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1.发明授权Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof 失效阿仑膦酸钠的水合物形式，其制备方法及其药物组合物公开(公告)号：US06281381B1
公开(公告)日：2001-08-28
申请号：US09384145
申请日：1999-08-27
IPC分类号： C07F938
CPC分类号： C07F9/3873
摘要： New hydrate forms of alendronate sodium, having water content of between about one and about twelve percent, and processes for their manufacture, are disclosed. New crystalline forms of alendronate sodium B, D, E, F, G and H, and processes for manufacturing them, are also disclosed. These new forms of alendronate sodium are suitable for incorporation into pharmaceutical compositions for combating bone resorption in bone diseases.
摘要翻译： 公开了水含量为约1至约12％的阿仑膦酸钠的新水合物形式及其制备方法。 还公开了阿仑膦酸钠B，D，E，F，G和H的新结晶形式及其制备方法。 这些新形式的阿仑膦酸钠适于掺入用于对抗骨疾病中的骨吸收的药物组合物中。
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2.发明授权Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof 失效阿仑膦酸钠的水合物形式，其制备方法及其药物组合物公开(公告)号：US06963008B2
公开(公告)日：2005-11-08
申请号：US10751237
申请日：2003-12-31
CPC分类号： C07F9/3873
摘要： New hydrate forms of alendronate sodium, having water content of between about one and about twelve percent, and processes for their manufacture, are disclosed. New crystalline forms of alendronate sodium B, D, E, F, G and H, and processes for manufacturing them, are also disclosed. These new forms of alendronate sodium are suitable for incorporation into pharmaceutical compositions for combating bone resorption in bone diseases.
摘要翻译： 公开了水含量为约1至约12％的阿仑膦酸钠的新水合物形式及其制备方法。 还公开了阿仑膦酸钠B，D，E，F，G和H的新结晶形式及其制备方法。 这些新形式的阿仑膦酸钠适于掺入用于对抗骨疾病中的骨吸收的药物组合物中。
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3.发明授权Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof 失效阿仑膦酸钠的水合物形式，其制备方法及其药物组合物公开(公告)号：US06696601B2
公开(公告)日：2004-02-24
申请号：US09898756
申请日：2001-07-03
IPC分类号： C07F900
CPC分类号： C07F9/3873
摘要： New hydrate forms of alendronate sodium, having water content of between about one and about twelve percent, and processes for their manufacture, are disclosed. New crystalline forms of alendronate sodium B, D, E, F, G and H, and processes for manufacturing them, are also disclosed. These new forms of alendronate sodium are suitable for incorporation into pharmaceutical compositions for combating bone resorption in bone diseases.
摘要翻译： 公开了水含量为约1至约12％的阿仑膦酸钠的新水合物形式及其制备方法。 还公开了阿仑膦酸钠B，D，E，F，G和H的新结晶形式及其制备方法。 这些新形式的阿仑膦酸钠适于掺入用于对抗骨疾病中的骨吸收的药物组合物中。
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公开(公告)号：US20060100446A1
公开(公告)日：2006-05-11
申请号：US11257828
申请日：2005-10-24
申请人： Judith Aronhime , Ramy Lidor-Hadas , Valerie Niddam-Hildesheim , Revital Lifshitz-Liron , Shlomit Wizel
发明人： Judith Aronhime , Ramy Lidor-Hadas , Valerie Niddam-Hildesheim , Revital Lifshitz-Liron , Shlomit Wizel
IPC分类号： C07D207/24
CPC分类号： C07D207/34 , A61K9/282 , A61K9/5021 , C07D405/06
摘要： The present invention provides novel forms of atorvastatin designated Forms VI, VIII, IX, X, XI and XII and novel processes for their preparation as well as processes for preparing atorvastatin Forms I, II, IV, V and amorphous atorvastatin.
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公开(公告)号：US20060100267A1
公开(公告)日：2006-05-11
申请号：US11257886
申请日：2005-10-24
申请人： Judith Aronhime , Ramy Lidor-Hadas , Valerie Niddam-Hildesheim , Revital Lifshitz-Liron , Shlomit Wizel
发明人： Judith Aronhime , Ramy Lidor-Hadas , Valerie Niddam-Hildesheim , Revital Lifshitz-Liron , Shlomit Wizel
IPC分类号： A61K31/401 , C07D207/24
CPC分类号： C07D207/34 , A61K9/282 , A61K9/5021 , C07D405/06
摘要： The present invention provides novel forms of atorvastatin designated Forms VI, VIII, IX, X, XI and XII and novel processes for their preparation as well as processes for preparing atorvastatin Forms I, II, IV, V and amorphous atorvastatin.
