen

    IPC分类号： C12N9/16 ,  A23K20/189

    摘要： The present invention relates to a phytase which has at least 74% identity to a phytase derived from Citrobacter braakii and comprises at least one alteration as compared to this phytase. These phytase variants have amended, preferably improved, properties, such as thermostability, temperature profile, pH profile, specific activity, performance in animal feed, reduced protease sensibility, and/or an amended glycosylation pattern. The invention also relates to DNA encoding these phytases, methods of their production, as well as the use thereof, e.g., in animal feed and animal feed additives.

    Polypeptides having phytase activity and polynucleotides encoding same
    7.
    发明授权
    Polypeptides having phytase activity and polynucleotides encoding same 有权

    公开(公告)号：US09365840B2

    公开(公告)日：2016-06-14

    申请号：US14051945

    申请日：2013-10-11

    申请人： Novozymes A/S

    发明人： Carsten Sjoeholm ,  Soeren Flensted Lassen ,  Lars Kobberoee Skov ,  Leonardo De Maria

    IPC分类号： C12N9/16 ,  C12P7/06 ,  C07K14/195 ,  A61K38/16 ,  C12N15/82 ,  A23L1/305

    CPC分类号： C12N9/16 ,  A23L33/18 ,  C12N15/8243 ,  C12P7/06 ,  Y02E50/17

    摘要： The present invention relates to polypeptides having phytase activity. These polypeptides have an amino acid sequence which has at least 70% identity to either of three phytases derived from the bacterium Buttiauxella, and which comprises at least one of the following amino acids at the position indicated: 119N, 120L, and/or 121E. These phytases have an improved specific activity. Additional specific amino acid substitutions are also disclosed which characterize and distinguish additional phytases of the invention having improved properties such as temperature and/or pH stability, pH activity profile, temperature activity profile, substrate profile, improved performance in animal feed in vitro or in vivo. The invention also relates to isolated polynucleotides encoding the polypeptides, nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.