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6.发明申请Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms 失效阿伐他汀半钙的新型晶体形式及其制备方法以及制备其它形式的新方法公开(公告)号：US20050090542A1
公开(公告)日：2005-04-28
申请号：US10994142
申请日：2004-11-19
IPC分类号： A61K9/28 , A61K9/50 , A61K31/40 , A61K31/401 , A61P3/06 , A61P9/00 , B01D9/02 , C07D207/34 , C07D405/06
CPC分类号： C07D207/34 , A61K9/282 , A61K9/5021 , C07D405/06
摘要： The present invention provides novel forms of atorvastatin designated Forms VI, VIII, IX, X, XI and XII and novel processes for their preparation as well as processes for preparing atorvastatin Forms I, II, IV, V and amorphous atorvastatin.
摘要翻译： 本发明提供命名为形式VI，VIII，IX，X，XI和XII的阿托伐他汀的新形式及其制备方法以及制备阿托伐他汀形式I，II，IV，V和无定形阿托伐他汀的方法。
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7.发明授权Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms 失效阿伐他汀半钙的晶体形式及其制备方法以及制备其他形式的新方法公开(公告)号：US07488750B2
公开(公告)日：2009-02-10
申请号：US11257828
申请日：2005-10-24
IPC分类号： C07D207/34 , A61K31/40
CPC分类号： C07D207/34 , A61K9/282 , A61K9/5021 , C07D405/06
摘要： The present invention provides novel forms of atorvastatin designated Forms VI, VIII, IX, X, XI and XII and novel processes for their preparation as well as processes for preparing atorvastatin Forms I, II, IV, V and amorphous atorvastatin.
摘要翻译： 本发明提供命名为形式VI，VIII，IX，X，XI和XII的阿托伐他汀的新形式及其制备方法以及制备阿托伐他汀形式I，II，IV，V和无定形阿托伐他汀的方法。
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公开(公告)号：US07468444B2
公开(公告)日：2008-12-23
申请号：US11257979
申请日：2005-10-24
IPC分类号： C07D207/34 , A61K31/40
CPC分类号： C07D207/34 , A61K9/282 , A61K9/5021 , C07D405/06
摘要： The present invention provides novel forms of atorvastatin designated Forms VI, VIII, IX, X, XI and XII and novel processes for their preparation as well as processes for preparing atorvastatin Forms I, II, IV, V and amorphous atorvastatin.
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9.发明申请Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel process for preparing other forms 审中-公开阿伐他汀半钙的新型晶体形式及其制备方法以及制备其他形式的新方法公开(公告)号：US20080214650A1
公开(公告)日：2008-09-04
申请号：US11977387
申请日：2007-10-23
IPC分类号： A61K31/401 , C07D207/34
CPC分类号： C07D207/34 , A61K9/282 , A61K9/5021 , C07D405/06
摘要： The present invention provides novel forms of atorvastatin designated Forms VI, VIII, IX, X, XI and XII and novel processes for their preparation as well as processes for preparing atorvastatin Forms I, II, IV, V and amorphous atorvastatin.
摘要翻译： 本发明提供命名为形式VI，VIII，IX，X，XI和XII的阿托伐他汀的新形式及其制备方法以及制备阿托伐他汀形式I，II，IV，V和无定形阿托伐他汀的方法。
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公开(公告)号：US06605636B2
公开(公告)日：2003-08-12
申请号：US09992746
申请日：2001-11-05
IPC分类号： A61K3140
CPC分类号： C07D405/06 , A61K31/40 , C07D207/34
摘要： The present invention provides a novel form of atorvastatin hemi-calcium designated Form VII and novel processes for its preparation whereby another crystalline form of atorvastatin hemi-calcium is suspended in ethanol, preferably absolute ethanol, and is converted to the new form, which is then isolated. The present invention further provides a method of reducing the plasma low density lipoprotein level in patients suffering from or susceptible to hypercholesterolemia and compositions and dosage forms for practicing the invention.
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